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Culture expansion of CAR T cells results in aberrant DNA methylation that is associated with adverse clinical outcome

Chimeric antigen receptor (CAR) T cells provide new perspectives for treatment of hematological malignancies. Manufacturing of these cellular products includes culture expansion procedures, which may affect cellular integrity and therapeutic outcome. In this study, we investigated culture-associated...

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Detalles Bibliográficos
Autores principales:	Salz, Lucia, Seitz, Alexander, Schäfer, Daniel, Franzen, Julia, Holzer, Tatjana, Garcia-Prieto, Carlos A., Bürger, Iris, Hardt, Olaf, Esteller, Manel, Wagner, Wolfgang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10457202/ https://www.ncbi.nlm.nih.gov/pubmed/37452103 http://dx.doi.org/10.1038/s41375-023-01966-1

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