Cargando…
Remimazolam’s Effects on Postoperative Nausea and Vomiting Are Similar to Those of Propofol after Laparoscopic Gynecological Surgery: A Randomized Controlled Trial
(1) Background: Remimazolam is a novel benzodiazepine that prevents postoperative nausea and vomiting (PONV), is more effective than volatile anesthetics, and was recently approved for use in Japan. (2) Methods: This prospective, double-blind, randomized controlled trial study aimed to compare the e...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10455908/ https://www.ncbi.nlm.nih.gov/pubmed/37629444 http://dx.doi.org/10.3390/jcm12165402 |
_version_ | 1785096565618114560 |
---|---|
author | Matsumoto, Ayumu Satomi, Shiho Kakuta, Nami Narasaki, Soshi Toyota, Yukari Miyoshi, Hirotsugu Horikawa, Yousuke T. Saeki, Noboru Tanaka, Katsuya Tsutsumi, Yasuo M. |
author_facet | Matsumoto, Ayumu Satomi, Shiho Kakuta, Nami Narasaki, Soshi Toyota, Yukari Miyoshi, Hirotsugu Horikawa, Yousuke T. Saeki, Noboru Tanaka, Katsuya Tsutsumi, Yasuo M. |
author_sort | Matsumoto, Ayumu |
collection | PubMed |
description | (1) Background: Remimazolam is a novel benzodiazepine that prevents postoperative nausea and vomiting (PONV), is more effective than volatile anesthetics, and was recently approved for use in Japan. (2) Methods: This prospective, double-blind, randomized controlled trial study aimed to compare the efficacy of remimazolam and propofol as general anesthetics in terms of the incidence of PONV after laparoscopic gynecological surgery (UMIN000046237). High-risk female patients who underwent general anesthesia with either remimazolam or propofol for the maintenance of anesthesia were enrolled. The primary outcome was the incidence of PONV in the two groups (i.e., REM versus PROP) 2 h and 24 h after surgery. The incidence of vomiting without nausea, rescue antiemetic use, and the severity of nausea were also evaluated. (3) Results: No significant differences in PONV were identified between the REM and PROP groups at 2 h or 24 h. Furthermore, no differences were observed in any of the measured parameters, and no adverse events were reported. (4) Conclusions: The results of the present study suggest that remimazolam may be as effective as propofol in preventing PONV; however, further investigation is necessary to identify possible differences between these two agents. |
format | Online Article Text |
id | pubmed-10455908 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-104559082023-08-26 Remimazolam’s Effects on Postoperative Nausea and Vomiting Are Similar to Those of Propofol after Laparoscopic Gynecological Surgery: A Randomized Controlled Trial Matsumoto, Ayumu Satomi, Shiho Kakuta, Nami Narasaki, Soshi Toyota, Yukari Miyoshi, Hirotsugu Horikawa, Yousuke T. Saeki, Noboru Tanaka, Katsuya Tsutsumi, Yasuo M. J Clin Med Brief Report (1) Background: Remimazolam is a novel benzodiazepine that prevents postoperative nausea and vomiting (PONV), is more effective than volatile anesthetics, and was recently approved for use in Japan. (2) Methods: This prospective, double-blind, randomized controlled trial study aimed to compare the efficacy of remimazolam and propofol as general anesthetics in terms of the incidence of PONV after laparoscopic gynecological surgery (UMIN000046237). High-risk female patients who underwent general anesthesia with either remimazolam or propofol for the maintenance of anesthesia were enrolled. The primary outcome was the incidence of PONV in the two groups (i.e., REM versus PROP) 2 h and 24 h after surgery. The incidence of vomiting without nausea, rescue antiemetic use, and the severity of nausea were also evaluated. (3) Results: No significant differences in PONV were identified between the REM and PROP groups at 2 h or 24 h. Furthermore, no differences were observed in any of the measured parameters, and no adverse events were reported. (4) Conclusions: The results of the present study suggest that remimazolam may be as effective as propofol in preventing PONV; however, further investigation is necessary to identify possible differences between these two agents. MDPI 2023-08-20 /pmc/articles/PMC10455908/ /pubmed/37629444 http://dx.doi.org/10.3390/jcm12165402 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Brief Report Matsumoto, Ayumu Satomi, Shiho Kakuta, Nami Narasaki, Soshi Toyota, Yukari Miyoshi, Hirotsugu Horikawa, Yousuke T. Saeki, Noboru Tanaka, Katsuya Tsutsumi, Yasuo M. Remimazolam’s Effects on Postoperative Nausea and Vomiting Are Similar to Those of Propofol after Laparoscopic Gynecological Surgery: A Randomized Controlled Trial |
title | Remimazolam’s Effects on Postoperative Nausea and Vomiting Are Similar to Those of Propofol after Laparoscopic Gynecological Surgery: A Randomized Controlled Trial |
title_full | Remimazolam’s Effects on Postoperative Nausea and Vomiting Are Similar to Those of Propofol after Laparoscopic Gynecological Surgery: A Randomized Controlled Trial |
title_fullStr | Remimazolam’s Effects on Postoperative Nausea and Vomiting Are Similar to Those of Propofol after Laparoscopic Gynecological Surgery: A Randomized Controlled Trial |
title_full_unstemmed | Remimazolam’s Effects on Postoperative Nausea and Vomiting Are Similar to Those of Propofol after Laparoscopic Gynecological Surgery: A Randomized Controlled Trial |
title_short | Remimazolam’s Effects on Postoperative Nausea and Vomiting Are Similar to Those of Propofol after Laparoscopic Gynecological Surgery: A Randomized Controlled Trial |
title_sort | remimazolam’s effects on postoperative nausea and vomiting are similar to those of propofol after laparoscopic gynecological surgery: a randomized controlled trial |
topic | Brief Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10455908/ https://www.ncbi.nlm.nih.gov/pubmed/37629444 http://dx.doi.org/10.3390/jcm12165402 |
work_keys_str_mv | AT matsumotoayumu remimazolamseffectsonpostoperativenauseaandvomitingaresimilartothoseofpropofolafterlaparoscopicgynecologicalsurgeryarandomizedcontrolledtrial AT satomishiho remimazolamseffectsonpostoperativenauseaandvomitingaresimilartothoseofpropofolafterlaparoscopicgynecologicalsurgeryarandomizedcontrolledtrial AT kakutanami remimazolamseffectsonpostoperativenauseaandvomitingaresimilartothoseofpropofolafterlaparoscopicgynecologicalsurgeryarandomizedcontrolledtrial AT narasakisoshi remimazolamseffectsonpostoperativenauseaandvomitingaresimilartothoseofpropofolafterlaparoscopicgynecologicalsurgeryarandomizedcontrolledtrial AT toyotayukari remimazolamseffectsonpostoperativenauseaandvomitingaresimilartothoseofpropofolafterlaparoscopicgynecologicalsurgeryarandomizedcontrolledtrial AT miyoshihirotsugu remimazolamseffectsonpostoperativenauseaandvomitingaresimilartothoseofpropofolafterlaparoscopicgynecologicalsurgeryarandomizedcontrolledtrial AT horikawayousuket remimazolamseffectsonpostoperativenauseaandvomitingaresimilartothoseofpropofolafterlaparoscopicgynecologicalsurgeryarandomizedcontrolledtrial AT saekinoboru remimazolamseffectsonpostoperativenauseaandvomitingaresimilartothoseofpropofolafterlaparoscopicgynecologicalsurgeryarandomizedcontrolledtrial AT tanakakatsuya remimazolamseffectsonpostoperativenauseaandvomitingaresimilartothoseofpropofolafterlaparoscopicgynecologicalsurgeryarandomizedcontrolledtrial AT tsutsumiyasuom remimazolamseffectsonpostoperativenauseaandvomitingaresimilartothoseofpropofolafterlaparoscopicgynecologicalsurgeryarandomizedcontrolledtrial |