Targeted deletion of von-Hippel-Lindau in the proximal tubule conditions the kidney against early diabetic kidney disease

Diabetic kidney disease (DKD) is the leading cause of end-stage renal disease. Glomerular hyperfiltration and albuminuria subject the proximal tubule (PT) to a subsequent elevation of workload, growth, and hypoxia. Hypoxia plays an ambiguous role in the development and progression of DKD and shall b...

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Detalles Bibliográficos
Autores principales: Kunke, Madlen, Knöfler, Hannah, Dahlke, Eileen, Zanon Rodriguez, Luis, Böttner, Martina, Larionov, Alexey, Saudenova, Makhabbat, Ohrenschall, Gerrit M., Westermann, Magdalena, Porubsky, Stefan, Bernardes, Joana P., Häsler, Robert, Magnin, Jean-Luc, Koepsell, Hermann, Jouret, François, Theilig, Franziska
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10457389/
https://www.ncbi.nlm.nih.gov/pubmed/37626062
http://dx.doi.org/10.1038/s41419-023-06074-7

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