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Trichoderols B-G, Six New Lipids from the Marine Algicolous Fungus Trichoderma sp. Z43
Six new lipids, trichoderols B-G (1–6), along with a known one, triharzianin B (7), were isolated from the culture of Trichoderma sp. Z43 obtained from the surface of the marine brown alga Dictyopteris divaricata. Their structures and relative configurations were identified by interpretation of 1D/2...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10456296/ https://www.ncbi.nlm.nih.gov/pubmed/37623734 http://dx.doi.org/10.3390/md21080453 |
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author | Shi, Zhen-Zhen Yin, Xiu-Li Ji, Nai-Yun |
author_facet | Shi, Zhen-Zhen Yin, Xiu-Li Ji, Nai-Yun |
author_sort | Shi, Zhen-Zhen |
collection | PubMed |
description | Six new lipids, trichoderols B-G (1–6), along with a known one, triharzianin B (7), were isolated from the culture of Trichoderma sp. Z43 obtained from the surface of the marine brown alga Dictyopteris divaricata. Their structures and relative configurations were identified by interpretation of 1D/2D NMR and MS data. Compounds 1–7 were assayed for inhibiting the growth of three phytopathogenic fungi (Fusarium graminearum, Gaeumannomyces graminis, and Glomerella cingulata), four marine phytoplankton species (Amphidinium carterae, Heterocapsa circularisquama, Heterosigma akashiwo, and Prorocentrum donghaiense), and one marine zooplankton (Artemia salina). Compounds 1, 4, and 7 exhibited weak antifungal activities against three phytopathogenic fungi tested with MIC ≥ 64 μg/mL. All compounds displayed moderate antimicroalgal activity with IC(50) ≥ 15 μg/mL and low toxicity to the brine shrimp Artemia salina. |
format | Online Article Text |
id | pubmed-10456296 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-104562962023-08-26 Trichoderols B-G, Six New Lipids from the Marine Algicolous Fungus Trichoderma sp. Z43 Shi, Zhen-Zhen Yin, Xiu-Li Ji, Nai-Yun Mar Drugs Article Six new lipids, trichoderols B-G (1–6), along with a known one, triharzianin B (7), were isolated from the culture of Trichoderma sp. Z43 obtained from the surface of the marine brown alga Dictyopteris divaricata. Their structures and relative configurations were identified by interpretation of 1D/2D NMR and MS data. Compounds 1–7 were assayed for inhibiting the growth of three phytopathogenic fungi (Fusarium graminearum, Gaeumannomyces graminis, and Glomerella cingulata), four marine phytoplankton species (Amphidinium carterae, Heterocapsa circularisquama, Heterosigma akashiwo, and Prorocentrum donghaiense), and one marine zooplankton (Artemia salina). Compounds 1, 4, and 7 exhibited weak antifungal activities against three phytopathogenic fungi tested with MIC ≥ 64 μg/mL. All compounds displayed moderate antimicroalgal activity with IC(50) ≥ 15 μg/mL and low toxicity to the brine shrimp Artemia salina. MDPI 2023-08-17 /pmc/articles/PMC10456296/ /pubmed/37623734 http://dx.doi.org/10.3390/md21080453 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Shi, Zhen-Zhen Yin, Xiu-Li Ji, Nai-Yun Trichoderols B-G, Six New Lipids from the Marine Algicolous Fungus Trichoderma sp. Z43 |
title | Trichoderols B-G, Six New Lipids from the Marine Algicolous Fungus Trichoderma sp. Z43 |
title_full | Trichoderols B-G, Six New Lipids from the Marine Algicolous Fungus Trichoderma sp. Z43 |
title_fullStr | Trichoderols B-G, Six New Lipids from the Marine Algicolous Fungus Trichoderma sp. Z43 |
title_full_unstemmed | Trichoderols B-G, Six New Lipids from the Marine Algicolous Fungus Trichoderma sp. Z43 |
title_short | Trichoderols B-G, Six New Lipids from the Marine Algicolous Fungus Trichoderma sp. Z43 |
title_sort | trichoderols b-g, six new lipids from the marine algicolous fungus trichoderma sp. z43 |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10456296/ https://www.ncbi.nlm.nih.gov/pubmed/37623734 http://dx.doi.org/10.3390/md21080453 |
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