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Gastrointestinal Stromal Tumors: Our Ten-Year Experience of a Single-Center Tertiary Hospital

Background: Gastrointestinal stromal tumors (GISTs) are the most frequent mesenchymal neoplasms of the gastrointestinal tract. They have variable clinical presentation, prognosis, and molecular characteristics. Here, we present the results of our retrospective study including patients operated on fo...

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Autores principales: Tzikos, Georgios, Menni, Alexandra-Eleftheria, Krokou, Despoina, Vouchara, Angeliki, Doutsini, Soultana, Karlafti, Eleni, Karakatsanis, Anestis, Ioannidis, Aristeidis, Panidis, Stavros, Papavramidis, Theodosios, Michalopoulos, Antonios, Paramythiotis, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10455766/
https://www.ncbi.nlm.nih.gov/pubmed/37623504
http://dx.doi.org/10.3390/jpm13081254
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author Tzikos, Georgios
Menni, Alexandra-Eleftheria
Krokou, Despoina
Vouchara, Angeliki
Doutsini, Soultana
Karlafti, Eleni
Karakatsanis, Anestis
Ioannidis, Aristeidis
Panidis, Stavros
Papavramidis, Theodosios
Michalopoulos, Antonios
Paramythiotis, Daniel
author_facet Tzikos, Georgios
Menni, Alexandra-Eleftheria
Krokou, Despoina
Vouchara, Angeliki
Doutsini, Soultana
Karlafti, Eleni
Karakatsanis, Anestis
Ioannidis, Aristeidis
Panidis, Stavros
Papavramidis, Theodosios
Michalopoulos, Antonios
Paramythiotis, Daniel
author_sort Tzikos, Georgios
collection PubMed
description Background: Gastrointestinal stromal tumors (GISTs) are the most frequent mesenchymal neoplasms of the gastrointestinal tract. They have variable clinical presentation, prognosis, and molecular characteristics. Here, we present the results of our retrospective study including patients operated on for GIST during the last decade. Methods: All the patients who underwent GIST resection during the decade 2008–2018 were included in the study. The diagnosis was based on the pathology report. All the data were collected and analyzed statistically using the Statistical Package for Social Science v25.0. Finally, after having applied the proper search terms, a comprehensive review of articles published in the Medline database was held. Results: Thirty-two patients (sixteen women) were included in the study with a mean age of 69.6 years old (SD = 13.9). Twenty-one patients had a GIST in the stomach, eight in the small intestine, and three had an extra GIST. Of the 29 patients contacted, 21 were alive with a mean survival time of 74.3 months (SD = 49.6 months, min: 3.0 months, max: 161.0 months), whereas eight patients passed away. Finally, 13 patients were treated with tyrosine kinase inhibitors (TKIs) of whom only one died, while 9 patients passed away from those treated with surgery alone (p = 0.031). Conclusions: Our results were in concordance with the existing data in the literature. GISTs require patient-based therapeutical management depending on the histology of the tumors. Gastric tumors present a better prognosis than those localized in the intestine, while the use of TKIs has led to an improvement in patient survival rate.
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spelling pubmed-104557662023-08-26 Gastrointestinal Stromal Tumors: Our Ten-Year Experience of a Single-Center Tertiary Hospital Tzikos, Georgios Menni, Alexandra-Eleftheria Krokou, Despoina Vouchara, Angeliki Doutsini, Soultana Karlafti, Eleni Karakatsanis, Anestis Ioannidis, Aristeidis Panidis, Stavros Papavramidis, Theodosios Michalopoulos, Antonios Paramythiotis, Daniel J Pers Med Article Background: Gastrointestinal stromal tumors (GISTs) are the most frequent mesenchymal neoplasms of the gastrointestinal tract. They have variable clinical presentation, prognosis, and molecular characteristics. Here, we present the results of our retrospective study including patients operated on for GIST during the last decade. Methods: All the patients who underwent GIST resection during the decade 2008–2018 were included in the study. The diagnosis was based on the pathology report. All the data were collected and analyzed statistically using the Statistical Package for Social Science v25.0. Finally, after having applied the proper search terms, a comprehensive review of articles published in the Medline database was held. Results: Thirty-two patients (sixteen women) were included in the study with a mean age of 69.6 years old (SD = 13.9). Twenty-one patients had a GIST in the stomach, eight in the small intestine, and three had an extra GIST. Of the 29 patients contacted, 21 were alive with a mean survival time of 74.3 months (SD = 49.6 months, min: 3.0 months, max: 161.0 months), whereas eight patients passed away. Finally, 13 patients were treated with tyrosine kinase inhibitors (TKIs) of whom only one died, while 9 patients passed away from those treated with surgery alone (p = 0.031). Conclusions: Our results were in concordance with the existing data in the literature. GISTs require patient-based therapeutical management depending on the histology of the tumors. Gastric tumors present a better prognosis than those localized in the intestine, while the use of TKIs has led to an improvement in patient survival rate. MDPI 2023-08-13 /pmc/articles/PMC10455766/ /pubmed/37623504 http://dx.doi.org/10.3390/jpm13081254 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Tzikos, Georgios
Menni, Alexandra-Eleftheria
Krokou, Despoina
Vouchara, Angeliki
Doutsini, Soultana
Karlafti, Eleni
Karakatsanis, Anestis
Ioannidis, Aristeidis
Panidis, Stavros
Papavramidis, Theodosios
Michalopoulos, Antonios
Paramythiotis, Daniel
Gastrointestinal Stromal Tumors: Our Ten-Year Experience of a Single-Center Tertiary Hospital
title Gastrointestinal Stromal Tumors: Our Ten-Year Experience of a Single-Center Tertiary Hospital
title_full Gastrointestinal Stromal Tumors: Our Ten-Year Experience of a Single-Center Tertiary Hospital
title_fullStr Gastrointestinal Stromal Tumors: Our Ten-Year Experience of a Single-Center Tertiary Hospital
title_full_unstemmed Gastrointestinal Stromal Tumors: Our Ten-Year Experience of a Single-Center Tertiary Hospital
title_short Gastrointestinal Stromal Tumors: Our Ten-Year Experience of a Single-Center Tertiary Hospital
title_sort gastrointestinal stromal tumors: our ten-year experience of a single-center tertiary hospital
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10455766/
https://www.ncbi.nlm.nih.gov/pubmed/37623504
http://dx.doi.org/10.3390/jpm13081254
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