PINK1 and Parkin regulate IP(3)R-mediated ER calcium release

Although defects in intracellular calcium homeostasis are known to play a role in the pathogenesis of Parkinson’s disease (PD), the underlying molecular mechanisms remain unclear. Here, we show that loss of PTEN-induced kinase 1 (PINK1) and Parkin leads to dysregulation of inositol 1,4,5-trisphospha...

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Detalles Bibliográficos
Autores principales: Ham, Su Jin, Yoo, Heesuk, Woo, Daihn, Lee, Da Hyun, Park, Kyu-Sang, Chung, Jongkyeong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10457342/
https://www.ncbi.nlm.nih.gov/pubmed/37626046
http://dx.doi.org/10.1038/s41467-023-40929-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10457342/
https://www.ncbi.nlm.nih.gov/pubmed/37626046
http://dx.doi.org/10.1038/s41467-023-40929-z

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