AARDVARK: an automated reversion detector for variants affecting resistance kinetics

SUMMARY: Resistance to two classes of FDA-approved therapies that target DNA repair-deficient tumors is caused by mutations that restore the tumor cell's DNA repair function. Identifying these “reversion” mutations currently requires manual annotation of patient tumor sequence data. Here we pre...

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Detalles Bibliográficos
Autores principales: Moreno, Thaidy, Magana, Joaquin, Quigley, David A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Applications Note
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10457659/
https://www.ncbi.nlm.nih.gov/pubmed/37584701
http://dx.doi.org/10.1093/bioinformatics/btad509

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10457659/
https://www.ncbi.nlm.nih.gov/pubmed/37584701
http://dx.doi.org/10.1093/bioinformatics/btad509

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