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The Magic Methyl and Its Tricks in Drug Discovery and Development

One of the key scientific aspects of small-molecule drug discovery and development is the analysis of the relationship between its chemical structure and biological activity. Understanding the effects that lead to significant changes in biological activity is of paramount importance for the rational...

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Autores principales: Pinheiro, Pedro de Sena Murteira, Franco, Lucas Silva, Fraga, Carlos Alberto Manssour
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10457765/
https://www.ncbi.nlm.nih.gov/pubmed/37631072
http://dx.doi.org/10.3390/ph16081157
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author Pinheiro, Pedro de Sena Murteira
Franco, Lucas Silva
Fraga, Carlos Alberto Manssour
author_facet Pinheiro, Pedro de Sena Murteira
Franco, Lucas Silva
Fraga, Carlos Alberto Manssour
author_sort Pinheiro, Pedro de Sena Murteira
collection PubMed
description One of the key scientific aspects of small-molecule drug discovery and development is the analysis of the relationship between its chemical structure and biological activity. Understanding the effects that lead to significant changes in biological activity is of paramount importance for the rational design and optimization of bioactive molecules. The “methylation effect”, or the “magic methyl” effect, is a factor that stands out due to the number of examples that demonstrate profound changes in either pharmacodynamic or pharmacokinetic properties. In many cases, this has been carried out rationally, but in others it has been the product of serendipitous observations. This paper summarizes recent examples that provide an overview of the current state of the art and contribute to a better understanding of the methylation effect in bioactive small-molecule drug candidates.
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spelling pubmed-104577652023-08-27 The Magic Methyl and Its Tricks in Drug Discovery and Development Pinheiro, Pedro de Sena Murteira Franco, Lucas Silva Fraga, Carlos Alberto Manssour Pharmaceuticals (Basel) Review One of the key scientific aspects of small-molecule drug discovery and development is the analysis of the relationship between its chemical structure and biological activity. Understanding the effects that lead to significant changes in biological activity is of paramount importance for the rational design and optimization of bioactive molecules. The “methylation effect”, or the “magic methyl” effect, is a factor that stands out due to the number of examples that demonstrate profound changes in either pharmacodynamic or pharmacokinetic properties. In many cases, this has been carried out rationally, but in others it has been the product of serendipitous observations. This paper summarizes recent examples that provide an overview of the current state of the art and contribute to a better understanding of the methylation effect in bioactive small-molecule drug candidates. MDPI 2023-08-15 /pmc/articles/PMC10457765/ /pubmed/37631072 http://dx.doi.org/10.3390/ph16081157 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Pinheiro, Pedro de Sena Murteira
Franco, Lucas Silva
Fraga, Carlos Alberto Manssour
The Magic Methyl and Its Tricks in Drug Discovery and Development
title The Magic Methyl and Its Tricks in Drug Discovery and Development
title_full The Magic Methyl and Its Tricks in Drug Discovery and Development
title_fullStr The Magic Methyl and Its Tricks in Drug Discovery and Development
title_full_unstemmed The Magic Methyl and Its Tricks in Drug Discovery and Development
title_short The Magic Methyl and Its Tricks in Drug Discovery and Development
title_sort magic methyl and its tricks in drug discovery and development
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10457765/
https://www.ncbi.nlm.nih.gov/pubmed/37631072
http://dx.doi.org/10.3390/ph16081157
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