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Novel Lactone-Based Insecticides and Drosophila suzukii Management: Synthesis, Potential Action Mechanisms and Selectivity for Non-Target Parasitoids

SIMPLE SUMMARY: Drosophila suzukii is an insect of global economic importance, including in the Neotropical region. Due to the difficulty in controlling this insect pest with conventional insecticidal molecules, it is necessary to search for novel alternatives. Here, we present the potential of synt...

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Autores principales: Mantilla Afanador, Javier G., Araujo, Sabrina H. C., Teixeira, Milena G., Lopes, Dayane T., Cerceau, Cristiane I., Andreazza, Felipe, Oliveira, Daiana C., Bernardi, Daniel, Moura, Wellington S., Aguiar, Raimundo W. S., Oliveira, Ana C. S. S., Santos, Gil R., Alvarenga, Elson S., Oliveira, Eugenio E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10455539/
https://www.ncbi.nlm.nih.gov/pubmed/37623407
http://dx.doi.org/10.3390/insects14080697
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author Mantilla Afanador, Javier G.
Araujo, Sabrina H. C.
Teixeira, Milena G.
Lopes, Dayane T.
Cerceau, Cristiane I.
Andreazza, Felipe
Oliveira, Daiana C.
Bernardi, Daniel
Moura, Wellington S.
Aguiar, Raimundo W. S.
Oliveira, Ana C. S. S.
Santos, Gil R.
Alvarenga, Elson S.
Oliveira, Eugenio E.
author_facet Mantilla Afanador, Javier G.
Araujo, Sabrina H. C.
Teixeira, Milena G.
Lopes, Dayane T.
Cerceau, Cristiane I.
Andreazza, Felipe
Oliveira, Daiana C.
Bernardi, Daniel
Moura, Wellington S.
Aguiar, Raimundo W. S.
Oliveira, Ana C. S. S.
Santos, Gil R.
Alvarenga, Elson S.
Oliveira, Eugenio E.
author_sort Mantilla Afanador, Javier G.
collection PubMed
description SIMPLE SUMMARY: Drosophila suzukii is an insect of global economic importance, including in the Neotropical region. Due to the difficulty in controlling this insect pest with conventional insecticidal molecules, it is necessary to search for novel alternatives. Here, we present the potential of synthetic lactone-based insecticides to control D. suzukii. Additionally, we demonstrate molecular predictions regarding the actions of these molecules on the nervous system of the target pest and on the nervous system of its parasitoid, Trichopria anastrephae. By using in silico approaches, we demonstrate that the lactone derivatives (rac)-8 and compound 4 predominantly affect the TRP channels of D. suzukii (TRPM) and exhibit less stable interactions with the TRP channels expressed in T. anastrephae. ABSTRACT: Drosophila suzukii, an invasive insect pest, poses a significant threat to various fruit crops. The use of broad-spectrum insecticides to control this pest can reduce the effectiveness of biological control agents, such as the parasitoid Trichopria anastrephae. Here, we evaluated the toxicity of newly synthesized lactone derivatives on D. suzukii and their selectivity towards T. anastrephae. We used in silico approaches to identify potential targets from the most promising molecules in the D. suzukii nervous system and to understand potential differences in susceptibilities between D. suzukii and its parasitoid. Of the nine molecules tested, (rac)-8 and compound 4 demonstrated efficacy against the fly. Exposure to the estimated LC(90) of (rac)-8 and compound 4 resulted in a mortality rate of less than 20% for T. anastrephae without impairing the parasitoid’s functional parasitism. The in silico predictions suggest that (rac)-8 and compound 4 target gamma amino butyric acid (GABA) receptors and transient receptor potential (TRP) channels of D. suzukii. However, only the reduced interaction with TRP channels in T. anastrephae demonstrated a potential reason for the selectivity of these compounds on the parasitoid. Our findings suggest the potential for integrating (rac)-8 and compound 4 into D. suzukii management practices.
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spelling pubmed-104555392023-08-26 Novel Lactone-Based Insecticides and Drosophila suzukii Management: Synthesis, Potential Action Mechanisms and Selectivity for Non-Target Parasitoids Mantilla Afanador, Javier G. Araujo, Sabrina H. C. Teixeira, Milena G. Lopes, Dayane T. Cerceau, Cristiane I. Andreazza, Felipe Oliveira, Daiana C. Bernardi, Daniel Moura, Wellington S. Aguiar, Raimundo W. S. Oliveira, Ana C. S. S. Santos, Gil R. Alvarenga, Elson S. Oliveira, Eugenio E. Insects Article SIMPLE SUMMARY: Drosophila suzukii is an insect of global economic importance, including in the Neotropical region. Due to the difficulty in controlling this insect pest with conventional insecticidal molecules, it is necessary to search for novel alternatives. Here, we present the potential of synthetic lactone-based insecticides to control D. suzukii. Additionally, we demonstrate molecular predictions regarding the actions of these molecules on the nervous system of the target pest and on the nervous system of its parasitoid, Trichopria anastrephae. By using in silico approaches, we demonstrate that the lactone derivatives (rac)-8 and compound 4 predominantly affect the TRP channels of D. suzukii (TRPM) and exhibit less stable interactions with the TRP channels expressed in T. anastrephae. ABSTRACT: Drosophila suzukii, an invasive insect pest, poses a significant threat to various fruit crops. The use of broad-spectrum insecticides to control this pest can reduce the effectiveness of biological control agents, such as the parasitoid Trichopria anastrephae. Here, we evaluated the toxicity of newly synthesized lactone derivatives on D. suzukii and their selectivity towards T. anastrephae. We used in silico approaches to identify potential targets from the most promising molecules in the D. suzukii nervous system and to understand potential differences in susceptibilities between D. suzukii and its parasitoid. Of the nine molecules tested, (rac)-8 and compound 4 demonstrated efficacy against the fly. Exposure to the estimated LC(90) of (rac)-8 and compound 4 resulted in a mortality rate of less than 20% for T. anastrephae without impairing the parasitoid’s functional parasitism. The in silico predictions suggest that (rac)-8 and compound 4 target gamma amino butyric acid (GABA) receptors and transient receptor potential (TRP) channels of D. suzukii. However, only the reduced interaction with TRP channels in T. anastrephae demonstrated a potential reason for the selectivity of these compounds on the parasitoid. Our findings suggest the potential for integrating (rac)-8 and compound 4 into D. suzukii management practices. MDPI 2023-08-09 /pmc/articles/PMC10455539/ /pubmed/37623407 http://dx.doi.org/10.3390/insects14080697 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Mantilla Afanador, Javier G.
Araujo, Sabrina H. C.
Teixeira, Milena G.
Lopes, Dayane T.
Cerceau, Cristiane I.
Andreazza, Felipe
Oliveira, Daiana C.
Bernardi, Daniel
Moura, Wellington S.
Aguiar, Raimundo W. S.
Oliveira, Ana C. S. S.
Santos, Gil R.
Alvarenga, Elson S.
Oliveira, Eugenio E.
Novel Lactone-Based Insecticides and Drosophila suzukii Management: Synthesis, Potential Action Mechanisms and Selectivity for Non-Target Parasitoids
title Novel Lactone-Based Insecticides and Drosophila suzukii Management: Synthesis, Potential Action Mechanisms and Selectivity for Non-Target Parasitoids
title_full Novel Lactone-Based Insecticides and Drosophila suzukii Management: Synthesis, Potential Action Mechanisms and Selectivity for Non-Target Parasitoids
title_fullStr Novel Lactone-Based Insecticides and Drosophila suzukii Management: Synthesis, Potential Action Mechanisms and Selectivity for Non-Target Parasitoids
title_full_unstemmed Novel Lactone-Based Insecticides and Drosophila suzukii Management: Synthesis, Potential Action Mechanisms and Selectivity for Non-Target Parasitoids
title_short Novel Lactone-Based Insecticides and Drosophila suzukii Management: Synthesis, Potential Action Mechanisms and Selectivity for Non-Target Parasitoids
title_sort novel lactone-based insecticides and drosophila suzukii management: synthesis, potential action mechanisms and selectivity for non-target parasitoids
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10455539/
https://www.ncbi.nlm.nih.gov/pubmed/37623407
http://dx.doi.org/10.3390/insects14080697
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