An IgM-like inhalable ACE2 fusion protein broadly neutralizes SARS-CoV-2 variants

Many of the currently available COVID-19 vaccines and therapeutics are not effective against newly emerged SARS-CoV-2 variants. Here, we developed the metallo-enzyme domain of angiotensin converting enzyme 2 (ACE2)—the cellular receptor of SARS-CoV-2—into an IgM-like inhalable molecule (HH-120). HH-...

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Detalles Bibliográficos
Autores principales: Liu, Juan, Mao, Fengfeng, Chen, Jianhe, Lu, Shuaiyao, Qi, Yonghe, Sun, Yinyan, Fang, Linqiang, Yeung, Man Lung, Liu, Chunmei, Yu, Guimei, Li, Guangyu, Liu, Ximing, Yao, Yuansheng, Huang, Panpan, Hao, Dongxia, Liu, Zibing, Ding, Yu, Liu, Haimo, Yang, Fang, Chen, Pan, Sa, Rigai, Sheng, Yao, Tian, Xinxin, Peng, Ran, Li, Xue, Luo, Junmian, Cheng, Yurui, Zheng, Yule, Lin, Yongqing, Song, Rui, Jin, Ronghua, Huang, Baoying, Choe, Hyeryun, Farzan, Michael, Yuen, Kwok-Yung, Tan, Wenjie, Peng, Xiaozhong, Sui, Jianhua, Li, Wenhui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10457309/
https://www.ncbi.nlm.nih.gov/pubmed/37626079
http://dx.doi.org/10.1038/s41467-023-40933-3

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