The disordered C terminus of ALKBH5 promotes phase separation and paraspeckles assembly

Paraspeckles (PS) are nuclear structures scaffolded by the long noncoding RNA NEAT1 and protein components such as NONO and SFPQ. We previously found that the upregulation of RNA N6-methyl-adenosine (m(6)A) demethylase ALKBH5 facilitates hypoxia-induced paraspeckle assembly through erasing m(6)A mar...

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Detalles Bibliográficos
Autores principales: Qin, Xiaoyang, Long, Yan, Bai, Xue, Cao, Lei, Yan, Han, Zhang, Kai, Wang, Bo, Wu, Xudong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10457456/
https://www.ncbi.nlm.nih.gov/pubmed/37474102
http://dx.doi.org/10.1016/j.jbc.2023.105071

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