Combined clarification and affinity capture using magnetic resin enables efficient separation of rAAV5 from cell lysate

Recombinant adeno-associated virus (rAAV) vectors have displayed enormous potential as a platform for delivery of gene therapies. Purification of rAAV at industrial scale involves a series of elaborate, material, and time-consuming midstream steps, such as clarification by depth filtration and conce...

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Detalles Bibliográficos
Autores principales: Turco, Federico, Wegelius, Adam, Lind, Ola, Norrman, Nils, Magnusson, Ann-Christin, Sund-Lundström, Christine, Norén, Björn, Hedberg, Jesper, Palmgren, Ronnie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10457685/
https://www.ncbi.nlm.nih.gov/pubmed/37637382
http://dx.doi.org/10.1016/j.omtm.2023.07.010

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10457685/
https://www.ncbi.nlm.nih.gov/pubmed/37637382
http://dx.doi.org/10.1016/j.omtm.2023.07.010

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