Effects of In Vitro Digestion of Polyphenols from Coffee on Binding Parameters to Human Topoisomerase II α

Type II topoisomerase (TOPII) is an enzyme that influences the topology of DNA. DNA breaks generated by TOPII may result in mutagenic or cytotoxic changes in cancer cells. In this study, we characterized interactions of TOPIIα with coffee extracts and individual chlorogenic acids (CHAs) from the ext...

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Detalles Bibliográficos
Autores principales: Grzelczyk, Joanna, Pérez-Sánchez, Horacio, Carmena-Bargueño, Miguel, Oracz, Joanna, Budryn, Grażyna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10457778/
https://www.ncbi.nlm.nih.gov/pubmed/37630250
http://dx.doi.org/10.3390/molecules28165996

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10457778/
https://www.ncbi.nlm.nih.gov/pubmed/37630250
http://dx.doi.org/10.3390/molecules28165996

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