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Combined clarification and affinity capture using magnetic resin enables efficient separation of rAAV5 from cell lysate
Recombinant adeno-associated virus (rAAV) vectors have displayed enormous potential as a platform for delivery of gene therapies. Purification of rAAV at industrial scale involves a series of elaborate, material, and time-consuming midstream steps, such as clarification by depth filtration and conce...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Society of Gene & Cell Therapy
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10457685/ https://www.ncbi.nlm.nih.gov/pubmed/37637382 http://dx.doi.org/10.1016/j.omtm.2023.07.010 |