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Cosegregation of recombinant chromatids maintains genome-wide heterozygosity in an asexual nematode

In asexual animals, female meiosis is modified to produce diploid oocytes. If meiosis still involves recombination, this is expected to lead to a rapid loss of heterozygosity, with adverse effects on fitness. Many asexuals, however, have a heterozygous genome, the underlying mechanisms being most of...

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Autores principales: Blanc, Caroline, Saclier, Nathanaelle, Le Faou, Ehouarn, Marie-Orleach, Lucas, Wenger, Eva, Diblasi, Celian, Glemin, Sylvain, Galtier, Nicolas, Delattre, Marie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10456839/
https://www.ncbi.nlm.nih.gov/pubmed/37624896
http://dx.doi.org/10.1126/sciadv.adi2804
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author Blanc, Caroline
Saclier, Nathanaelle
Le Faou, Ehouarn
Marie-Orleach, Lucas
Wenger, Eva
Diblasi, Celian
Glemin, Sylvain
Galtier, Nicolas
Delattre, Marie
author_facet Blanc, Caroline
Saclier, Nathanaelle
Le Faou, Ehouarn
Marie-Orleach, Lucas
Wenger, Eva
Diblasi, Celian
Glemin, Sylvain
Galtier, Nicolas
Delattre, Marie
author_sort Blanc, Caroline
collection PubMed
description In asexual animals, female meiosis is modified to produce diploid oocytes. If meiosis still involves recombination, this is expected to lead to a rapid loss of heterozygosity, with adverse effects on fitness. Many asexuals, however, have a heterozygous genome, the underlying mechanisms being most often unknown. Cytological and population genomic analyses in the nematode Mesorhabditis belari revealed another case of recombining asexual being highly heterozygous genome-wide. We demonstrated that heterozygosity is maintained despite recombination because the recombinant chromatids of each chromosome pair cosegregate during the unique meiotic division. A theoretical model confirmed that this segregation bias is necessary to account for the observed pattern and likely to evolve under a wide range of conditions. Our study uncovers an unexpected type of non-Mendelian genetic inheritance involving cosegregation of recombinant chromatids.
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spelling pubmed-104568392023-08-26 Cosegregation of recombinant chromatids maintains genome-wide heterozygosity in an asexual nematode Blanc, Caroline Saclier, Nathanaelle Le Faou, Ehouarn Marie-Orleach, Lucas Wenger, Eva Diblasi, Celian Glemin, Sylvain Galtier, Nicolas Delattre, Marie Sci Adv Biomedicine and Life Sciences In asexual animals, female meiosis is modified to produce diploid oocytes. If meiosis still involves recombination, this is expected to lead to a rapid loss of heterozygosity, with adverse effects on fitness. Many asexuals, however, have a heterozygous genome, the underlying mechanisms being most often unknown. Cytological and population genomic analyses in the nematode Mesorhabditis belari revealed another case of recombining asexual being highly heterozygous genome-wide. We demonstrated that heterozygosity is maintained despite recombination because the recombinant chromatids of each chromosome pair cosegregate during the unique meiotic division. A theoretical model confirmed that this segregation bias is necessary to account for the observed pattern and likely to evolve under a wide range of conditions. Our study uncovers an unexpected type of non-Mendelian genetic inheritance involving cosegregation of recombinant chromatids. American Association for the Advancement of Science 2023-08-25 /pmc/articles/PMC10456839/ /pubmed/37624896 http://dx.doi.org/10.1126/sciadv.adi2804 Text en Copyright © 2023 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY). https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution license (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Biomedicine and Life Sciences
Blanc, Caroline
Saclier, Nathanaelle
Le Faou, Ehouarn
Marie-Orleach, Lucas
Wenger, Eva
Diblasi, Celian
Glemin, Sylvain
Galtier, Nicolas
Delattre, Marie
Cosegregation of recombinant chromatids maintains genome-wide heterozygosity in an asexual nematode
title Cosegregation of recombinant chromatids maintains genome-wide heterozygosity in an asexual nematode
title_full Cosegregation of recombinant chromatids maintains genome-wide heterozygosity in an asexual nematode
title_fullStr Cosegregation of recombinant chromatids maintains genome-wide heterozygosity in an asexual nematode
title_full_unstemmed Cosegregation of recombinant chromatids maintains genome-wide heterozygosity in an asexual nematode
title_short Cosegregation of recombinant chromatids maintains genome-wide heterozygosity in an asexual nematode
title_sort cosegregation of recombinant chromatids maintains genome-wide heterozygosity in an asexual nematode
topic Biomedicine and Life Sciences
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10456839/
https://www.ncbi.nlm.nih.gov/pubmed/37624896
http://dx.doi.org/10.1126/sciadv.adi2804
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