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Potential of Bacterial Cellulose in Reconstructive Surgery of Body Integumentary System: Preliminary Studies in Animals

The aim of the study is to present the preliminary results of the in vivo application of Komagataeibacter xylinum E25 bacterial cellulose (BC) as a replacement material for produced defects during operations. Three pigs (sus scrofa domestica) had the same defects in the ear cartilage (4 × 4 cm) and...

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Autores principales: Błażyńska-Spychalska, Agata, Kur, Martyna, Brzeski, Tomasz, Zając, Wacław, Pankiewicz, Teresa, Bielecki, Stanisław, Woliński, Jarosław, Jankau, Jerzy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10455510/
https://www.ncbi.nlm.nih.gov/pubmed/37623642
http://dx.doi.org/10.3390/jfb14080397
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author Błażyńska-Spychalska, Agata
Kur, Martyna
Brzeski, Tomasz
Zając, Wacław
Pankiewicz, Teresa
Bielecki, Stanisław
Woliński, Jarosław
Jankau, Jerzy
author_facet Błażyńska-Spychalska, Agata
Kur, Martyna
Brzeski, Tomasz
Zając, Wacław
Pankiewicz, Teresa
Bielecki, Stanisław
Woliński, Jarosław
Jankau, Jerzy
author_sort Błażyńska-Spychalska, Agata
collection PubMed
description The aim of the study is to present the preliminary results of the in vivo application of Komagataeibacter xylinum E25 bacterial cellulose (BC) as a replacement material for produced defects during operations. Three pigs (sus scrofa domestica) had the same defects in the ear cartilage (4 × 4 cm) and in the rectus abdominis muscle (6 × 10 cm) with BC membranes implanted into them. The time of observation of the condition of the animals was 3 months. Implantation sites did not show clinical signs of complications in the form of inflammation or necrosis. Histologically, a normal scar was produced as a result of the material healing into the host’s body. In one case, no residual implant material was found at the site of implantation, and the remodeled scar confirmed healing. No systemic inflammatory reaction was observed in any of the animals. The host organism’s reaction to the bacterial cellulose allows us to believe that it meets the expectations as a material that can be widely used in reconstructive surgery. Nevertheless, this requires further research on a larger group and also using other foreign bodies. The next step would be an experiment on a group consisting of people.
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spelling pubmed-104555102023-08-26 Potential of Bacterial Cellulose in Reconstructive Surgery of Body Integumentary System: Preliminary Studies in Animals Błażyńska-Spychalska, Agata Kur, Martyna Brzeski, Tomasz Zając, Wacław Pankiewicz, Teresa Bielecki, Stanisław Woliński, Jarosław Jankau, Jerzy J Funct Biomater Article The aim of the study is to present the preliminary results of the in vivo application of Komagataeibacter xylinum E25 bacterial cellulose (BC) as a replacement material for produced defects during operations. Three pigs (sus scrofa domestica) had the same defects in the ear cartilage (4 × 4 cm) and in the rectus abdominis muscle (6 × 10 cm) with BC membranes implanted into them. The time of observation of the condition of the animals was 3 months. Implantation sites did not show clinical signs of complications in the form of inflammation or necrosis. Histologically, a normal scar was produced as a result of the material healing into the host’s body. In one case, no residual implant material was found at the site of implantation, and the remodeled scar confirmed healing. No systemic inflammatory reaction was observed in any of the animals. The host organism’s reaction to the bacterial cellulose allows us to believe that it meets the expectations as a material that can be widely used in reconstructive surgery. Nevertheless, this requires further research on a larger group and also using other foreign bodies. The next step would be an experiment on a group consisting of people. MDPI 2023-07-26 /pmc/articles/PMC10455510/ /pubmed/37623642 http://dx.doi.org/10.3390/jfb14080397 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Błażyńska-Spychalska, Agata
Kur, Martyna
Brzeski, Tomasz
Zając, Wacław
Pankiewicz, Teresa
Bielecki, Stanisław
Woliński, Jarosław
Jankau, Jerzy
Potential of Bacterial Cellulose in Reconstructive Surgery of Body Integumentary System: Preliminary Studies in Animals
title Potential of Bacterial Cellulose in Reconstructive Surgery of Body Integumentary System: Preliminary Studies in Animals
title_full Potential of Bacterial Cellulose in Reconstructive Surgery of Body Integumentary System: Preliminary Studies in Animals
title_fullStr Potential of Bacterial Cellulose in Reconstructive Surgery of Body Integumentary System: Preliminary Studies in Animals
title_full_unstemmed Potential of Bacterial Cellulose in Reconstructive Surgery of Body Integumentary System: Preliminary Studies in Animals
title_short Potential of Bacterial Cellulose in Reconstructive Surgery of Body Integumentary System: Preliminary Studies in Animals
title_sort potential of bacterial cellulose in reconstructive surgery of body integumentary system: preliminary studies in animals
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10455510/
https://www.ncbi.nlm.nih.gov/pubmed/37623642
http://dx.doi.org/10.3390/jfb14080397
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