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Large-scale purification of functional AAV particles packaging the full genome using short-term ultracentrifugation with a zonal rotor
Adeno-associated virus (AAV) vector-based gene therapy is potentially curative for various genetic diseases; however, the development of a scalable purification method for full-genome AAV vectors remains crucial to increase productivity and reduce cost of GMP production. In this study, we developed...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10457186/ https://www.ncbi.nlm.nih.gov/pubmed/36977769 http://dx.doi.org/10.1038/s41434-023-00398-x |