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Fetal Cardiac Hemodynamic and Sonographic Anomalies in Maternal COVID-19 Infection Depending on Vaccination Status—Polish Multicenter Cohort Study

Most obstetrical studies have focused on maternal response to the SARS-CoV-2 virus but much less is known about the effect of COVID-19 on fetal physiology. We aimed to evaluate the effect of the maternal SARS-CoV-2 infection on the fetal homeostasis with the use of detailed ultrasonography and echoc...

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Autores principales: Strzelecka, Iwona, Sylwestrzak, Oskar, Murlewska, Julia, Węgrzynowski, Jerzy, Leszczyńska, Katarzyna, Preis, Krzysztof, Respondek-Liberska, Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10456038/
https://www.ncbi.nlm.nih.gov/pubmed/37629228
http://dx.doi.org/10.3390/jcm12165186
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author Strzelecka, Iwona
Sylwestrzak, Oskar
Murlewska, Julia
Węgrzynowski, Jerzy
Leszczyńska, Katarzyna
Preis, Krzysztof
Respondek-Liberska, Maria
author_facet Strzelecka, Iwona
Sylwestrzak, Oskar
Murlewska, Julia
Węgrzynowski, Jerzy
Leszczyńska, Katarzyna
Preis, Krzysztof
Respondek-Liberska, Maria
author_sort Strzelecka, Iwona
collection PubMed
description Most obstetrical studies have focused on maternal response to the SARS-CoV-2 virus but much less is known about the effect of COVID-19 on fetal physiology. We aimed to evaluate the effect of the maternal SARS-CoV-2 infection on the fetal homeostasis with the use of detailed ultrasonography and echocardiography and consideration of the effect of vaccination. This was a multi-center study of fetuses who had prenatal detailed ultrasound and echocardiographic examinations performed by fetal cardiology specialists. The subjects were divided based on the COVID vaccination status (vaccinated women who did not have COVID-group V, unvaccinated women who had COVID-group UV, and unvaccinated women who did not have COVID-control group). We evaluated the ultrasound and echocardiography results obtained. The study group included 237 gravidas from four prenatal cardiology centers. In the group of fetuses with normal heart anatomy, normal cardiovascular function had 147 (81%) fetuses and functional cardiovascular anomalies were present in 35 (19%) cases. Functional cardiovascular anomalies were present in 11 (16%) fetuses in the V group, 19 (47%) fetuses in the UV group and 5 (8%) fetuses in the control group (p < 0.01). There were 56 (24%) fetuses with extracardiac anomalies. Extracardiac anomalies were present in 20 (22%) fetuses in the V group, 22 (45%) fetuses of the UV group and in 14 (14%) fetuses in the control group (p < 0.01). Our study has proved that maternal COVID-19 infection can affect the fetal physiology and mild cardiac and extracardiac markers detected by fetal ultrasonography and echocardiography. Moreover, maternal vaccination results in lower occurrence of these findings in fetuses.
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spelling pubmed-104560382023-08-26 Fetal Cardiac Hemodynamic and Sonographic Anomalies in Maternal COVID-19 Infection Depending on Vaccination Status—Polish Multicenter Cohort Study Strzelecka, Iwona Sylwestrzak, Oskar Murlewska, Julia Węgrzynowski, Jerzy Leszczyńska, Katarzyna Preis, Krzysztof Respondek-Liberska, Maria J Clin Med Article Most obstetrical studies have focused on maternal response to the SARS-CoV-2 virus but much less is known about the effect of COVID-19 on fetal physiology. We aimed to evaluate the effect of the maternal SARS-CoV-2 infection on the fetal homeostasis with the use of detailed ultrasonography and echocardiography and consideration of the effect of vaccination. This was a multi-center study of fetuses who had prenatal detailed ultrasound and echocardiographic examinations performed by fetal cardiology specialists. The subjects were divided based on the COVID vaccination status (vaccinated women who did not have COVID-group V, unvaccinated women who had COVID-group UV, and unvaccinated women who did not have COVID-control group). We evaluated the ultrasound and echocardiography results obtained. The study group included 237 gravidas from four prenatal cardiology centers. In the group of fetuses with normal heart anatomy, normal cardiovascular function had 147 (81%) fetuses and functional cardiovascular anomalies were present in 35 (19%) cases. Functional cardiovascular anomalies were present in 11 (16%) fetuses in the V group, 19 (47%) fetuses in the UV group and 5 (8%) fetuses in the control group (p < 0.01). There were 56 (24%) fetuses with extracardiac anomalies. Extracardiac anomalies were present in 20 (22%) fetuses in the V group, 22 (45%) fetuses of the UV group and in 14 (14%) fetuses in the control group (p < 0.01). Our study has proved that maternal COVID-19 infection can affect the fetal physiology and mild cardiac and extracardiac markers detected by fetal ultrasonography and echocardiography. Moreover, maternal vaccination results in lower occurrence of these findings in fetuses. MDPI 2023-08-09 /pmc/articles/PMC10456038/ /pubmed/37629228 http://dx.doi.org/10.3390/jcm12165186 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Strzelecka, Iwona
Sylwestrzak, Oskar
Murlewska, Julia
Węgrzynowski, Jerzy
Leszczyńska, Katarzyna
Preis, Krzysztof
Respondek-Liberska, Maria
Fetal Cardiac Hemodynamic and Sonographic Anomalies in Maternal COVID-19 Infection Depending on Vaccination Status—Polish Multicenter Cohort Study
title Fetal Cardiac Hemodynamic and Sonographic Anomalies in Maternal COVID-19 Infection Depending on Vaccination Status—Polish Multicenter Cohort Study
title_full Fetal Cardiac Hemodynamic and Sonographic Anomalies in Maternal COVID-19 Infection Depending on Vaccination Status—Polish Multicenter Cohort Study
title_fullStr Fetal Cardiac Hemodynamic and Sonographic Anomalies in Maternal COVID-19 Infection Depending on Vaccination Status—Polish Multicenter Cohort Study
title_full_unstemmed Fetal Cardiac Hemodynamic and Sonographic Anomalies in Maternal COVID-19 Infection Depending on Vaccination Status—Polish Multicenter Cohort Study
title_short Fetal Cardiac Hemodynamic and Sonographic Anomalies in Maternal COVID-19 Infection Depending on Vaccination Status—Polish Multicenter Cohort Study
title_sort fetal cardiac hemodynamic and sonographic anomalies in maternal covid-19 infection depending on vaccination status—polish multicenter cohort study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10456038/
https://www.ncbi.nlm.nih.gov/pubmed/37629228
http://dx.doi.org/10.3390/jcm12165186
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