Whole genomic analysis reveals atypical non-homologous off-target large structural variants induced by CRISPR-Cas9-mediated genome editing

CRISPR-Cas9 genome editing has promising therapeutic potential for genetic diseases and cancers, but safety could be a concern. Here we use whole genomic analysis by 10x linked-read sequencing and optical genome mapping to interrogate the genome integrity after editing and in comparison to four pare...

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Detalles Bibliográficos
Autores principales: Tsai, Hsiu-Hui, Kao, Hsiao-Jung, Kuo, Ming-Wei, Lin, Chin-Hsien, Chang, Chun-Min, Chen, Yi-Yin, Chen, Hsiao-Huei, Kwok, Pui-Yan, Yu, Alice L., Yu, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10457329/
https://www.ncbi.nlm.nih.gov/pubmed/37626063
http://dx.doi.org/10.1038/s41467-023-40901-x

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