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Effects of In Vitro Digestion of Polyphenols from Coffee on Binding Parameters to Human Topoisomerase II α
Type II topoisomerase (TOPII) is an enzyme that influences the topology of DNA. DNA breaks generated by TOPII may result in mutagenic or cytotoxic changes in cancer cells. In this study, we characterized interactions of TOPIIα with coffee extracts and individual chlorogenic acids (CHAs) from the ext...
Autores principales: | Grzelczyk, Joanna, Pérez-Sánchez, Horacio, Carmena-Bargueño, Miguel, Oracz, Joanna, Budryn, Grażyna |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10457778/ https://www.ncbi.nlm.nih.gov/pubmed/37630250 http://dx.doi.org/10.3390/molecules28165996 |
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