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Can Routine Laboratory Tests Be Suggestive in Determining Suspicions of Malignancy in the Case of Thyroid Nodules?
Background and objectives: Thyroid nodules are a common finding in clinical practice and can be either benign or malignant. The aim of this study was to compare laboratory parameters between patients with malignant thyroid nodules and those with benign thyroid nodules. Materials and methods: A total...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10456539/ https://www.ncbi.nlm.nih.gov/pubmed/37629778 http://dx.doi.org/10.3390/medicina59081488 |
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author | Matei, Mervat Vlad, Mihaela Maria Golu, Ioana Dumitru, Cristina Ștefania De Scisciolo, Graziano Matei, Sergiu-Ciprian |
author_facet | Matei, Mervat Vlad, Mihaela Maria Golu, Ioana Dumitru, Cristina Ștefania De Scisciolo, Graziano Matei, Sergiu-Ciprian |
author_sort | Matei, Mervat |
collection | PubMed |
description | Background and objectives: Thyroid nodules are a common finding in clinical practice and can be either benign or malignant. The aim of this study was to compare laboratory parameters between patients with malignant thyroid nodules and those with benign thyroid nodules. Materials and methods: A total of 845 patients were included, with 251 in the study group (malignant thyroid nodules) and 594 in the control group (benign thyroid nodules). Results: Our results show that there were statistically significant differences in several laboratory parameters, including FT3, FT4, ESR, fibrinogen, WBC, and lymphocyte percentage, between the two patient groups (p < 0.05). Conclusions: These findings suggest that certain laboratory parameters may be useful in differentiating between benign and malignant thyroid nodules and could aid in the diagnosis and treatment of thyroid cancer. However, further diagnostic tests such as fine-needle aspiration biopsy and imaging studies are typically required for an accurate diagnosis. Routine laboratory tests prove most effective when combined with other diagnostic methods to identify thyroid cancer. Although not conclusive on their own, these tests significantly suggest and guide physicians to suspect malignancy in thyroid nodules. This affirmative answer to our question, “Can routine laboratory tests be suggestive in determining suspicions of malignancy in the case of thyroid nodules?” aligns with the results of our study. |
format | Online Article Text |
id | pubmed-10456539 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-104565392023-08-26 Can Routine Laboratory Tests Be Suggestive in Determining Suspicions of Malignancy in the Case of Thyroid Nodules? Matei, Mervat Vlad, Mihaela Maria Golu, Ioana Dumitru, Cristina Ștefania De Scisciolo, Graziano Matei, Sergiu-Ciprian Medicina (Kaunas) Article Background and objectives: Thyroid nodules are a common finding in clinical practice and can be either benign or malignant. The aim of this study was to compare laboratory parameters between patients with malignant thyroid nodules and those with benign thyroid nodules. Materials and methods: A total of 845 patients were included, with 251 in the study group (malignant thyroid nodules) and 594 in the control group (benign thyroid nodules). Results: Our results show that there were statistically significant differences in several laboratory parameters, including FT3, FT4, ESR, fibrinogen, WBC, and lymphocyte percentage, between the two patient groups (p < 0.05). Conclusions: These findings suggest that certain laboratory parameters may be useful in differentiating between benign and malignant thyroid nodules and could aid in the diagnosis and treatment of thyroid cancer. However, further diagnostic tests such as fine-needle aspiration biopsy and imaging studies are typically required for an accurate diagnosis. Routine laboratory tests prove most effective when combined with other diagnostic methods to identify thyroid cancer. Although not conclusive on their own, these tests significantly suggest and guide physicians to suspect malignancy in thyroid nodules. This affirmative answer to our question, “Can routine laboratory tests be suggestive in determining suspicions of malignancy in the case of thyroid nodules?” aligns with the results of our study. MDPI 2023-08-18 /pmc/articles/PMC10456539/ /pubmed/37629778 http://dx.doi.org/10.3390/medicina59081488 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Matei, Mervat Vlad, Mihaela Maria Golu, Ioana Dumitru, Cristina Ștefania De Scisciolo, Graziano Matei, Sergiu-Ciprian Can Routine Laboratory Tests Be Suggestive in Determining Suspicions of Malignancy in the Case of Thyroid Nodules? |
title | Can Routine Laboratory Tests Be Suggestive in Determining Suspicions of Malignancy in the Case of Thyroid Nodules? |
title_full | Can Routine Laboratory Tests Be Suggestive in Determining Suspicions of Malignancy in the Case of Thyroid Nodules? |
title_fullStr | Can Routine Laboratory Tests Be Suggestive in Determining Suspicions of Malignancy in the Case of Thyroid Nodules? |
title_full_unstemmed | Can Routine Laboratory Tests Be Suggestive in Determining Suspicions of Malignancy in the Case of Thyroid Nodules? |
title_short | Can Routine Laboratory Tests Be Suggestive in Determining Suspicions of Malignancy in the Case of Thyroid Nodules? |
title_sort | can routine laboratory tests be suggestive in determining suspicions of malignancy in the case of thyroid nodules? |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10456539/ https://www.ncbi.nlm.nih.gov/pubmed/37629778 http://dx.doi.org/10.3390/medicina59081488 |
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