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Knowledge Translation in Glomerulonephritis: Successes in Translational Research From the Bench to Bedside

PURPOSE OF REVIEW: Glomerulonephritis refers to a rare group of diseases characterized by glomerular inflammation, which collectively are a common cause of kidney failure. Until recently, there was a lack of high-quality clinical trials to inform the care of patients with glomerulonephritides. We id...

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Autores principales: Yau, Kevin, Wang, Carol, Al Batran, Rami, Macphee, Anne, Beaucage, Mary, Farragher, Janine F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10457520/
https://www.ncbi.nlm.nih.gov/pubmed/37637870
http://dx.doi.org/10.1177/20543581231191839
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author Yau, Kevin
Wang, Carol
Al Batran, Rami
Macphee, Anne
Beaucage, Mary
Farragher, Janine F.
author_facet Yau, Kevin
Wang, Carol
Al Batran, Rami
Macphee, Anne
Beaucage, Mary
Farragher, Janine F.
author_sort Yau, Kevin
collection PubMed
description PURPOSE OF REVIEW: Glomerulonephritis refers to a rare group of diseases characterized by glomerular inflammation, which collectively are a common cause of kidney failure. Until recently, there was a lack of high-quality clinical trials to inform the care of patients with glomerulonephritides. We identified examples of successful translational research spanning from basic science to clinical applications, and highlight gaps in implementation science. SOURCES OF INFORMATION: The focus of our review was derived from discussions between health care professionals, researchers, and patient partners. We also performed literature searches pertaining to the treatment of glomerulonephritis in PubMed and Google Scholar. METHODS: Examples of successful knowledge translation were generated through review of new evidence in the past 5 years and by iterative discussions by the authors. We then conducted a narrative review of several themes related to knowledge translation in glomerulonephritis. This was complemented by an interview with a patient partner to provide an example of a patient’s perspective living with glomerulonephritis. KEY FINDINGS: We summarized selected recent advances in glomerulonephritis and its knowledge translation in the following domains: (1) identification of auto-antibodies in membranous nephropathy and minimal change disease; (2) clinical trials of novel targeted therapies for IgA nephropathy and lupus nephritis, which have led to approval of new treatments; (3) developments in research networks and clinical trials in glomerulonephritis; (4) recognition of the importance in developing standardized patient reported outcome measures in clinical trials; and (5) barriers in knowledge translation including access to medication. LIMITATIONS: A systematic search of the literature and formal assessment of quality of evidence were beyond the scope of this review.
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spelling pubmed-104575202023-08-27 Knowledge Translation in Glomerulonephritis: Successes in Translational Research From the Bench to Bedside Yau, Kevin Wang, Carol Al Batran, Rami Macphee, Anne Beaucage, Mary Farragher, Janine F. Can J Kidney Health Dis Narrative Review PURPOSE OF REVIEW: Glomerulonephritis refers to a rare group of diseases characterized by glomerular inflammation, which collectively are a common cause of kidney failure. Until recently, there was a lack of high-quality clinical trials to inform the care of patients with glomerulonephritides. We identified examples of successful translational research spanning from basic science to clinical applications, and highlight gaps in implementation science. SOURCES OF INFORMATION: The focus of our review was derived from discussions between health care professionals, researchers, and patient partners. We also performed literature searches pertaining to the treatment of glomerulonephritis in PubMed and Google Scholar. METHODS: Examples of successful knowledge translation were generated through review of new evidence in the past 5 years and by iterative discussions by the authors. We then conducted a narrative review of several themes related to knowledge translation in glomerulonephritis. This was complemented by an interview with a patient partner to provide an example of a patient’s perspective living with glomerulonephritis. KEY FINDINGS: We summarized selected recent advances in glomerulonephritis and its knowledge translation in the following domains: (1) identification of auto-antibodies in membranous nephropathy and minimal change disease; (2) clinical trials of novel targeted therapies for IgA nephropathy and lupus nephritis, which have led to approval of new treatments; (3) developments in research networks and clinical trials in glomerulonephritis; (4) recognition of the importance in developing standardized patient reported outcome measures in clinical trials; and (5) barriers in knowledge translation including access to medication. LIMITATIONS: A systematic search of the literature and formal assessment of quality of evidence were beyond the scope of this review. SAGE Publications 2023-08-23 /pmc/articles/PMC10457520/ /pubmed/37637870 http://dx.doi.org/10.1177/20543581231191839 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Narrative Review
Yau, Kevin
Wang, Carol
Al Batran, Rami
Macphee, Anne
Beaucage, Mary
Farragher, Janine F.
Knowledge Translation in Glomerulonephritis: Successes in Translational Research From the Bench to Bedside
title Knowledge Translation in Glomerulonephritis: Successes in Translational Research From the Bench to Bedside
title_full Knowledge Translation in Glomerulonephritis: Successes in Translational Research From the Bench to Bedside
title_fullStr Knowledge Translation in Glomerulonephritis: Successes in Translational Research From the Bench to Bedside
title_full_unstemmed Knowledge Translation in Glomerulonephritis: Successes in Translational Research From the Bench to Bedside
title_short Knowledge Translation in Glomerulonephritis: Successes in Translational Research From the Bench to Bedside
title_sort knowledge translation in glomerulonephritis: successes in translational research from the bench to bedside
topic Narrative Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10457520/
https://www.ncbi.nlm.nih.gov/pubmed/37637870
http://dx.doi.org/10.1177/20543581231191839
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