Helicase-like transcription factor (Hltf)-deletion activates Hmgb1-Rage axis and granzyme A-mediated killing of pancreatic β cells resulting in neonatal lethality

Epigenetic mechanisms are integral to pancreatic β cell function. Promoter hypermethylation of the helicase like-transcription factor (HLTF) gene—a component of the cellular DNA damage response that contributes to genome stability—has been implicated in age-associated changes in β cells. To study HL...

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Detalles Bibliográficos
Autores principales: Kaur, Gurvinder, Helmer, Rebecca A., Martinez-Marin, Dalia, Sennoune, Souad R., Washburn, Rachel L., Martinez-Zaguilan, Raul, Dufour, Jannette M., Chilton, Beverly S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10456192/
https://www.ncbi.nlm.nih.gov/pubmed/37624843
http://dx.doi.org/10.1371/journal.pone.0286109

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10456192/
https://www.ncbi.nlm.nih.gov/pubmed/37624843
http://dx.doi.org/10.1371/journal.pone.0286109

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