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Autoimmune Heart Disease: A Comprehensive Summary for Forensic Practice

Autoimmune heart disease is a non-random condition characterised by immune system-mediated aggression against cardiac tissue. Cardiac changes often exhibit nonspecific features and, if unrecognised, can result in fatal outcomes even among seemingly healthy young individuals. In the absence of reliab...

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Autores principales: Mezzetti, Eleonora, Costantino, Andrea, Leoni, Matteo, Pieretti, Rebecca, Di Paolo, Marco, Frati, Paola, Maiese, Aniello, Fineschi, Vittorio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10456745/
https://www.ncbi.nlm.nih.gov/pubmed/37629654
http://dx.doi.org/10.3390/medicina59081364
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author Mezzetti, Eleonora
Costantino, Andrea
Leoni, Matteo
Pieretti, Rebecca
Di Paolo, Marco
Frati, Paola
Maiese, Aniello
Fineschi, Vittorio
author_facet Mezzetti, Eleonora
Costantino, Andrea
Leoni, Matteo
Pieretti, Rebecca
Di Paolo, Marco
Frati, Paola
Maiese, Aniello
Fineschi, Vittorio
author_sort Mezzetti, Eleonora
collection PubMed
description Autoimmune heart disease is a non-random condition characterised by immune system-mediated aggression against cardiac tissue. Cardiac changes often exhibit nonspecific features and, if unrecognised, can result in fatal outcomes even among seemingly healthy young individuals. In the absence of reliable medical history, the primary challenge lies in differentiating between the various cardiopathies. Numerous immunohistochemical and genetic studies have endeavoured to characterise distinct types of cardiopathies, facilitating their differentiation during autopsy examinations. However, the presence of a standardised protocol that forensic pathologists can employ to guide their investigations would be beneficial. Hence, this summary aims to present the spectrum of autoimmune cardiopathies, including emerging insights such as SARS-CoV-2-induced cardiopathies, and proposes the utilisation of practical tools, such as blood markers, to aid forensic pathologists in their routine practice.
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spelling pubmed-104567452023-08-26 Autoimmune Heart Disease: A Comprehensive Summary for Forensic Practice Mezzetti, Eleonora Costantino, Andrea Leoni, Matteo Pieretti, Rebecca Di Paolo, Marco Frati, Paola Maiese, Aniello Fineschi, Vittorio Medicina (Kaunas) Review Autoimmune heart disease is a non-random condition characterised by immune system-mediated aggression against cardiac tissue. Cardiac changes often exhibit nonspecific features and, if unrecognised, can result in fatal outcomes even among seemingly healthy young individuals. In the absence of reliable medical history, the primary challenge lies in differentiating between the various cardiopathies. Numerous immunohistochemical and genetic studies have endeavoured to characterise distinct types of cardiopathies, facilitating their differentiation during autopsy examinations. However, the presence of a standardised protocol that forensic pathologists can employ to guide their investigations would be beneficial. Hence, this summary aims to present the spectrum of autoimmune cardiopathies, including emerging insights such as SARS-CoV-2-induced cardiopathies, and proposes the utilisation of practical tools, such as blood markers, to aid forensic pathologists in their routine practice. MDPI 2023-07-25 /pmc/articles/PMC10456745/ /pubmed/37629654 http://dx.doi.org/10.3390/medicina59081364 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Mezzetti, Eleonora
Costantino, Andrea
Leoni, Matteo
Pieretti, Rebecca
Di Paolo, Marco
Frati, Paola
Maiese, Aniello
Fineschi, Vittorio
Autoimmune Heart Disease: A Comprehensive Summary for Forensic Practice
title Autoimmune Heart Disease: A Comprehensive Summary for Forensic Practice
title_full Autoimmune Heart Disease: A Comprehensive Summary for Forensic Practice
title_fullStr Autoimmune Heart Disease: A Comprehensive Summary for Forensic Practice
title_full_unstemmed Autoimmune Heart Disease: A Comprehensive Summary for Forensic Practice
title_short Autoimmune Heart Disease: A Comprehensive Summary for Forensic Practice
title_sort autoimmune heart disease: a comprehensive summary for forensic practice
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10456745/
https://www.ncbi.nlm.nih.gov/pubmed/37629654
http://dx.doi.org/10.3390/medicina59081364
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