Cargando…

Nuclear PTEN Regulates Thymidylate Biosynthesis in Human Prostate Cancer Cell Lines

The phosphatase and tensin homologue deleted on chromosome 10 (PTEN) tumor suppressor governs a variety of biological processes, including metabolism, by acting on distinct molecular targets in different subcellular compartments. In the cytosol, inactive PTEN can be recruited to the plasma membrane...

Descripción completa

Detalles Bibliográficos
Autores principales:	Loh, Zoe N., Wang, Mu-En, Wan, Changxin, Asara, John M., Ji, Zhicheng, Chen, Ming
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10456368/ https://www.ncbi.nlm.nih.gov/pubmed/37623882 http://dx.doi.org/10.3390/metabo13080939

Ejemplares similares

SHMT1 and SHMT2 Are Functionally Redundant in Nuclear De novo Thymidylate Biosynthesis
por: Anderson, Donald D., et al.
Publicado: (2009)

An unusual mechanism of thymidylate biosynthesis in organisms containing the thyX Gene
por: Koehn, Eric M., et al.
Publicado: (2009)

The contribution of mitochondrial thymidylate synthesis in preventing the nuclear genome stress
por: Lee, Ming-Hsiang, et al.
Publicado: (2014)

Genetic Variants in the Mitochondrial Thymidylate Biosynthesis Pathway Increase Colorectal Cancer Risk
por: Arrait, Entesar M., et al.
Publicado: (2023)

Contribution of Cytidine Deaminase to Thymidylate Biosynthesis in Trypanosoma brucei: Intracellular Localization and Properties of the Enzyme
por: Moro-Bulnes, Ana, et al.
Publicado: (2019)

Integrating multiple single-cell multi-omics samples with Smmit
por: Wan, Changxin, et al.
Publicado: (2023)

Effect of Hammerhead Ribozyme against Human Thymidylate Synthase on the Cytotoxicity of Thymidylate Synthase Inhibitors
por: Kobayashi, Hiroyuki, et al.
Publicado: (1995)

The PTEN Conundrum: How to Target PTEN-Deficient Prostate Cancer
por: Turnham, Daniel J., et al.
Publicado: (2020)

Down regulation by a low-zinc diet in gene expression of rat prostatic thymidylate synthase and thymidine kinase
por: Ishikawa, Yuko, et al.
Publicado: (2008)

FBXO22 degrades nuclear PTEN to promote tumorigenesis
por: Ge, Meng-Kai, et al.
Publicado: (2020)

Pten Regulates Epithelial Cytodifferentiation during Prostate Development
por: Lokody, Isabel B., et al.
Publicado: (2015)

Structural basis of the substrate preference towards CMP for a thymidylate synthase MilA involved in mildiomycin biosynthesis
por: Zhao, Gong, et al.
Publicado: (2016)

SENP1 regulates PTEN stability to dictate prostate cancer development
por: Bawa-Khalfe, Tasneem, et al.
Publicado: (2016)

Orphan nuclear receptors as regulators of intratumoral androgen biosynthesis in castration-resistant prostate cancer
por: Zhou, Jianfu, et al.
Publicado: (2021)

Substrate Activation in Flavin-Dependent Thymidylate Synthase
por: Mishanina, Tatiana V., et al.
Publicado: (2014)

Trichinella pseudospiralis vs. T. spiralis thymidylate synthase gene structure and T. pseudospiralis thymidylate synthase retrogene sequence
por: Jagielska, Elżbieta, et al.
Publicado: (2014)

Nuclear thymidylate synthase expression, p53 expression and 5FU response in colorectal carcinoma
por: Wong, N A C S, et al.
Publicado: (2001)

Conservation and Role of Electrostatics in Thymidylate Synthase
por: Garg, Divita, et al.
Publicado: (2015)

Myosin 1b Regulates Nuclear AKT Activation by Preventing Localization of PTEN in the Nucleus
por: Yu, Yi, et al.
Publicado: (2019)

Characterization of the bipartite degron that regulates ubiquitin-independent degradation of thymidylate synthase
por: Barbour, Karen W., et al.
Publicado: (2013)

Differential expression of enzymes in thymidylate biosynthesis in zebrafish at different developmental stages: implications for dtymk mutation-caused neurodegenerative disorders
por: Frisk, Junmei Hu, et al.
Publicado: (2022)

Reactivating nuclear PTEN to treat CLL
por: Bernardi, Rosa, et al.
Publicado: (2017)

Resveratrol regulates the PTEN/AKT pathway through androgen receptor-dependent and -independent mechanisms in prostate cancer cell lines
por: Wang, Yu, et al.
Publicado: (2010)

Expression Levels of Thymidylate Synthase, Thymidylate Phosphorylase and Dihydropyrimidine Dehydrogenase in Head and Neck Squamous Cell Carcinoma: Preliminary Study
por: Aubry, K., et al.
Publicado: (2008)

Structure of thymidylate kinase from Ehrlichia chaffeensis
por: Leibly, David J., et al.
Publicado: (2011)

Concerted versus Stepwise Mechanism in Thymidylate Synthase
por: Islam, Zahidul, et al.
Publicado: (2014)

Antitumor Activity of Fluoropyrimidines and Thymidylate Synthetase Inhibition
por: Kubota, Tetsuro, et al.
Publicado: (1991)

Overexpression of thymidylate synthase (TYMS) is associated with aggressive tumor features and early PSA recurrence in prostate cancer
por: Burdelski, Christoph, et al.
Publicado: (2015)

LZTS2 and PTEN collaboratively regulate ß-catenin in prostatic tumorigenesis
por: Yu, Eun-Jeong, et al.
Publicado: (2017)

Oncogenic microRNA-4534 regulates PTEN pathway in prostate cancer
por: Nip, Hannah, et al.
Publicado: (2016)

BAG5 regulates PTEN stability in MCF-7 cell line
por: Ying, Zhang, et al.
Publicado: (2013)

Genomic Rearrangements of PTEN in Prostate Cancer
por: Phin, Sopheap, et al.
Publicado: (2013)

AKT activation because of PTEN loss upregulates xCT via GSK3β/NRF2, leading to inhibition of ferroptosis in PTEN-mutant tumor cells
por: Cahuzac, Kaitlyn M., et al.
Publicado: (2023)

PTEN loss detection in prostate cancer: comparison of PTEN immunohistochemistry and PTEN FISH in a large retrospective prostatectomy cohort
por: Lotan, Tamara L., et al.
Publicado: (2017)

Molecular characterisation of two cell lines selected for resistance to the folate-based thymidylate synthase inhibitor, ZD1694.
por: Freemantle, S. J., et al.
Publicado: (1995)

The relationship between intrinsic thymidylate synthase expression and sensitivity to THYMITAQ in human leukaemia and colorectal carcinoma cell lines.
por: Estlin, E. J., et al.
Publicado: (1997)

The Long and the Short of PTEN in the Regulation of Mitophagy
por: Wang, Liming, et al.
Publicado: (2020)

Expression of thymidylate synthase and orotate phosphoribosyltransferase in thymic carcinoma
por: YOKOTA, KEISUKE, et al.
Publicado: (2012)

Analysis of mRNA recognition by human thymidylate synthase
por: Brunn, Nicholas D., et al.
Publicado: (2014)

Bacterial versus human thymidylate synthase: Kinetics and functionality
por: Islam, Zahidul, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_3j248bmrtvlhaupi8248bcsvqp