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Cytokine associated with severity of depressive symptoms in female nurses in Korea
BACKGROUND: Depression has been associated with the risk of developing physical illnesses and diseases. Inflammatory hypotheses of immunoactive and dysregulated cytokine production have been proposed to describe this association; however, data pertaining to the high prevalence of depression among nu...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10457120/ https://www.ncbi.nlm.nih.gov/pubmed/37637801 http://dx.doi.org/10.3389/fpubh.2023.1194519 |
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author | Kim, Yoonjoo Pang, Yanghee Park, Hyunki Kim, Oksoo Lee, Hyangkyu |
author_facet | Kim, Yoonjoo Pang, Yanghee Park, Hyunki Kim, Oksoo Lee, Hyangkyu |
author_sort | Kim, Yoonjoo |
collection | PubMed |
description | BACKGROUND: Depression has been associated with the risk of developing physical illnesses and diseases. Inflammatory hypotheses of immunoactive and dysregulated cytokine production have been proposed to describe this association; however, data pertaining to the high prevalence of depression among nurses are limited. OBJECTIVE: This study aimed to use a comprehensive immune-profiling approach to determine whether an abnormal profile of circulating cytokines could be identified in nurses with self-reported depression and whether this profile is associated with the severity of depression. METHODS: We investigated a cohort of 157 female nurses in Korea. The self-report Patient Health Questionnaire was used to measure the depression levels of nurses. In addition, peripheral blood samples were collected and used to measure the cytokine profile using the Luminex multiplexing system. Generalized gamma regression analyses were conducted to evaluate the association between cytokine and depressive symptoms. RESULTS: Regarding severity of depressive symptoms, 28.0% of nurses had moderately severe depression while 9.6% had severe depression. Moderately-severe depressive symptoms in nurses were associated with elevated levels of interleukin-6 (B = 0.460, p = 0.003), interleukin-8 (B = 0.273, p = 0.001), and interleukin-18 (B = 0.236, p = 0.023), whereas interferon-gamma levels (B = −0.585, p = 0.003) showed the opposite profile. Participants with severe depressive symptoms presented decreased interferon-gamma levels (B = −1.254, p < 0.001). CONCLUSION: This study demonstrated that proinflammatory cytokines were associated with depression among nurses. This calls for early detection and intervention, considering the mechanisms linking depression to physical illness and disease. |
format | Online Article Text |
id | pubmed-10457120 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-104571202023-08-26 Cytokine associated with severity of depressive symptoms in female nurses in Korea Kim, Yoonjoo Pang, Yanghee Park, Hyunki Kim, Oksoo Lee, Hyangkyu Front Public Health Public Health BACKGROUND: Depression has been associated with the risk of developing physical illnesses and diseases. Inflammatory hypotheses of immunoactive and dysregulated cytokine production have been proposed to describe this association; however, data pertaining to the high prevalence of depression among nurses are limited. OBJECTIVE: This study aimed to use a comprehensive immune-profiling approach to determine whether an abnormal profile of circulating cytokines could be identified in nurses with self-reported depression and whether this profile is associated with the severity of depression. METHODS: We investigated a cohort of 157 female nurses in Korea. The self-report Patient Health Questionnaire was used to measure the depression levels of nurses. In addition, peripheral blood samples were collected and used to measure the cytokine profile using the Luminex multiplexing system. Generalized gamma regression analyses were conducted to evaluate the association between cytokine and depressive symptoms. RESULTS: Regarding severity of depressive symptoms, 28.0% of nurses had moderately severe depression while 9.6% had severe depression. Moderately-severe depressive symptoms in nurses were associated with elevated levels of interleukin-6 (B = 0.460, p = 0.003), interleukin-8 (B = 0.273, p = 0.001), and interleukin-18 (B = 0.236, p = 0.023), whereas interferon-gamma levels (B = −0.585, p = 0.003) showed the opposite profile. Participants with severe depressive symptoms presented decreased interferon-gamma levels (B = −1.254, p < 0.001). CONCLUSION: This study demonstrated that proinflammatory cytokines were associated with depression among nurses. This calls for early detection and intervention, considering the mechanisms linking depression to physical illness and disease. Frontiers Media S.A. 2023-08-10 /pmc/articles/PMC10457120/ /pubmed/37637801 http://dx.doi.org/10.3389/fpubh.2023.1194519 Text en Copyright © 2023 Kim, Pang, Park, Kim and Lee. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Public Health Kim, Yoonjoo Pang, Yanghee Park, Hyunki Kim, Oksoo Lee, Hyangkyu Cytokine associated with severity of depressive symptoms in female nurses in Korea |
title | Cytokine associated with severity of depressive symptoms in female nurses in Korea |
title_full | Cytokine associated with severity of depressive symptoms in female nurses in Korea |
title_fullStr | Cytokine associated with severity of depressive symptoms in female nurses in Korea |
title_full_unstemmed | Cytokine associated with severity of depressive symptoms in female nurses in Korea |
title_short | Cytokine associated with severity of depressive symptoms in female nurses in Korea |
title_sort | cytokine associated with severity of depressive symptoms in female nurses in korea |
topic | Public Health |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10457120/ https://www.ncbi.nlm.nih.gov/pubmed/37637801 http://dx.doi.org/10.3389/fpubh.2023.1194519 |
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