Cargando…
A New Mild Method for Synthesis of Marine Alkaloid Fascaplysin and Its Therapeutically Promising Derivatives
Fascaplysin is a marine alkaloid which is considered to be a lead drug candidate due to its diverse and potent biological activity. As an anticancer agent, fascaplysin holds a great potential due to the multiple targets affected by this alkaloid in cancer cells, including inhibition of cyclin-depend...
Autores principales: | Tryapkin, Oleg A., Kantemirov, Alexey V., Dyshlovoy, Sergey A., Prassolov, Vladimir S., Spirin, Pavel V., von Amsberg, Gunhild, Sidorova, Maria A., Zhidkov, Maxim E. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10455802/ https://www.ncbi.nlm.nih.gov/pubmed/37623705 http://dx.doi.org/10.3390/md21080424 |
Ejemplares similares
-
Study of Structure–Activity Relationships of the Marine Alkaloid Fascaplysin and Its Derivatives as Potent Anticancer Agents
por: Zhidkov, Maxim E., et al.
Publicado: (2022) -
Total Syntheses and Preliminary Biological Evaluation of Brominated Fascaplysin and Reticulatine Alkaloids and Their Analogues
por: Zhidkov, Maxim E., et al.
Publicado: (2019) -
Cytotoxic Marine Alkaloid 3,10-Dibromofascaplysin Induces Apoptosis and Synergizes with Cytarabine Resulting in Leukemia Cell Death
por: Spirin, Pavel, et al.
Publicado: (2021) -
Efficacy and Mechanism of Action of Marine Alkaloid 3,10-Dibromofascaplysin in Drug-Resistant Prostate Cancer Cells
por: Dyshlovoy, Sergey A., et al.
Publicado: (2020) -
Alkaloids of fascaplysin are effective conventional chemotherapeutic drugs, inhibiting the proliferation of C6 glioma cells and causing their death in vitro
por: Bryukhovetskiy, Igor, et al.
Publicado: (2017)