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Structural basis of telomeric nucleosome recognition by shelterin factor TRF1

Shelterin and nucleosomes are the key players that organize mammalian chromosome ends into the protective telomere caps. However, how they interact with each other at telomeres remains unknown. We report cryo–electron microscopy structures of a human telomeric nucleosome both unbound and bound to th...

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Detalles Bibliográficos
Autores principales:	Hu, Hongmiao, van Roon, Anne-Marie M., Ghanim, George E., Ahsan, Bilal, Oluwole, Abraham O., Peak-Chew, Sew-Yeu, Robinson, Carol V., Nguyen, Thi Hoang Duong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2023
Materias:	Biomedicine and Life Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10456876/ https://www.ncbi.nlm.nih.gov/pubmed/37624885 http://dx.doi.org/10.1126/sciadv.adi4148

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