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Causes of Non-Adherence to Allergen-Specific Immunotherapy: A Foundation towards a Patient-Personalized Approach

Background. Allergen-specific immunotherapy (AIT) is the only disease-modifying therapy for allergic conditions, resulting in a long-lasting tolerance beyond the duration of the treatment. Due to the strong relationship between the effectiveness, its optimal duration (at least three years) and the o...

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Autores principales: Ridolo, Erminia, Nicoletta, Francesca, Barone, Alessandro, Ottoni, Martina, Senna, Gianenrico, Canonica, Giorgio Walter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10455852/
https://www.ncbi.nlm.nih.gov/pubmed/37623457
http://dx.doi.org/10.3390/jpm13081206
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author Ridolo, Erminia
Nicoletta, Francesca
Barone, Alessandro
Ottoni, Martina
Senna, Gianenrico
Canonica, Giorgio Walter
author_facet Ridolo, Erminia
Nicoletta, Francesca
Barone, Alessandro
Ottoni, Martina
Senna, Gianenrico
Canonica, Giorgio Walter
author_sort Ridolo, Erminia
collection PubMed
description Background. Allergen-specific immunotherapy (AIT) is the only disease-modifying therapy for allergic conditions, resulting in a long-lasting tolerance beyond the duration of the treatment. Due to the strong relationship between the effectiveness, its optimal duration (at least three years) and the observation of the correct administration protocol, appropriate adherence to the plan of treatment represents a critical factor for the therapeutical success of AIT. Methods. Analysis of studies about the rate of adherence in subcutaneous and sublingual immunotherapy, which are the main routes of administration of AIT. Results. There are different causes leading to a premature interruption of the therapy or to it being incorrectly carried out; the most reported include erroneous expectations of the effectiveness and the adverse effects, economic issues, inconvenience and unrelated clinical conditions. Conclusions. An attentive analysis of the main causes of dropouts may be useful to improve the management of these patients and to develop new strategies for a personalized approach. These strategies should be dynamic, involving attentive communication between the physician and the patient about all the possible criticalities, especially in the initial phase of the therapy, and facilitating, as much as possible, access to healthcare providers over the course of the maintenance phase, including by exploiting technological tools.
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spelling pubmed-104558522023-08-26 Causes of Non-Adherence to Allergen-Specific Immunotherapy: A Foundation towards a Patient-Personalized Approach Ridolo, Erminia Nicoletta, Francesca Barone, Alessandro Ottoni, Martina Senna, Gianenrico Canonica, Giorgio Walter J Pers Med Review Background. Allergen-specific immunotherapy (AIT) is the only disease-modifying therapy for allergic conditions, resulting in a long-lasting tolerance beyond the duration of the treatment. Due to the strong relationship between the effectiveness, its optimal duration (at least three years) and the observation of the correct administration protocol, appropriate adherence to the plan of treatment represents a critical factor for the therapeutical success of AIT. Methods. Analysis of studies about the rate of adherence in subcutaneous and sublingual immunotherapy, which are the main routes of administration of AIT. Results. There are different causes leading to a premature interruption of the therapy or to it being incorrectly carried out; the most reported include erroneous expectations of the effectiveness and the adverse effects, economic issues, inconvenience and unrelated clinical conditions. Conclusions. An attentive analysis of the main causes of dropouts may be useful to improve the management of these patients and to develop new strategies for a personalized approach. These strategies should be dynamic, involving attentive communication between the physician and the patient about all the possible criticalities, especially in the initial phase of the therapy, and facilitating, as much as possible, access to healthcare providers over the course of the maintenance phase, including by exploiting technological tools. MDPI 2023-07-29 /pmc/articles/PMC10455852/ /pubmed/37623457 http://dx.doi.org/10.3390/jpm13081206 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Ridolo, Erminia
Nicoletta, Francesca
Barone, Alessandro
Ottoni, Martina
Senna, Gianenrico
Canonica, Giorgio Walter
Causes of Non-Adherence to Allergen-Specific Immunotherapy: A Foundation towards a Patient-Personalized Approach
title Causes of Non-Adherence to Allergen-Specific Immunotherapy: A Foundation towards a Patient-Personalized Approach
title_full Causes of Non-Adherence to Allergen-Specific Immunotherapy: A Foundation towards a Patient-Personalized Approach
title_fullStr Causes of Non-Adherence to Allergen-Specific Immunotherapy: A Foundation towards a Patient-Personalized Approach
title_full_unstemmed Causes of Non-Adherence to Allergen-Specific Immunotherapy: A Foundation towards a Patient-Personalized Approach
title_short Causes of Non-Adherence to Allergen-Specific Immunotherapy: A Foundation towards a Patient-Personalized Approach
title_sort causes of non-adherence to allergen-specific immunotherapy: a foundation towards a patient-personalized approach
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10455852/
https://www.ncbi.nlm.nih.gov/pubmed/37623457
http://dx.doi.org/10.3390/jpm13081206
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