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Brain Tuberculosis: An Odyssey through Time to Understand This Pathology

Tuberculosis is a contagious disease that has been a concern for humanity throughout history, being recognized and referred to as the white plague. Since ancient times, starting with Hippocrates and Galen of Pergamon, doctors and scientists have attempted to understand the pathogenesis of tuberculos...

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Autores principales: Patrascu, Raluca Elena, Cucu, Andrei Ionut, Costea, Claudia Florida, Cosman, Mihaela, Blaj, Laurentiu Andrei, Hristea, Adriana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10457825/
https://www.ncbi.nlm.nih.gov/pubmed/37623986
http://dx.doi.org/10.3390/pathogens12081026
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author Patrascu, Raluca Elena
Cucu, Andrei Ionut
Costea, Claudia Florida
Cosman, Mihaela
Blaj, Laurentiu Andrei
Hristea, Adriana
author_facet Patrascu, Raluca Elena
Cucu, Andrei Ionut
Costea, Claudia Florida
Cosman, Mihaela
Blaj, Laurentiu Andrei
Hristea, Adriana
author_sort Patrascu, Raluca Elena
collection PubMed
description Tuberculosis is a contagious disease that has been a concern for humanity throughout history, being recognized and referred to as the white plague. Since ancient times, starting with Hippocrates and Galen of Pergamon, doctors and scientists have attempted to understand the pathogenesis of tuberculosis and its manifestations in the brain. If, in the medieval period, it was believed that only the touch of a king could cure the disease, it was only in the early 17th and 18th centuries that the first descriptions of tuberculous meningitis and the first clinico-pathological correlations began to emerge. While the understanding of neurotuberculosis progressed slowly, it was only after the discovery of the pathogenic agent in the late 19th century that there was an upward curve in the occurrence of treatment methods. This review aims to embark on an odyssey through the centuries, from ancient Egypt to the modern era, and explore the key moments that have contributed to the emergence of a new era of hope in the history of neurotuberculosis. Understanding the history of treatment methods against this disease, from empirical and primitive ones to the emergence of new drugs used in multi-drug-resistant tuberculosis, leads us, once again, to realize the significant contribution of science and medicine in treating a disease that was considered incurable not long ago.
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spelling pubmed-104578252023-08-27 Brain Tuberculosis: An Odyssey through Time to Understand This Pathology Patrascu, Raluca Elena Cucu, Andrei Ionut Costea, Claudia Florida Cosman, Mihaela Blaj, Laurentiu Andrei Hristea, Adriana Pathogens Review Tuberculosis is a contagious disease that has been a concern for humanity throughout history, being recognized and referred to as the white plague. Since ancient times, starting with Hippocrates and Galen of Pergamon, doctors and scientists have attempted to understand the pathogenesis of tuberculosis and its manifestations in the brain. If, in the medieval period, it was believed that only the touch of a king could cure the disease, it was only in the early 17th and 18th centuries that the first descriptions of tuberculous meningitis and the first clinico-pathological correlations began to emerge. While the understanding of neurotuberculosis progressed slowly, it was only after the discovery of the pathogenic agent in the late 19th century that there was an upward curve in the occurrence of treatment methods. This review aims to embark on an odyssey through the centuries, from ancient Egypt to the modern era, and explore the key moments that have contributed to the emergence of a new era of hope in the history of neurotuberculosis. Understanding the history of treatment methods against this disease, from empirical and primitive ones to the emergence of new drugs used in multi-drug-resistant tuberculosis, leads us, once again, to realize the significant contribution of science and medicine in treating a disease that was considered incurable not long ago. MDPI 2023-08-09 /pmc/articles/PMC10457825/ /pubmed/37623986 http://dx.doi.org/10.3390/pathogens12081026 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Patrascu, Raluca Elena
Cucu, Andrei Ionut
Costea, Claudia Florida
Cosman, Mihaela
Blaj, Laurentiu Andrei
Hristea, Adriana
Brain Tuberculosis: An Odyssey through Time to Understand This Pathology
title Brain Tuberculosis: An Odyssey through Time to Understand This Pathology
title_full Brain Tuberculosis: An Odyssey through Time to Understand This Pathology
title_fullStr Brain Tuberculosis: An Odyssey through Time to Understand This Pathology
title_full_unstemmed Brain Tuberculosis: An Odyssey through Time to Understand This Pathology
title_short Brain Tuberculosis: An Odyssey through Time to Understand This Pathology
title_sort brain tuberculosis: an odyssey through time to understand this pathology
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10457825/
https://www.ncbi.nlm.nih.gov/pubmed/37623986
http://dx.doi.org/10.3390/pathogens12081026
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