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Diagnostic and Prognostic Roles of GATA3 Immunohistochemistry in Urothelial Carcinoma
This study aimed to evaluate the diagnostic and prognostic roles of GATA-binding protein 3 (GATA3) immunohistochemistry in urothelial carcinoma (UC) using a meta-analysis. We investigated GATA3 immunohistochemical expression rates and performed a subgroup analysis based on tumor site, study location...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10456966/ https://www.ncbi.nlm.nih.gov/pubmed/37629741 http://dx.doi.org/10.3390/medicina59081452 |
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author | Yoo, Daeseon Min, Kyueng-Whan Pyo, Jung-Soo Kim, Nae Yu |
author_facet | Yoo, Daeseon Min, Kyueng-Whan Pyo, Jung-Soo Kim, Nae Yu |
author_sort | Yoo, Daeseon |
collection | PubMed |
description | This study aimed to evaluate the diagnostic and prognostic roles of GATA-binding protein 3 (GATA3) immunohistochemistry in urothelial carcinoma (UC) using a meta-analysis. We investigated GATA3 immunohistochemical expression rates and performed a subgroup analysis based on tumor site, study location, and histological subtypes. The overall survival rates of patients with GATA3-positive and -negative UC were compared. The estimated GATA3 expression rate was 0.748 (95% confidence interval [CI]: 0.704–0.787). GATA3 expression rates in the urinary bladder and urinary tract were 0.775 (95% CI: 0.727–0.818) and 0.614 (95% CI: 0.426–0.774), respectively. The GATA3 expression rates of noninvasive and invasive UCs were 0.965 (95% CI: 0.938–0.980) and 0.644 (95% CI: 0.581–0.702), respectively. In invasive UCs, there was a significant difference in GATA3 expression between non-muscular invasion and muscular invasion subgroups (0.937, 95% CI: 0.883–0.967 vs. 0.753, 95% CI: 0.645–0.836). GATA3 expression was the highest in the microcytic subtype among the histologic subtypes (0.952, 95% CI: 0.724–0.993). There was a significant correlation between GATA3 expression and better prognosis (hazard ratio: 0.402, 95% CI: 0.311–0.521). Taken together, GATA3 expression significantly correlated with low-stage and better prognosis in UC. GATA3 expression is highly variable across histological subtypes, and one should be careful while interpreting GATA3 expression. |
format | Online Article Text |
id | pubmed-10456966 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-104569662023-08-26 Diagnostic and Prognostic Roles of GATA3 Immunohistochemistry in Urothelial Carcinoma Yoo, Daeseon Min, Kyueng-Whan Pyo, Jung-Soo Kim, Nae Yu Medicina (Kaunas) Article This study aimed to evaluate the diagnostic and prognostic roles of GATA-binding protein 3 (GATA3) immunohistochemistry in urothelial carcinoma (UC) using a meta-analysis. We investigated GATA3 immunohistochemical expression rates and performed a subgroup analysis based on tumor site, study location, and histological subtypes. The overall survival rates of patients with GATA3-positive and -negative UC were compared. The estimated GATA3 expression rate was 0.748 (95% confidence interval [CI]: 0.704–0.787). GATA3 expression rates in the urinary bladder and urinary tract were 0.775 (95% CI: 0.727–0.818) and 0.614 (95% CI: 0.426–0.774), respectively. The GATA3 expression rates of noninvasive and invasive UCs were 0.965 (95% CI: 0.938–0.980) and 0.644 (95% CI: 0.581–0.702), respectively. In invasive UCs, there was a significant difference in GATA3 expression between non-muscular invasion and muscular invasion subgroups (0.937, 95% CI: 0.883–0.967 vs. 0.753, 95% CI: 0.645–0.836). GATA3 expression was the highest in the microcytic subtype among the histologic subtypes (0.952, 95% CI: 0.724–0.993). There was a significant correlation between GATA3 expression and better prognosis (hazard ratio: 0.402, 95% CI: 0.311–0.521). Taken together, GATA3 expression significantly correlated with low-stage and better prognosis in UC. GATA3 expression is highly variable across histological subtypes, and one should be careful while interpreting GATA3 expression. MDPI 2023-08-11 /pmc/articles/PMC10456966/ /pubmed/37629741 http://dx.doi.org/10.3390/medicina59081452 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Yoo, Daeseon Min, Kyueng-Whan Pyo, Jung-Soo Kim, Nae Yu Diagnostic and Prognostic Roles of GATA3 Immunohistochemistry in Urothelial Carcinoma |
title | Diagnostic and Prognostic Roles of GATA3 Immunohistochemistry in Urothelial Carcinoma |
title_full | Diagnostic and Prognostic Roles of GATA3 Immunohistochemistry in Urothelial Carcinoma |
title_fullStr | Diagnostic and Prognostic Roles of GATA3 Immunohistochemistry in Urothelial Carcinoma |
title_full_unstemmed | Diagnostic and Prognostic Roles of GATA3 Immunohistochemistry in Urothelial Carcinoma |
title_short | Diagnostic and Prognostic Roles of GATA3 Immunohistochemistry in Urothelial Carcinoma |
title_sort | diagnostic and prognostic roles of gata3 immunohistochemistry in urothelial carcinoma |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10456966/ https://www.ncbi.nlm.nih.gov/pubmed/37629741 http://dx.doi.org/10.3390/medicina59081452 |
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