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Granulomatous Mastitis Occurring during Pregnancy: A Case Report

Background and Objectives: Granulomatous mastitis is a benign disease with a clinical presentation similar to that of breast cancer, and is most commonly observed in women of childbearing age. Although it has been suggested that autoimmune diseases are involved in its pathogenesis, no specific treat...

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Autores principales: Yoshino, Ryusei, Yoshida, Nana, Ito, Akane, Ujiie, Nanami, Nakatsubo, Masaki, Hayashi, Manami, Kitada, Masahiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10456481/
https://www.ncbi.nlm.nih.gov/pubmed/37629708
http://dx.doi.org/10.3390/medicina59081418
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author Yoshino, Ryusei
Yoshida, Nana
Ito, Akane
Ujiie, Nanami
Nakatsubo, Masaki
Hayashi, Manami
Kitada, Masahiro
author_facet Yoshino, Ryusei
Yoshida, Nana
Ito, Akane
Ujiie, Nanami
Nakatsubo, Masaki
Hayashi, Manami
Kitada, Masahiro
author_sort Yoshino, Ryusei
collection PubMed
description Background and Objectives: Granulomatous mastitis is a benign disease with a clinical presentation similar to that of breast cancer, and is most commonly observed in women of childbearing age. Although it has been suggested that autoimmune diseases are involved in its pathogenesis, no specific treatments have been established. The occurrence of this disease during pregnancy has rarely been reported. We presented the case of a 37-year-old woman who complained of left breast induration at 24 weeks’ gestation. Materials and Methods: She was pregnant and manifested a dichorionic, diamniotic placenta. At 24 weeks of gestation, the patient experienced a sensation of hardness in her left breast. Mastitis was suspected, and she was treated with cephem antibiotics. Simultaneously, she was diagnosed with erythema nodosum in the extremities. As her symptoms did not improve, an incisional drainage was performed. Bacterial cultures were obtained at 31 weeks of gestation, and Corynebacterium kroppenstedtii was detected. Results: An elective cesarean section was performed at 37 weeks of gestation, and the baby was delivered safely. After delivery, a needle biopsy was performed, and the patient was diagnosed with granulomatous mastitis. She was completely cured with prednisolone after weaning. In this case, the patient’s condition was maintained through incision and drainage, as well as antibiotic, anti-inflammatory, and analgesic drugs during pregnancy. This approach was chosen, taking into consideration the potential side effects of steroids. Conclusions: This case suggests that incisional drainage and antibiotic therapy, as well as steroids and surgery, may be considered in the treatment of granulomatous mastitis occurring during pregnancy. This may also be true for management during delivery. After delivery, breastfeeding and steroidal therapy proved to be effective in treating the condition.
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spelling pubmed-104564812023-08-26 Granulomatous Mastitis Occurring during Pregnancy: A Case Report Yoshino, Ryusei Yoshida, Nana Ito, Akane Ujiie, Nanami Nakatsubo, Masaki Hayashi, Manami Kitada, Masahiro Medicina (Kaunas) Case Report Background and Objectives: Granulomatous mastitis is a benign disease with a clinical presentation similar to that of breast cancer, and is most commonly observed in women of childbearing age. Although it has been suggested that autoimmune diseases are involved in its pathogenesis, no specific treatments have been established. The occurrence of this disease during pregnancy has rarely been reported. We presented the case of a 37-year-old woman who complained of left breast induration at 24 weeks’ gestation. Materials and Methods: She was pregnant and manifested a dichorionic, diamniotic placenta. At 24 weeks of gestation, the patient experienced a sensation of hardness in her left breast. Mastitis was suspected, and she was treated with cephem antibiotics. Simultaneously, she was diagnosed with erythema nodosum in the extremities. As her symptoms did not improve, an incisional drainage was performed. Bacterial cultures were obtained at 31 weeks of gestation, and Corynebacterium kroppenstedtii was detected. Results: An elective cesarean section was performed at 37 weeks of gestation, and the baby was delivered safely. After delivery, a needle biopsy was performed, and the patient was diagnosed with granulomatous mastitis. She was completely cured with prednisolone after weaning. In this case, the patient’s condition was maintained through incision and drainage, as well as antibiotic, anti-inflammatory, and analgesic drugs during pregnancy. This approach was chosen, taking into consideration the potential side effects of steroids. Conclusions: This case suggests that incisional drainage and antibiotic therapy, as well as steroids and surgery, may be considered in the treatment of granulomatous mastitis occurring during pregnancy. This may also be true for management during delivery. After delivery, breastfeeding and steroidal therapy proved to be effective in treating the condition. MDPI 2023-08-03 /pmc/articles/PMC10456481/ /pubmed/37629708 http://dx.doi.org/10.3390/medicina59081418 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Yoshino, Ryusei
Yoshida, Nana
Ito, Akane
Ujiie, Nanami
Nakatsubo, Masaki
Hayashi, Manami
Kitada, Masahiro
Granulomatous Mastitis Occurring during Pregnancy: A Case Report
title Granulomatous Mastitis Occurring during Pregnancy: A Case Report
title_full Granulomatous Mastitis Occurring during Pregnancy: A Case Report
title_fullStr Granulomatous Mastitis Occurring during Pregnancy: A Case Report
title_full_unstemmed Granulomatous Mastitis Occurring during Pregnancy: A Case Report
title_short Granulomatous Mastitis Occurring during Pregnancy: A Case Report
title_sort granulomatous mastitis occurring during pregnancy: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10456481/
https://www.ncbi.nlm.nih.gov/pubmed/37629708
http://dx.doi.org/10.3390/medicina59081418
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