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Evaluation of Retinal Blood Flow in Patients with Monoclonal Gammopathy Using OCT Angiography
Background: Monoclonal gammopathy (MG) is characterized by monoclonal protein overproduction, potentially leading to the development of hyperviscosity syndrome. Objective: To assess retinal circulation using optical coherence tomography angiography (OCTA) parameters in patients with monoclonal gammo...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10456010/ https://www.ncbi.nlm.nih.gov/pubmed/37629268 http://dx.doi.org/10.3390/jcm12165227 |
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author | Czakó, Cecilia Gerencsér, Dóra Kormányos, Kitti Kéki-Kovács, Klaudia Németh, Orsolya Tóth, Gábor Sándor, Gábor László Csorba, Anita Langenbucher, Achim Nagy, Zoltán Zsolt Varga, Gergely Gopcsa, László Mikala, Gábor Kovács, Illés Szentmáry, Nóra |
author_facet | Czakó, Cecilia Gerencsér, Dóra Kormányos, Kitti Kéki-Kovács, Klaudia Németh, Orsolya Tóth, Gábor Sándor, Gábor László Csorba, Anita Langenbucher, Achim Nagy, Zoltán Zsolt Varga, Gergely Gopcsa, László Mikala, Gábor Kovács, Illés Szentmáry, Nóra |
author_sort | Czakó, Cecilia |
collection | PubMed |
description | Background: Monoclonal gammopathy (MG) is characterized by monoclonal protein overproduction, potentially leading to the development of hyperviscosity syndrome. Objective: To assess retinal circulation using optical coherence tomography angiography (OCTA) parameters in patients with monoclonal gammopathy. Methods: OCTA measurements were performed using the Optovue AngioVue system by examining 44 eyes of 27 patients with MG and 62 eyes of 36 control subjects. Superficial and deep retinal capillary vessel density (VD SVP and DVP) in the whole 3 × 3 mm macular and parafoveal area, foveal avascular zone (FAZ) area, and central retinal thickness (CRT) were measured using the AngioAnalytics software. The OCTA parameters were evaluated in both groups using a multivariate regression model, after controlling for the effect of imaging quality (SQ). Results: There was no significant difference in age between the subjects with monoclonal gammopathy and the controls (63.59 ± 9.33 vs. 58.01 ± 11.46 years; p > 0.05). Taking into account the effect of image quality, the VD SVP was significantly lower in the MG group compared to the control group (44.54 ± 3.22% vs. 46.62 ± 2.84%; p < 0.05). No significant differences were found between the two groups regarding the other OCTA parameters (p > 0.05). Conclusions: A decreased superficial retinal capillary vessel density measured using OCTA in patients with MG suggests a slow blood flow, reduced capillary circulation, and consequent tissue hypoperfusion. An evaluation of retinal circulation using OCTA in cases of monoclonal gammopathy may be a sensitive method for the non-invasive detection and follow-up of early microcirculatory dysfunction caused by increased viscosity. |
format | Online Article Text |
id | pubmed-10456010 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-104560102023-08-26 Evaluation of Retinal Blood Flow in Patients with Monoclonal Gammopathy Using OCT Angiography Czakó, Cecilia Gerencsér, Dóra Kormányos, Kitti Kéki-Kovács, Klaudia Németh, Orsolya Tóth, Gábor Sándor, Gábor László Csorba, Anita Langenbucher, Achim Nagy, Zoltán Zsolt Varga, Gergely Gopcsa, László Mikala, Gábor Kovács, Illés Szentmáry, Nóra J Clin Med Article Background: Monoclonal gammopathy (MG) is characterized by monoclonal protein overproduction, potentially leading to the development of hyperviscosity syndrome. Objective: To assess retinal circulation using optical coherence tomography angiography (OCTA) parameters in patients with monoclonal gammopathy. Methods: OCTA measurements were performed using the Optovue AngioVue system by examining 44 eyes of 27 patients with MG and 62 eyes of 36 control subjects. Superficial and deep retinal capillary vessel density (VD SVP and DVP) in the whole 3 × 3 mm macular and parafoveal area, foveal avascular zone (FAZ) area, and central retinal thickness (CRT) were measured using the AngioAnalytics software. The OCTA parameters were evaluated in both groups using a multivariate regression model, after controlling for the effect of imaging quality (SQ). Results: There was no significant difference in age between the subjects with monoclonal gammopathy and the controls (63.59 ± 9.33 vs. 58.01 ± 11.46 years; p > 0.05). Taking into account the effect of image quality, the VD SVP was significantly lower in the MG group compared to the control group (44.54 ± 3.22% vs. 46.62 ± 2.84%; p < 0.05). No significant differences were found between the two groups regarding the other OCTA parameters (p > 0.05). Conclusions: A decreased superficial retinal capillary vessel density measured using OCTA in patients with MG suggests a slow blood flow, reduced capillary circulation, and consequent tissue hypoperfusion. An evaluation of retinal circulation using OCTA in cases of monoclonal gammopathy may be a sensitive method for the non-invasive detection and follow-up of early microcirculatory dysfunction caused by increased viscosity. MDPI 2023-08-11 /pmc/articles/PMC10456010/ /pubmed/37629268 http://dx.doi.org/10.3390/jcm12165227 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Czakó, Cecilia Gerencsér, Dóra Kormányos, Kitti Kéki-Kovács, Klaudia Németh, Orsolya Tóth, Gábor Sándor, Gábor László Csorba, Anita Langenbucher, Achim Nagy, Zoltán Zsolt Varga, Gergely Gopcsa, László Mikala, Gábor Kovács, Illés Szentmáry, Nóra Evaluation of Retinal Blood Flow in Patients with Monoclonal Gammopathy Using OCT Angiography |
title | Evaluation of Retinal Blood Flow in Patients with Monoclonal Gammopathy Using OCT Angiography |
title_full | Evaluation of Retinal Blood Flow in Patients with Monoclonal Gammopathy Using OCT Angiography |
title_fullStr | Evaluation of Retinal Blood Flow in Patients with Monoclonal Gammopathy Using OCT Angiography |
title_full_unstemmed | Evaluation of Retinal Blood Flow in Patients with Monoclonal Gammopathy Using OCT Angiography |
title_short | Evaluation of Retinal Blood Flow in Patients with Monoclonal Gammopathy Using OCT Angiography |
title_sort | evaluation of retinal blood flow in patients with monoclonal gammopathy using oct angiography |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10456010/ https://www.ncbi.nlm.nih.gov/pubmed/37629268 http://dx.doi.org/10.3390/jcm12165227 |
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