Cargando…

Helicase-like transcription factor (Hltf)-deletion activates Hmgb1-Rage axis and granzyme A-mediated killing of pancreatic β cells resulting in neonatal lethality

Epigenetic mechanisms are integral to pancreatic β cell function. Promoter hypermethylation of the helicase like-transcription factor (HLTF) gene—a component of the cellular DNA damage response that contributes to genome stability—has been implicated in age-associated changes in β cells. To study HL...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kaur, Gurvinder, Helmer, Rebecca A., Martinez-Marin, Dalia, Sennoune, Souad R., Washburn, Rachel L., Martinez-Zaguilan, Raul, Dufour, Jannette M., Chilton, Beverly S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10456192/ https://www.ncbi.nlm.nih.gov/pubmed/37624843 http://dx.doi.org/10.1371/journal.pone.0286109

Ejemplares similares

Helicase-like transcription factor (HLTF)-deleted CDX/TME model of colorectal cancer increased transcription of oxidative phosphorylation genes and diverted glycolysis to boost S-glutathionylation in lymphatic intravascular metastatic niches
por: Martinez-Marin, Dalia, et al.
Publicado: (2023)

Alternative splicing of helicase-like transcription factor (Hltf): Intron retention-dependent activation of immune tolerance at the feto-maternal interface
por: Kaur, Gurvinder, et al.
Publicado: (2018)

SAT-159 Hltf-Deletion Causes Immune Destruction of Pancreatic Beta Cells during Development
por: Kaur, Gurvinder, et al.
Publicado: (2019)

Helicase-like transcription factor-deletion from the tumor microenvironment in a cell line-derived xenograft model of colorectal cancer reprogrammed the human transcriptome-S-nitroso-proteome to promote inflammation and redirect metastasis
por: Helmer, Rebecca A., et al.
Publicado: (2021)

Helicase-Like Transcription Factor (Hltf) Regulates G2/M Transition, Wt1/Gata4/Hif-1a Cardiac Transcription Networks, and Collagen Biogenesis
por: Helmer, Rebecca A., et al.
Publicado: (2013)

Helicase-like transcription factor (Hltf) gene-deletion promotes oxidative phosphorylation (OXPHOS) in colorectal tumors of AOM/DSS-treated mice
por: Helmer, Rebecca A., et al.
Publicado: (2019)

Role of Helicase-Like Transcription Factor (Hltf) in the G2/M Transition and Apoptosis in Brain
por: Helmer, Rebecca A., et al.
Publicado: (2013)

Mouse Sertoli Cells Inhibit Humoral-Based Immunity
por: Washburn, Rachel L., et al.
Publicado: (2022)

Sertoli Cell Immune Regulation: A Double-Edged Sword
por: Washburn, Rachel L., et al.
Publicado: (2022)

Early expression of the Helicase-Like Transcription Factor (HLTF/SMARCA3) in an experimental model of estrogen-induced renal carcinogenesis
por: Debauve, Gaël, et al.
Publicado: (2006)

The Sertoli Cell Complement Signature: A Suspected Mechanism in Xenograft Survival
por: Washburn, Rachel L., et al.
Publicado: (2023)

Loss of HLTF function promotes intestinal carcinogenesis
por: Sandhu, Sumit, et al.
Publicado: (2012)

Cell lines: Valuable tools or useless artifacts
por: Kaur, Gurvinder, et al.
Publicado: (2012)

Granule-mediated Killing: Pathways for Granzyme B–initiated Apoptosis
por: Talanian, Robert V., et al.
Publicado: (1997)

Degradation of helicase-like transcription factor (HLTF) by β-TrCP promotes hepatocarcinogenesis via activation of the p62/mTOR axis
por: Tan, Ye, et al.
Publicado: (2023)

The Immune Tolerance Role of the HMGB1-RAGE Axis
por: Watanabe, Haruki, et al.
Publicado: (2021)

Immunoregulatory Sertoli Cell Allografts Engineered to Express Human Insulin Survive Humoral-Mediated Rejection
por: Washburn, Rachel L., et al.
Publicado: (2022)

Sertoli Cells Express Accommodation, Survival, and Immunoregulatory Factors When Exposed to Normal Human Serum
por: Washburn, Rachel L., et al.
Publicado: (2023)

sRAGE alleviates neutrophilic asthma by blocking HMGB1/RAGE signalling in airway dendritic cells
por: Zhang, Fang, et al.
Publicado: (2017)

An overview of a Sertoli cell transplantation model to study testis morphogenesis and the role of the Sertoli cells in immune privilege
por: Kaur, Gurvinder, et al.
Publicado: (2017)

C-Peptide as a Therapy for Type 1 Diabetes Mellitus
por: Washburn, Rachel L., et al.
Publicado: (2021)

Strand invasion by HLTF as a mechanism for template switch in fork rescue
por: Burkovics, Peter, et al.
Publicado: (2014)

Rad5, HLTF, and SHPRH: A Fresh View of an Old Story
por: Elserafy, Menattallah, et al.
Publicado: (2018)

MAIT cells are licensed through granzyme exchange to kill bacterially sensitized targets
por: Kurioka, A, et al.
Publicado: (2015)

Circulating HMGB1 and RAGE as Clinical Biomarkers in Malignant and Autoimmune Diseases
por: Pilzweger, Christin, et al.
Publicado: (2015)

Molecular signaling of the HMGB1/RAGE axis contributes to cholesteatoma pathogenesis
por: Szczepanski, Miroslaw J., et al.
Publicado: (2014)

Mechanism of HMGB1–RAGE in Kawasaki disease with coronary artery injury
por: Qian, Biying, et al.
Publicado: (2020)

RAGE and HMGB1 Expression in Orbital Tissue Microenvironment in Graves' Ophthalmopathy
por: Łacheta, Dominika, et al.
Publicado: (2021)

Therapeutic Potential of Targeting the HMGB1/RAGE Axis in Inflammatory Diseases
por: Singh, Harbinder, et al.
Publicado: (2022)

Genetically engineered immune privileged Sertoli cells: A new road to cell based gene therapy
por: Kaur, Gurvinder, et al.
Publicado: (2012)

Complementing Testicular Immune Regulation: The Relationship between Sertoli Cells, Complement, and the Immune Response
por: Washburn, Rachel L., et al.
Publicado: (2023)

Opposing Roles of FANCJ and HLTF Protect Forks and Restrain Replication during Stress
por: Peng, Min, et al.
Publicado: (2018)

Helicase-Like Transcription Factor HLTF and E3 Ubiquitin Ligase SHPRH Confer DNA Damage Tolerance through Direct Interactions with Proliferating Cell Nuclear Antigen (PCNA)
por: Seelinger, Mareike, et al.
Publicado: (2020)

Inhibition of HMGB1/RAGE-mediated endocytosis by HMGB1 antagonist box A, anti-HMGB1 antibodies, and cholinergic agonists suppresses inflammation
por: Yang, Huan, et al.
Publicado: (2019)

Pit cells exclusively kill P815 tumor cells by the perforin/granzyme pathway
por: Vermijlen, David, et al.
Publicado: (2004)

The HMGB1-RAGE axis modulates the growth of autophagy-deficient hepatic tumors
por: Khambu, Bilon, et al.
Publicado: (2020)

Extracellular HMGB1 interacts with RAGE and promotes chemoresistance in acute leukemia cells
por: Lai, Weixin, et al.
Publicado: (2021)

HIV-1 Vpr counteracts HLTF-mediated restriction of HIV-1 infection in T cells
por: Yan, Junpeng, et al.
Publicado: (2019)

Rad5 and Its Human Homologs, HLTF and SHPRH, Are Novel Interactors of Mismatch Repair
por: Miller, Anna K., et al.
Publicado: (2022)

Soluble RAGE attenuates AngII-induced endothelial hyperpermeability by disrupting HMGB1-mediated crosstalk between AT1R and RAGE
por: Jeong, Jisu, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_iovmv4k45epvbmfdsctc60l2ai