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Plasma Amino Acids in NAFLD Patients with Obesity Are Associated with Steatosis and Fibrosis: Results from the MAST4HEALTH Study
Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) have been linked to changes in amino acid (AA) levels. The objective of the current study was to examine the relationship between MRI parameters that reflect inflammation and fibrosis and plasma AA concentrations in N...
Autores principales: | , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10456787/ https://www.ncbi.nlm.nih.gov/pubmed/37623902 http://dx.doi.org/10.3390/metabo13080959 |
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author | Amanatidou, Athina I. Mikropoulou, Eleni V. Amerikanou, Charalampia Milanovic, Maja Stojanoski, Stefan Bjelan, Mladen Cesarini, Lucia Campolo, Jonica Thanopoulou, Anastasia Banerjee, Rajarshi Kurth, Mary Jo Milic, Natasa Medic-Stojanoska, Milica Trivella, Maria Giovanna Visvikis-Siest, Sophie Gastaldelli, Amalia Halabalaki, Maria Kaliora, Andriana C. Dedoussis, George V. |
author_facet | Amanatidou, Athina I. Mikropoulou, Eleni V. Amerikanou, Charalampia Milanovic, Maja Stojanoski, Stefan Bjelan, Mladen Cesarini, Lucia Campolo, Jonica Thanopoulou, Anastasia Banerjee, Rajarshi Kurth, Mary Jo Milic, Natasa Medic-Stojanoska, Milica Trivella, Maria Giovanna Visvikis-Siest, Sophie Gastaldelli, Amalia Halabalaki, Maria Kaliora, Andriana C. Dedoussis, George V. |
author_sort | Amanatidou, Athina I. |
collection | PubMed |
description | Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) have been linked to changes in amino acid (AA) levels. The objective of the current study was to examine the relationship between MRI parameters that reflect inflammation and fibrosis and plasma AA concentrations in NAFLD patients. Plasma AA levels of 97 NAFLD patients from the MAST4HEALTH study were quantified with liquid chromatography. Medical, anthropometric and lifestyle characteristics were collected and biochemical parameters, as well as inflammatory and oxidative stress biomarkers, were measured. In total, subjects with a higher MRI-proton density fat fraction (MRI-PDFF) exhibited higher plasma AA levels compared to subjects with lower PDFF. The concentrations of BCAAs (p-Value: 0.03), AAAs (p-Value: 0.039), L-valine (p-Value: 0.029), L-tyrosine (p-Value: 0.039) and L-isoleucine (p-Value: 0.032) were found to be significantly higher in the higher PDFF group compared to lower group. Plasma AA levels varied according to MRI-PDFF. Significant associations were also demonstrated between AAs and MRI-PDFF and MRI-cT1, showing the potential utility of circulating AAs as diagnostic markers of NAFLD. |
format | Online Article Text |
id | pubmed-10456787 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-104567872023-08-26 Plasma Amino Acids in NAFLD Patients with Obesity Are Associated with Steatosis and Fibrosis: Results from the MAST4HEALTH Study Amanatidou, Athina I. Mikropoulou, Eleni V. Amerikanou, Charalampia Milanovic, Maja Stojanoski, Stefan Bjelan, Mladen Cesarini, Lucia Campolo, Jonica Thanopoulou, Anastasia Banerjee, Rajarshi Kurth, Mary Jo Milic, Natasa Medic-Stojanoska, Milica Trivella, Maria Giovanna Visvikis-Siest, Sophie Gastaldelli, Amalia Halabalaki, Maria Kaliora, Andriana C. Dedoussis, George V. Metabolites Article Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) have been linked to changes in amino acid (AA) levels. The objective of the current study was to examine the relationship between MRI parameters that reflect inflammation and fibrosis and plasma AA concentrations in NAFLD patients. Plasma AA levels of 97 NAFLD patients from the MAST4HEALTH study were quantified with liquid chromatography. Medical, anthropometric and lifestyle characteristics were collected and biochemical parameters, as well as inflammatory and oxidative stress biomarkers, were measured. In total, subjects with a higher MRI-proton density fat fraction (MRI-PDFF) exhibited higher plasma AA levels compared to subjects with lower PDFF. The concentrations of BCAAs (p-Value: 0.03), AAAs (p-Value: 0.039), L-valine (p-Value: 0.029), L-tyrosine (p-Value: 0.039) and L-isoleucine (p-Value: 0.032) were found to be significantly higher in the higher PDFF group compared to lower group. Plasma AA levels varied according to MRI-PDFF. Significant associations were also demonstrated between AAs and MRI-PDFF and MRI-cT1, showing the potential utility of circulating AAs as diagnostic markers of NAFLD. MDPI 2023-08-18 /pmc/articles/PMC10456787/ /pubmed/37623902 http://dx.doi.org/10.3390/metabo13080959 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Amanatidou, Athina I. Mikropoulou, Eleni V. Amerikanou, Charalampia Milanovic, Maja Stojanoski, Stefan Bjelan, Mladen Cesarini, Lucia Campolo, Jonica Thanopoulou, Anastasia Banerjee, Rajarshi Kurth, Mary Jo Milic, Natasa Medic-Stojanoska, Milica Trivella, Maria Giovanna Visvikis-Siest, Sophie Gastaldelli, Amalia Halabalaki, Maria Kaliora, Andriana C. Dedoussis, George V. Plasma Amino Acids in NAFLD Patients with Obesity Are Associated with Steatosis and Fibrosis: Results from the MAST4HEALTH Study |
title | Plasma Amino Acids in NAFLD Patients with Obesity Are Associated with Steatosis and Fibrosis: Results from the MAST4HEALTH Study |
title_full | Plasma Amino Acids in NAFLD Patients with Obesity Are Associated with Steatosis and Fibrosis: Results from the MAST4HEALTH Study |
title_fullStr | Plasma Amino Acids in NAFLD Patients with Obesity Are Associated with Steatosis and Fibrosis: Results from the MAST4HEALTH Study |
title_full_unstemmed | Plasma Amino Acids in NAFLD Patients with Obesity Are Associated with Steatosis and Fibrosis: Results from the MAST4HEALTH Study |
title_short | Plasma Amino Acids in NAFLD Patients with Obesity Are Associated with Steatosis and Fibrosis: Results from the MAST4HEALTH Study |
title_sort | plasma amino acids in nafld patients with obesity are associated with steatosis and fibrosis: results from the mast4health study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10456787/ https://www.ncbi.nlm.nih.gov/pubmed/37623902 http://dx.doi.org/10.3390/metabo13080959 |
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