Large-scale purification of functional AAV particles packaging the full genome using short-term ultracentrifugation with a zonal rotor

Adeno-associated virus (AAV) vector-based gene therapy is potentially curative for various genetic diseases; however, the development of a scalable purification method for full-genome AAV vectors remains crucial to increase productivity and reduce cost of GMP production. In this study, we developed...

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Detalles Bibliográficos
Autores principales: Wada, Mikako, Uchida, Naoya, Posadas-Herrera, Guillermo, Hayashita-Kinoh, Hiromi, Tsunekawa, Yuji, Hirai, Yukihiko, Okada, Takashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10457186/
https://www.ncbi.nlm.nih.gov/pubmed/36977769
http://dx.doi.org/10.1038/s41434-023-00398-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10457186/
https://www.ncbi.nlm.nih.gov/pubmed/36977769
http://dx.doi.org/10.1038/s41434-023-00398-x

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