Targeting SARS-CoV-2 Non-Structural Proteins

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an enveloped respiratory β coronavirus that causes coronavirus disease (COVID-19), leading to a deadly pandemic that has claimed millions of lives worldwide. Like other coronaviruses, the SARS-CoV-2 genome also codes for non-structural...

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Detalles Bibliográficos
Autores principales: Tam, Donald, Lorenzo-Leal, Ana C., Hernández, Luis Ricardo, Bach, Horacio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10455537/
https://www.ncbi.nlm.nih.gov/pubmed/37629182
http://dx.doi.org/10.3390/ijms241613002
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author Tam, Donald
Lorenzo-Leal, Ana C.
Hernández, Luis Ricardo
Bach, Horacio
author_facet Tam, Donald
Lorenzo-Leal, Ana C.
Hernández, Luis Ricardo
Bach, Horacio
author_sort Tam, Donald
collection PubMed
description Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an enveloped respiratory β coronavirus that causes coronavirus disease (COVID-19), leading to a deadly pandemic that has claimed millions of lives worldwide. Like other coronaviruses, the SARS-CoV-2 genome also codes for non-structural proteins (NSPs). These NSPs are found within open reading frame 1a (ORF1a) and open reading frame 1ab (ORF1ab) of the SARS-CoV-2 genome and encode NSP1 to NSP11 and NSP12 to NSP16, respectively. This study aimed to collect the available literature regarding NSP inhibitors. In addition, we searched the natural product database looking for similar structures. The results showed that similar structures could be tested as potential inhibitors of the NSPs.
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spelling pubmed-104555372023-08-26 Targeting SARS-CoV-2 Non-Structural Proteins Tam, Donald Lorenzo-Leal, Ana C. Hernández, Luis Ricardo Bach, Horacio Int J Mol Sci Review Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an enveloped respiratory β coronavirus that causes coronavirus disease (COVID-19), leading to a deadly pandemic that has claimed millions of lives worldwide. Like other coronaviruses, the SARS-CoV-2 genome also codes for non-structural proteins (NSPs). These NSPs are found within open reading frame 1a (ORF1a) and open reading frame 1ab (ORF1ab) of the SARS-CoV-2 genome and encode NSP1 to NSP11 and NSP12 to NSP16, respectively. This study aimed to collect the available literature regarding NSP inhibitors. In addition, we searched the natural product database looking for similar structures. The results showed that similar structures could be tested as potential inhibitors of the NSPs. MDPI 2023-08-20 /pmc/articles/PMC10455537/ /pubmed/37629182 http://dx.doi.org/10.3390/ijms241613002 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Tam, Donald
Lorenzo-Leal, Ana C.
Hernández, Luis Ricardo
Bach, Horacio
Targeting SARS-CoV-2 Non-Structural Proteins
title Targeting SARS-CoV-2 Non-Structural Proteins
title_full Targeting SARS-CoV-2 Non-Structural Proteins
title_fullStr Targeting SARS-CoV-2 Non-Structural Proteins
title_full_unstemmed Targeting SARS-CoV-2 Non-Structural Proteins
title_short Targeting SARS-CoV-2 Non-Structural Proteins
title_sort targeting sars-cov-2 non-structural proteins
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10455537/
https://www.ncbi.nlm.nih.gov/pubmed/37629182
http://dx.doi.org/10.3390/ijms241613002
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AT lorenzolealanac targetingsarscov2nonstructuralproteins
AT hernandezluisricardo targetingsarscov2nonstructuralproteins
AT bachhoracio targetingsarscov2nonstructuralproteins

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