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Uterine Anaphylaxis Due to Subcutaneous Immunotherapy (SCIT) for Inhalant Allergens: A Case Series

Subcutaneous immunotherapy (SCIT), commonly known as “allergy shots,” aims to achieve a clinical tolerance for allergens that cause symptoms of allergic rhinoconjunctivitis, allergic asthma, or insect sting allergies. Systemic reactions to SCIT are classified in severity from one organ system (grade...

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Detalles Bibliográficos
Autores principales: Ganguli, Malika P, Sinha, Shayan, Dimov, Vesselin, Eidelman, Frank
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10457715/
https://www.ncbi.nlm.nih.gov/pubmed/37637630
http://dx.doi.org/10.7759/cureus.42526
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author Ganguli, Malika P
Sinha, Shayan
Dimov, Vesselin
Eidelman, Frank
author_facet Ganguli, Malika P
Sinha, Shayan
Dimov, Vesselin
Eidelman, Frank
author_sort Ganguli, Malika P
collection PubMed
description Subcutaneous immunotherapy (SCIT), commonly known as “allergy shots,” aims to achieve a clinical tolerance for allergens that cause symptoms of allergic rhinoconjunctivitis, allergic asthma, or insect sting allergies. Systemic reactions to SCIT are classified in severity from one organ system (grade 1) to anaphylaxis that potentially may have a fatal outcome (grade 5). Uterine cramps fall under grade 2, and they are rarely reported during SCIT. In this study, we report four cases of uterine anaphylaxis following SCIT for environmental allergens with symptoms such as severe lower abdominal cramping resembling menstrual cramps. Patients also experienced urticaria, angioedema, diffuse erythema, and flushing. None of the patients experienced uterine bleeding. To the best of our knowledge, this is the largest case series reporting this reaction to SCIT. We accompany this finding with a review of the literature on this rare but interesting topic.
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spelling pubmed-104577152023-08-27 Uterine Anaphylaxis Due to Subcutaneous Immunotherapy (SCIT) for Inhalant Allergens: A Case Series Ganguli, Malika P Sinha, Shayan Dimov, Vesselin Eidelman, Frank Cureus Family/General Practice Subcutaneous immunotherapy (SCIT), commonly known as “allergy shots,” aims to achieve a clinical tolerance for allergens that cause symptoms of allergic rhinoconjunctivitis, allergic asthma, or insect sting allergies. Systemic reactions to SCIT are classified in severity from one organ system (grade 1) to anaphylaxis that potentially may have a fatal outcome (grade 5). Uterine cramps fall under grade 2, and they are rarely reported during SCIT. In this study, we report four cases of uterine anaphylaxis following SCIT for environmental allergens with symptoms such as severe lower abdominal cramping resembling menstrual cramps. Patients also experienced urticaria, angioedema, diffuse erythema, and flushing. None of the patients experienced uterine bleeding. To the best of our knowledge, this is the largest case series reporting this reaction to SCIT. We accompany this finding with a review of the literature on this rare but interesting topic. Cureus 2023-07-27 /pmc/articles/PMC10457715/ /pubmed/37637630 http://dx.doi.org/10.7759/cureus.42526 Text en Copyright © 2023, Ganguli et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Family/General Practice
Ganguli, Malika P
Sinha, Shayan
Dimov, Vesselin
Eidelman, Frank
Uterine Anaphylaxis Due to Subcutaneous Immunotherapy (SCIT) for Inhalant Allergens: A Case Series
title Uterine Anaphylaxis Due to Subcutaneous Immunotherapy (SCIT) for Inhalant Allergens: A Case Series
title_full Uterine Anaphylaxis Due to Subcutaneous Immunotherapy (SCIT) for Inhalant Allergens: A Case Series
title_fullStr Uterine Anaphylaxis Due to Subcutaneous Immunotherapy (SCIT) for Inhalant Allergens: A Case Series
title_full_unstemmed Uterine Anaphylaxis Due to Subcutaneous Immunotherapy (SCIT) for Inhalant Allergens: A Case Series
title_short Uterine Anaphylaxis Due to Subcutaneous Immunotherapy (SCIT) for Inhalant Allergens: A Case Series
title_sort uterine anaphylaxis due to subcutaneous immunotherapy (scit) for inhalant allergens: a case series
topic Family/General Practice
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10457715/
https://www.ncbi.nlm.nih.gov/pubmed/37637630
http://dx.doi.org/10.7759/cureus.42526
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