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Secondary analysis of preoperative predictors for acute postoperative exacerbation in interstitial lung disease

This study assessed whether perioperative management is associated with postoperative acute exacerbations (AEs) in interstitial lung disease (ILD) patients. Using secondary data from the study “Postoperative acute exacerbation of interstitial lung disease: a case–control study,” we compared the peri...

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Autores principales: Seto, Fumiko, Kawamura, Gaku, Hosoki, Keisuke, Ushio, Michiko, Jo, Taisuke, Uchida, Kanji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10457368/
https://www.ncbi.nlm.nih.gov/pubmed/37626100
http://dx.doi.org/10.1038/s41598-023-41152-y
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author Seto, Fumiko
Kawamura, Gaku
Hosoki, Keisuke
Ushio, Michiko
Jo, Taisuke
Uchida, Kanji
author_facet Seto, Fumiko
Kawamura, Gaku
Hosoki, Keisuke
Ushio, Michiko
Jo, Taisuke
Uchida, Kanji
author_sort Seto, Fumiko
collection PubMed
description This study assessed whether perioperative management is associated with postoperative acute exacerbations (AEs) in interstitial lung disease (ILD) patients. Using secondary data from the study “Postoperative acute exacerbation of interstitial lung disease: a case–control study,” we compared the perioperative clinical management of the AE and non-AE groups (1:4 case–control matching) selected by sex, year of surgery (2009–2011, 2012–2014, and 2015–2017), and multiple surgeries within 30 days. We compared 27 and 108 patients with and without AEs, respectively. Rates of one lung ventilation (OLV) cases (70 vs. 29%; OR, 5.9; 95%CI, 2.34–14.88; p < 0.001) and intraoperative steroid administration (48 vs. 26%; OR, 2.65; 95%CI, 1.11–6.33; p = 0.028), and average mean inspiratory pressure (9.2 [1.8] vs. 8.3 [1.7] cmH(2)O; OR, 1.36; 95%CI, 1.04–1.79; p = 0.026), were significantly higher in the AE group. There was a significant difference in OLV between the groups (OR, 4.99; 95%CI, 1.90–13.06; p = 0.001). However, the fraction of inspired oxygen  > 0.8 lasting > 1 min (63 vs. 73%, p = 0.296) was not significantly different between the groups. OLV was significantly associated with postoperative AEs in patients with ILD undergoing both pulmonary and non-pulmonary surgeries. Thus, preoperative risk considerations are more important in patients who require OLV.
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spelling pubmed-104573682023-08-27 Secondary analysis of preoperative predictors for acute postoperative exacerbation in interstitial lung disease Seto, Fumiko Kawamura, Gaku Hosoki, Keisuke Ushio, Michiko Jo, Taisuke Uchida, Kanji Sci Rep Article This study assessed whether perioperative management is associated with postoperative acute exacerbations (AEs) in interstitial lung disease (ILD) patients. Using secondary data from the study “Postoperative acute exacerbation of interstitial lung disease: a case–control study,” we compared the perioperative clinical management of the AE and non-AE groups (1:4 case–control matching) selected by sex, year of surgery (2009–2011, 2012–2014, and 2015–2017), and multiple surgeries within 30 days. We compared 27 and 108 patients with and without AEs, respectively. Rates of one lung ventilation (OLV) cases (70 vs. 29%; OR, 5.9; 95%CI, 2.34–14.88; p < 0.001) and intraoperative steroid administration (48 vs. 26%; OR, 2.65; 95%CI, 1.11–6.33; p = 0.028), and average mean inspiratory pressure (9.2 [1.8] vs. 8.3 [1.7] cmH(2)O; OR, 1.36; 95%CI, 1.04–1.79; p = 0.026), were significantly higher in the AE group. There was a significant difference in OLV between the groups (OR, 4.99; 95%CI, 1.90–13.06; p = 0.001). However, the fraction of inspired oxygen  > 0.8 lasting > 1 min (63 vs. 73%, p = 0.296) was not significantly different between the groups. OLV was significantly associated with postoperative AEs in patients with ILD undergoing both pulmonary and non-pulmonary surgeries. Thus, preoperative risk considerations are more important in patients who require OLV. Nature Publishing Group UK 2023-08-25 /pmc/articles/PMC10457368/ /pubmed/37626100 http://dx.doi.org/10.1038/s41598-023-41152-y Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Seto, Fumiko
Kawamura, Gaku
Hosoki, Keisuke
Ushio, Michiko
Jo, Taisuke
Uchida, Kanji
Secondary analysis of preoperative predictors for acute postoperative exacerbation in interstitial lung disease
title Secondary analysis of preoperative predictors for acute postoperative exacerbation in interstitial lung disease
title_full Secondary analysis of preoperative predictors for acute postoperative exacerbation in interstitial lung disease
title_fullStr Secondary analysis of preoperative predictors for acute postoperative exacerbation in interstitial lung disease
title_full_unstemmed Secondary analysis of preoperative predictors for acute postoperative exacerbation in interstitial lung disease
title_short Secondary analysis of preoperative predictors for acute postoperative exacerbation in interstitial lung disease
title_sort secondary analysis of preoperative predictors for acute postoperative exacerbation in interstitial lung disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10457368/
https://www.ncbi.nlm.nih.gov/pubmed/37626100
http://dx.doi.org/10.1038/s41598-023-41152-y
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