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Mixed Eccrine Cutaneous Tumor with Folliculo–Sebaceous Differentiation: Case Report and Literature Review
Background/Introduction: Cutaneous mixed tumor is a rare benign neoplasm that exhibits a wide range of metaplastic changes and differentiation in the epithelial, myoepithelial, and stromal components, which is often confused with various other skin lesions. Case report: We present an unusual case of...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10456404/ https://www.ncbi.nlm.nih.gov/pubmed/37629755 http://dx.doi.org/10.3390/medicina59081465 |
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author | Kisova, Dimitrinka Dikov, Tihomir Ivanova, Vesela Stoyanov, Hristo Yordanova, Greta |
author_facet | Kisova, Dimitrinka Dikov, Tihomir Ivanova, Vesela Stoyanov, Hristo Yordanova, Greta |
author_sort | Kisova, Dimitrinka |
collection | PubMed |
description | Background/Introduction: Cutaneous mixed tumor is a rare benign neoplasm that exhibits a wide range of metaplastic changes and differentiation in the epithelial, myoepithelial, and stromal components, which is often confused with various other skin lesions. Case report: We present an unusual case of a 58-year-old woman with a mixed tumor of the upper lip, previously misdiagnosed as adnexal carcinoma on a preoperative biopsy. The excision biopsy shows a well-circumscribed lesion composed of various cells and structures featuring folliculo–sebaceous differentiation embedded in a prominent chondromyxoid stroma. The immunohistochemical study proves the various lineages of differentiation and classifies the neoplasm as the less common eccrine subtype of cutaneous mixed tumor. Discussion: The common embryologic origin of the folliculo–sebaceous apocrine complex leads to a great histological variety of cellular components of mixed tumors and the formation of structures that resemble established types of adnexal neoplasms, which could be a diagnostic pitfall, especially on a small incision biopsy. |
format | Online Article Text |
id | pubmed-10456404 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-104564042023-08-26 Mixed Eccrine Cutaneous Tumor with Folliculo–Sebaceous Differentiation: Case Report and Literature Review Kisova, Dimitrinka Dikov, Tihomir Ivanova, Vesela Stoyanov, Hristo Yordanova, Greta Medicina (Kaunas) Case Report Background/Introduction: Cutaneous mixed tumor is a rare benign neoplasm that exhibits a wide range of metaplastic changes and differentiation in the epithelial, myoepithelial, and stromal components, which is often confused with various other skin lesions. Case report: We present an unusual case of a 58-year-old woman with a mixed tumor of the upper lip, previously misdiagnosed as adnexal carcinoma on a preoperative biopsy. The excision biopsy shows a well-circumscribed lesion composed of various cells and structures featuring folliculo–sebaceous differentiation embedded in a prominent chondromyxoid stroma. The immunohistochemical study proves the various lineages of differentiation and classifies the neoplasm as the less common eccrine subtype of cutaneous mixed tumor. Discussion: The common embryologic origin of the folliculo–sebaceous apocrine complex leads to a great histological variety of cellular components of mixed tumors and the formation of structures that resemble established types of adnexal neoplasms, which could be a diagnostic pitfall, especially on a small incision biopsy. MDPI 2023-08-16 /pmc/articles/PMC10456404/ /pubmed/37629755 http://dx.doi.org/10.3390/medicina59081465 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Case Report Kisova, Dimitrinka Dikov, Tihomir Ivanova, Vesela Stoyanov, Hristo Yordanova, Greta Mixed Eccrine Cutaneous Tumor with Folliculo–Sebaceous Differentiation: Case Report and Literature Review |
title | Mixed Eccrine Cutaneous Tumor with Folliculo–Sebaceous Differentiation: Case Report and Literature Review |
title_full | Mixed Eccrine Cutaneous Tumor with Folliculo–Sebaceous Differentiation: Case Report and Literature Review |
title_fullStr | Mixed Eccrine Cutaneous Tumor with Folliculo–Sebaceous Differentiation: Case Report and Literature Review |
title_full_unstemmed | Mixed Eccrine Cutaneous Tumor with Folliculo–Sebaceous Differentiation: Case Report and Literature Review |
title_short | Mixed Eccrine Cutaneous Tumor with Folliculo–Sebaceous Differentiation: Case Report and Literature Review |
title_sort | mixed eccrine cutaneous tumor with folliculo–sebaceous differentiation: case report and literature review |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10456404/ https://www.ncbi.nlm.nih.gov/pubmed/37629755 http://dx.doi.org/10.3390/medicina59081465 |
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