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Extracellular Vesicles and Cancer Multidrug Resistance: Undesirable Intercellular Messengers?

Cancer multidrug resistance (MDR) is one of the main mechanisms contributing to therapy failure and mortality. Overexpression of drug transporters of the ABC family (ATP-binding cassette) is a major cause of MDR. Extracellular vesicles (EVs) are nanoparticles released by most cells of the organism i...

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Autores principales: Bucci-Muñoz, María, Gola, Aldana Magalí, Rigalli, Juan Pablo, Ceballos, María Paula, Ruiz, María Laura
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10455762/
https://www.ncbi.nlm.nih.gov/pubmed/37629489
http://dx.doi.org/10.3390/life13081633
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author Bucci-Muñoz, María
Gola, Aldana Magalí
Rigalli, Juan Pablo
Ceballos, María Paula
Ruiz, María Laura
author_facet Bucci-Muñoz, María
Gola, Aldana Magalí
Rigalli, Juan Pablo
Ceballos, María Paula
Ruiz, María Laura
author_sort Bucci-Muñoz, María
collection PubMed
description Cancer multidrug resistance (MDR) is one of the main mechanisms contributing to therapy failure and mortality. Overexpression of drug transporters of the ABC family (ATP-binding cassette) is a major cause of MDR. Extracellular vesicles (EVs) are nanoparticles released by most cells of the organism involved in cell–cell communication. Their cargo mainly comprises, proteins, nucleic acids, and lipids, which are transferred from a donor cell to a target cell and lead to phenotypical changes. In this article, we review the scientific evidence addressing the regulation of ABC transporters by EV-mediated cell–cell communication. MDR transfer from drug-resistant to drug-sensitive cells has been identified in several tumor entities. This was attributed, in some cases, to the direct shuttle of transporter molecules or its coding mRNA between cells. Also, EV-mediated transport of regulatory proteins (e.g., transcription factors) and noncoding RNAs have been indicated to induce MDR. Conversely, the transfer of a drug-sensitive phenotype via EVs has also been reported. Additionally, interactions between non-tumor cells and the tumor cells with an impact on MDR are presented. Finally, we highlight uninvestigated aspects and possible approaches to exploiting this knowledge toward the identification of druggable processes and molecules and, ultimately, the development of novel therapeutic strategies.
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spelling pubmed-104557622023-08-26 Extracellular Vesicles and Cancer Multidrug Resistance: Undesirable Intercellular Messengers? Bucci-Muñoz, María Gola, Aldana Magalí Rigalli, Juan Pablo Ceballos, María Paula Ruiz, María Laura Life (Basel) Review Cancer multidrug resistance (MDR) is one of the main mechanisms contributing to therapy failure and mortality. Overexpression of drug transporters of the ABC family (ATP-binding cassette) is a major cause of MDR. Extracellular vesicles (EVs) are nanoparticles released by most cells of the organism involved in cell–cell communication. Their cargo mainly comprises, proteins, nucleic acids, and lipids, which are transferred from a donor cell to a target cell and lead to phenotypical changes. In this article, we review the scientific evidence addressing the regulation of ABC transporters by EV-mediated cell–cell communication. MDR transfer from drug-resistant to drug-sensitive cells has been identified in several tumor entities. This was attributed, in some cases, to the direct shuttle of transporter molecules or its coding mRNA between cells. Also, EV-mediated transport of regulatory proteins (e.g., transcription factors) and noncoding RNAs have been indicated to induce MDR. Conversely, the transfer of a drug-sensitive phenotype via EVs has also been reported. Additionally, interactions between non-tumor cells and the tumor cells with an impact on MDR are presented. Finally, we highlight uninvestigated aspects and possible approaches to exploiting this knowledge toward the identification of druggable processes and molecules and, ultimately, the development of novel therapeutic strategies. MDPI 2023-07-27 /pmc/articles/PMC10455762/ /pubmed/37629489 http://dx.doi.org/10.3390/life13081633 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Bucci-Muñoz, María
Gola, Aldana Magalí
Rigalli, Juan Pablo
Ceballos, María Paula
Ruiz, María Laura
Extracellular Vesicles and Cancer Multidrug Resistance: Undesirable Intercellular Messengers?
title Extracellular Vesicles and Cancer Multidrug Resistance: Undesirable Intercellular Messengers?
title_full Extracellular Vesicles and Cancer Multidrug Resistance: Undesirable Intercellular Messengers?
title_fullStr Extracellular Vesicles and Cancer Multidrug Resistance: Undesirable Intercellular Messengers?
title_full_unstemmed Extracellular Vesicles and Cancer Multidrug Resistance: Undesirable Intercellular Messengers?
title_short Extracellular Vesicles and Cancer Multidrug Resistance: Undesirable Intercellular Messengers?
title_sort extracellular vesicles and cancer multidrug resistance: undesirable intercellular messengers?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10455762/
https://www.ncbi.nlm.nih.gov/pubmed/37629489
http://dx.doi.org/10.3390/life13081633
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