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The human neuroprotective placental protein composition suppressing tinnitus and restoring auditory brainstem response in a rodent model of sodium salicylate-induced ototoxicity

The effect of neuroprotective placental protein composition (NPPC) on the suppression of tinnitus and the restoration of the auditory brainstem response (ABR) characteristics was explored in tinnitus-induced rats. The animals were placed into two groups: (1) the study group, rats received sodium sal...

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Autores principales: Farhadi, Mohammad, Gorji, Ali, Mirsalehi, Marjan, Müller, Marcus, Poletaev, Alexander Borisovich, Mahboudi, Fereidoun, Asadpour, Abdoreza, Ebrahimi, Mohammad, Beiranvand, Mohaddeseh, Khaftari, Mohaddeseh Dehghani, Akbarnejad, Zeinab, Mahmoudian, Saeid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10457515/
https://www.ncbi.nlm.nih.gov/pubmed/37636471
http://dx.doi.org/10.1016/j.heliyon.2023.e19052
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author Farhadi, Mohammad
Gorji, Ali
Mirsalehi, Marjan
Müller, Marcus
Poletaev, Alexander Borisovich
Mahboudi, Fereidoun
Asadpour, Abdoreza
Ebrahimi, Mohammad
Beiranvand, Mohaddeseh
Khaftari, Mohaddeseh Dehghani
Akbarnejad, Zeinab
Mahmoudian, Saeid
author_facet Farhadi, Mohammad
Gorji, Ali
Mirsalehi, Marjan
Müller, Marcus
Poletaev, Alexander Borisovich
Mahboudi, Fereidoun
Asadpour, Abdoreza
Ebrahimi, Mohammad
Beiranvand, Mohaddeseh
Khaftari, Mohaddeseh Dehghani
Akbarnejad, Zeinab
Mahmoudian, Saeid
author_sort Farhadi, Mohammad
collection PubMed
description The effect of neuroprotective placental protein composition (NPPC) on the suppression of tinnitus and the restoration of the auditory brainstem response (ABR) characteristics was explored in tinnitus-induced rats. The animals were placed into two groups: (1) the study group, rats received sodium salicylate (SS) at the dose of 200 mg/kg twice a day for two weeks, and then 0.4 mg of the NPPC per day, between the 14th and 28th days, (2) the placebo group, rats received saline for two weeks, and then the NPPC alone between the 14th and 28th days. The gap pre-pulse inhibition of the acoustic startle (GPIAS), the pre-pulse inhibition (PPI), and the ABR assessments were performed on animals in both groups three times (baseline, day 14, and 28). The GPIAS value declined after 14 consecutive days of the SS injection, while NPPC treatment augmented the GPIAS score in the study group on the 28th day. The PPI outcomes revealed no significant changes, indicating hearing preservation after the SS and NPPC administrations. Moreover, some changes in ABR characteristics were observed following SS injection, including (1) higher ABR thresholds, (2) lowered waves I and II amplitudes at the frequencies of 6, 12, and 24 kHz and wave III at the 12 kHz, (3) elevated amplitude ratios, and (4) prolongation in brainstem transmission time (BTT). All the mentioned variables returned to their normal values after applying the NPPC. The NPPC use could exert positive therapeutic effects on the tinnitus-induced rats and improve their ABR parameters.
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spelling pubmed-104575152023-08-27 The human neuroprotective placental protein composition suppressing tinnitus and restoring auditory brainstem response in a rodent model of sodium salicylate-induced ototoxicity Farhadi, Mohammad Gorji, Ali Mirsalehi, Marjan Müller, Marcus Poletaev, Alexander Borisovich Mahboudi, Fereidoun Asadpour, Abdoreza Ebrahimi, Mohammad Beiranvand, Mohaddeseh Khaftari, Mohaddeseh Dehghani Akbarnejad, Zeinab Mahmoudian, Saeid Heliyon Research Article The effect of neuroprotective placental protein composition (NPPC) on the suppression of tinnitus and the restoration of the auditory brainstem response (ABR) characteristics was explored in tinnitus-induced rats. The animals were placed into two groups: (1) the study group, rats received sodium salicylate (SS) at the dose of 200 mg/kg twice a day for two weeks, and then 0.4 mg of the NPPC per day, between the 14th and 28th days, (2) the placebo group, rats received saline for two weeks, and then the NPPC alone between the 14th and 28th days. The gap pre-pulse inhibition of the acoustic startle (GPIAS), the pre-pulse inhibition (PPI), and the ABR assessments were performed on animals in both groups three times (baseline, day 14, and 28). The GPIAS value declined after 14 consecutive days of the SS injection, while NPPC treatment augmented the GPIAS score in the study group on the 28th day. The PPI outcomes revealed no significant changes, indicating hearing preservation after the SS and NPPC administrations. Moreover, some changes in ABR characteristics were observed following SS injection, including (1) higher ABR thresholds, (2) lowered waves I and II amplitudes at the frequencies of 6, 12, and 24 kHz and wave III at the 12 kHz, (3) elevated amplitude ratios, and (4) prolongation in brainstem transmission time (BTT). All the mentioned variables returned to their normal values after applying the NPPC. The NPPC use could exert positive therapeutic effects on the tinnitus-induced rats and improve their ABR parameters. Elsevier 2023-08-11 /pmc/articles/PMC10457515/ /pubmed/37636471 http://dx.doi.org/10.1016/j.heliyon.2023.e19052 Text en © 2023 Published by Elsevier Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Research Article
Farhadi, Mohammad
Gorji, Ali
Mirsalehi, Marjan
Müller, Marcus
Poletaev, Alexander Borisovich
Mahboudi, Fereidoun
Asadpour, Abdoreza
Ebrahimi, Mohammad
Beiranvand, Mohaddeseh
Khaftari, Mohaddeseh Dehghani
Akbarnejad, Zeinab
Mahmoudian, Saeid
The human neuroprotective placental protein composition suppressing tinnitus and restoring auditory brainstem response in a rodent model of sodium salicylate-induced ototoxicity
title The human neuroprotective placental protein composition suppressing tinnitus and restoring auditory brainstem response in a rodent model of sodium salicylate-induced ototoxicity
title_full The human neuroprotective placental protein composition suppressing tinnitus and restoring auditory brainstem response in a rodent model of sodium salicylate-induced ototoxicity
title_fullStr The human neuroprotective placental protein composition suppressing tinnitus and restoring auditory brainstem response in a rodent model of sodium salicylate-induced ototoxicity
title_full_unstemmed The human neuroprotective placental protein composition suppressing tinnitus and restoring auditory brainstem response in a rodent model of sodium salicylate-induced ototoxicity
title_short The human neuroprotective placental protein composition suppressing tinnitus and restoring auditory brainstem response in a rodent model of sodium salicylate-induced ototoxicity
title_sort human neuroprotective placental protein composition suppressing tinnitus and restoring auditory brainstem response in a rodent model of sodium salicylate-induced ototoxicity
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10457515/
https://www.ncbi.nlm.nih.gov/pubmed/37636471
http://dx.doi.org/10.1016/j.heliyon.2023.e19052
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