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Extracellular Vesicles and Cancer Multidrug Resistance: Undesirable Intercellular Messengers?
Cancer multidrug resistance (MDR) is one of the main mechanisms contributing to therapy failure and mortality. Overexpression of drug transporters of the ABC family (ATP-binding cassette) is a major cause of MDR. Extracellular vesicles (EVs) are nanoparticles released by most cells of the organism i...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10455762/ https://www.ncbi.nlm.nih.gov/pubmed/37629489 http://dx.doi.org/10.3390/life13081633 |
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author | Bucci-Muñoz, María Gola, Aldana Magalí Rigalli, Juan Pablo Ceballos, María Paula Ruiz, María Laura |
author_facet | Bucci-Muñoz, María Gola, Aldana Magalí Rigalli, Juan Pablo Ceballos, María Paula Ruiz, María Laura |
author_sort | Bucci-Muñoz, María |
collection | PubMed |
description | Cancer multidrug resistance (MDR) is one of the main mechanisms contributing to therapy failure and mortality. Overexpression of drug transporters of the ABC family (ATP-binding cassette) is a major cause of MDR. Extracellular vesicles (EVs) are nanoparticles released by most cells of the organism involved in cell–cell communication. Their cargo mainly comprises, proteins, nucleic acids, and lipids, which are transferred from a donor cell to a target cell and lead to phenotypical changes. In this article, we review the scientific evidence addressing the regulation of ABC transporters by EV-mediated cell–cell communication. MDR transfer from drug-resistant to drug-sensitive cells has been identified in several tumor entities. This was attributed, in some cases, to the direct shuttle of transporter molecules or its coding mRNA between cells. Also, EV-mediated transport of regulatory proteins (e.g., transcription factors) and noncoding RNAs have been indicated to induce MDR. Conversely, the transfer of a drug-sensitive phenotype via EVs has also been reported. Additionally, interactions between non-tumor cells and the tumor cells with an impact on MDR are presented. Finally, we highlight uninvestigated aspects and possible approaches to exploiting this knowledge toward the identification of druggable processes and molecules and, ultimately, the development of novel therapeutic strategies. |
format | Online Article Text |
id | pubmed-10455762 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-104557622023-08-26 Extracellular Vesicles and Cancer Multidrug Resistance: Undesirable Intercellular Messengers? Bucci-Muñoz, María Gola, Aldana Magalí Rigalli, Juan Pablo Ceballos, María Paula Ruiz, María Laura Life (Basel) Review Cancer multidrug resistance (MDR) is one of the main mechanisms contributing to therapy failure and mortality. Overexpression of drug transporters of the ABC family (ATP-binding cassette) is a major cause of MDR. Extracellular vesicles (EVs) are nanoparticles released by most cells of the organism involved in cell–cell communication. Their cargo mainly comprises, proteins, nucleic acids, and lipids, which are transferred from a donor cell to a target cell and lead to phenotypical changes. In this article, we review the scientific evidence addressing the regulation of ABC transporters by EV-mediated cell–cell communication. MDR transfer from drug-resistant to drug-sensitive cells has been identified in several tumor entities. This was attributed, in some cases, to the direct shuttle of transporter molecules or its coding mRNA between cells. Also, EV-mediated transport of regulatory proteins (e.g., transcription factors) and noncoding RNAs have been indicated to induce MDR. Conversely, the transfer of a drug-sensitive phenotype via EVs has also been reported. Additionally, interactions between non-tumor cells and the tumor cells with an impact on MDR are presented. Finally, we highlight uninvestigated aspects and possible approaches to exploiting this knowledge toward the identification of druggable processes and molecules and, ultimately, the development of novel therapeutic strategies. MDPI 2023-07-27 /pmc/articles/PMC10455762/ /pubmed/37629489 http://dx.doi.org/10.3390/life13081633 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Bucci-Muñoz, María Gola, Aldana Magalí Rigalli, Juan Pablo Ceballos, María Paula Ruiz, María Laura Extracellular Vesicles and Cancer Multidrug Resistance: Undesirable Intercellular Messengers? |
title | Extracellular Vesicles and Cancer Multidrug Resistance: Undesirable Intercellular Messengers? |
title_full | Extracellular Vesicles and Cancer Multidrug Resistance: Undesirable Intercellular Messengers? |
title_fullStr | Extracellular Vesicles and Cancer Multidrug Resistance: Undesirable Intercellular Messengers? |
title_full_unstemmed | Extracellular Vesicles and Cancer Multidrug Resistance: Undesirable Intercellular Messengers? |
title_short | Extracellular Vesicles and Cancer Multidrug Resistance: Undesirable Intercellular Messengers? |
title_sort | extracellular vesicles and cancer multidrug resistance: undesirable intercellular messengers? |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10455762/ https://www.ncbi.nlm.nih.gov/pubmed/37629489 http://dx.doi.org/10.3390/life13081633 |
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