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Impact of fatty acid composition on markers of exocrine pancreatic stimulation in dogs

Chronic pancreatitis in dogs is typically managed with a low-fat diet. Human research suggests that consumption of medium-chain triglycerides (MCT) may lessen pancreatic enzyme release compared to consumption of long-chain fatty acids (LCFA). Twelve healthy adult colony dogs were fed a meal of cod a...

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Autores principales: Zhang, Yunyi, Kirk, Claudia A., Tolbert, M. Katherine, Steiner, Jörg M., Donohoe, Dallas, Murphy, Maryanne, Springer, Cary, Witzel-Rollins, Angela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10456140/
https://www.ncbi.nlm.nih.gov/pubmed/37624816
http://dx.doi.org/10.1371/journal.pone.0290555
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author Zhang, Yunyi
Kirk, Claudia A.
Tolbert, M. Katherine
Steiner, Jörg M.
Donohoe, Dallas
Murphy, Maryanne
Springer, Cary
Witzel-Rollins, Angela
author_facet Zhang, Yunyi
Kirk, Claudia A.
Tolbert, M. Katherine
Steiner, Jörg M.
Donohoe, Dallas
Murphy, Maryanne
Springer, Cary
Witzel-Rollins, Angela
author_sort Zhang, Yunyi
collection PubMed
description Chronic pancreatitis in dogs is typically managed with a low-fat diet. Human research suggests that consumption of medium-chain triglycerides (MCT) may lessen pancreatic enzyme release compared to consumption of long-chain fatty acids (LCFA). Twelve healthy adult colony dogs were fed a meal of cod and rice with either 3% metabolizable energy (ME) fat (control), high MCT (25% ME MCT oil, 25% ME butter), high saturated LCFA (50% ME butter), or high unsaturated LCFA (50% ME canola oil) in a 4-period by 4-treatment crossover design. Serum concentrations of canine pancreatic lipase immunoreactivity, gastrin, cholesterol, triglycerides, and serum activities of amylase and DGGR lipase (1,2-o-dilauryl-rac-glycero-3-glutaric acid-(69-methylresorufin) ester lipase) were measured at times 0 (fasted), 30, 120 and 180 minutes post-prandially. Following a 3-or 4-day wash-out period, each dog was assigned a new diet and the process was repeated for all treatments. Data were analyzed as a repeated-measures mixed model ANOVA. Post-hoc pairwise comparisons were run using Tukey-Kramer adjusted p-values. Shapiro-Wilk tests were used to evaluate residual normality. All statistical assumptions were sufficiently met. Statistical significance was defined as P<0.05. Of the markers tested, only serum triglyceride concentrations were affected by treatment, with consumption of high MCT resulting in lower triglycerides than both LCFA groups at times 120 and 180 minutes (P<0.0001). As expected, the high MCT group had higher triglycerides compared to the control group (P<0.0001). The type of dietary fat consumed had little acute impact on most markers of exocrine pancreatic stimulation in healthy dogs.
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spelling pubmed-104561402023-08-26 Impact of fatty acid composition on markers of exocrine pancreatic stimulation in dogs Zhang, Yunyi Kirk, Claudia A. Tolbert, M. Katherine Steiner, Jörg M. Donohoe, Dallas Murphy, Maryanne Springer, Cary Witzel-Rollins, Angela PLoS One Research Article Chronic pancreatitis in dogs is typically managed with a low-fat diet. Human research suggests that consumption of medium-chain triglycerides (MCT) may lessen pancreatic enzyme release compared to consumption of long-chain fatty acids (LCFA). Twelve healthy adult colony dogs were fed a meal of cod and rice with either 3% metabolizable energy (ME) fat (control), high MCT (25% ME MCT oil, 25% ME butter), high saturated LCFA (50% ME butter), or high unsaturated LCFA (50% ME canola oil) in a 4-period by 4-treatment crossover design. Serum concentrations of canine pancreatic lipase immunoreactivity, gastrin, cholesterol, triglycerides, and serum activities of amylase and DGGR lipase (1,2-o-dilauryl-rac-glycero-3-glutaric acid-(69-methylresorufin) ester lipase) were measured at times 0 (fasted), 30, 120 and 180 minutes post-prandially. Following a 3-or 4-day wash-out period, each dog was assigned a new diet and the process was repeated for all treatments. Data were analyzed as a repeated-measures mixed model ANOVA. Post-hoc pairwise comparisons were run using Tukey-Kramer adjusted p-values. Shapiro-Wilk tests were used to evaluate residual normality. All statistical assumptions were sufficiently met. Statistical significance was defined as P<0.05. Of the markers tested, only serum triglyceride concentrations were affected by treatment, with consumption of high MCT resulting in lower triglycerides than both LCFA groups at times 120 and 180 minutes (P<0.0001). As expected, the high MCT group had higher triglycerides compared to the control group (P<0.0001). The type of dietary fat consumed had little acute impact on most markers of exocrine pancreatic stimulation in healthy dogs. Public Library of Science 2023-08-25 /pmc/articles/PMC10456140/ /pubmed/37624816 http://dx.doi.org/10.1371/journal.pone.0290555 Text en © 2023 Zhang et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Zhang, Yunyi
Kirk, Claudia A.
Tolbert, M. Katherine
Steiner, Jörg M.
Donohoe, Dallas
Murphy, Maryanne
Springer, Cary
Witzel-Rollins, Angela
Impact of fatty acid composition on markers of exocrine pancreatic stimulation in dogs
title Impact of fatty acid composition on markers of exocrine pancreatic stimulation in dogs
title_full Impact of fatty acid composition on markers of exocrine pancreatic stimulation in dogs
title_fullStr Impact of fatty acid composition on markers of exocrine pancreatic stimulation in dogs
title_full_unstemmed Impact of fatty acid composition on markers of exocrine pancreatic stimulation in dogs
title_short Impact of fatty acid composition on markers of exocrine pancreatic stimulation in dogs
title_sort impact of fatty acid composition on markers of exocrine pancreatic stimulation in dogs
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10456140/
https://www.ncbi.nlm.nih.gov/pubmed/37624816
http://dx.doi.org/10.1371/journal.pone.0290555
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