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Gastrointestinal Stromal Tumors: Our Ten-Year Experience of a Single-Center Tertiary Hospital
Background: Gastrointestinal stromal tumors (GISTs) are the most frequent mesenchymal neoplasms of the gastrointestinal tract. They have variable clinical presentation, prognosis, and molecular characteristics. Here, we present the results of our retrospective study including patients operated on fo...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10455766/ https://www.ncbi.nlm.nih.gov/pubmed/37623504 http://dx.doi.org/10.3390/jpm13081254 |
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author | Tzikos, Georgios Menni, Alexandra-Eleftheria Krokou, Despoina Vouchara, Angeliki Doutsini, Soultana Karlafti, Eleni Karakatsanis, Anestis Ioannidis, Aristeidis Panidis, Stavros Papavramidis, Theodosios Michalopoulos, Antonios Paramythiotis, Daniel |
author_facet | Tzikos, Georgios Menni, Alexandra-Eleftheria Krokou, Despoina Vouchara, Angeliki Doutsini, Soultana Karlafti, Eleni Karakatsanis, Anestis Ioannidis, Aristeidis Panidis, Stavros Papavramidis, Theodosios Michalopoulos, Antonios Paramythiotis, Daniel |
author_sort | Tzikos, Georgios |
collection | PubMed |
description | Background: Gastrointestinal stromal tumors (GISTs) are the most frequent mesenchymal neoplasms of the gastrointestinal tract. They have variable clinical presentation, prognosis, and molecular characteristics. Here, we present the results of our retrospective study including patients operated on for GIST during the last decade. Methods: All the patients who underwent GIST resection during the decade 2008–2018 were included in the study. The diagnosis was based on the pathology report. All the data were collected and analyzed statistically using the Statistical Package for Social Science v25.0. Finally, after having applied the proper search terms, a comprehensive review of articles published in the Medline database was held. Results: Thirty-two patients (sixteen women) were included in the study with a mean age of 69.6 years old (SD = 13.9). Twenty-one patients had a GIST in the stomach, eight in the small intestine, and three had an extra GIST. Of the 29 patients contacted, 21 were alive with a mean survival time of 74.3 months (SD = 49.6 months, min: 3.0 months, max: 161.0 months), whereas eight patients passed away. Finally, 13 patients were treated with tyrosine kinase inhibitors (TKIs) of whom only one died, while 9 patients passed away from those treated with surgery alone (p = 0.031). Conclusions: Our results were in concordance with the existing data in the literature. GISTs require patient-based therapeutical management depending on the histology of the tumors. Gastric tumors present a better prognosis than those localized in the intestine, while the use of TKIs has led to an improvement in patient survival rate. |
format | Online Article Text |
id | pubmed-10455766 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-104557662023-08-26 Gastrointestinal Stromal Tumors: Our Ten-Year Experience of a Single-Center Tertiary Hospital Tzikos, Georgios Menni, Alexandra-Eleftheria Krokou, Despoina Vouchara, Angeliki Doutsini, Soultana Karlafti, Eleni Karakatsanis, Anestis Ioannidis, Aristeidis Panidis, Stavros Papavramidis, Theodosios Michalopoulos, Antonios Paramythiotis, Daniel J Pers Med Article Background: Gastrointestinal stromal tumors (GISTs) are the most frequent mesenchymal neoplasms of the gastrointestinal tract. They have variable clinical presentation, prognosis, and molecular characteristics. Here, we present the results of our retrospective study including patients operated on for GIST during the last decade. Methods: All the patients who underwent GIST resection during the decade 2008–2018 were included in the study. The diagnosis was based on the pathology report. All the data were collected and analyzed statistically using the Statistical Package for Social Science v25.0. Finally, after having applied the proper search terms, a comprehensive review of articles published in the Medline database was held. Results: Thirty-two patients (sixteen women) were included in the study with a mean age of 69.6 years old (SD = 13.9). Twenty-one patients had a GIST in the stomach, eight in the small intestine, and three had an extra GIST. Of the 29 patients contacted, 21 were alive with a mean survival time of 74.3 months (SD = 49.6 months, min: 3.0 months, max: 161.0 months), whereas eight patients passed away. Finally, 13 patients were treated with tyrosine kinase inhibitors (TKIs) of whom only one died, while 9 patients passed away from those treated with surgery alone (p = 0.031). Conclusions: Our results were in concordance with the existing data in the literature. GISTs require patient-based therapeutical management depending on the histology of the tumors. Gastric tumors present a better prognosis than those localized in the intestine, while the use of TKIs has led to an improvement in patient survival rate. MDPI 2023-08-13 /pmc/articles/PMC10455766/ /pubmed/37623504 http://dx.doi.org/10.3390/jpm13081254 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Tzikos, Georgios Menni, Alexandra-Eleftheria Krokou, Despoina Vouchara, Angeliki Doutsini, Soultana Karlafti, Eleni Karakatsanis, Anestis Ioannidis, Aristeidis Panidis, Stavros Papavramidis, Theodosios Michalopoulos, Antonios Paramythiotis, Daniel Gastrointestinal Stromal Tumors: Our Ten-Year Experience of a Single-Center Tertiary Hospital |
title | Gastrointestinal Stromal Tumors: Our Ten-Year Experience of a Single-Center Tertiary Hospital |
title_full | Gastrointestinal Stromal Tumors: Our Ten-Year Experience of a Single-Center Tertiary Hospital |
title_fullStr | Gastrointestinal Stromal Tumors: Our Ten-Year Experience of a Single-Center Tertiary Hospital |
title_full_unstemmed | Gastrointestinal Stromal Tumors: Our Ten-Year Experience of a Single-Center Tertiary Hospital |
title_short | Gastrointestinal Stromal Tumors: Our Ten-Year Experience of a Single-Center Tertiary Hospital |
title_sort | gastrointestinal stromal tumors: our ten-year experience of a single-center tertiary hospital |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10455766/ https://www.ncbi.nlm.nih.gov/pubmed/37623504 http://dx.doi.org/10.3390/jpm13081254 |
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