Cargando…

Granulomatous Secondary Syphilis: A Case Report with a Brief Overview of the Diagnostic Role of Immunohistochemistry

The diagnosis of syphilis can be challenging for dermatologists and dermatopathologists. In particular, secondary syphilis can have different clinical and histopathological presentations. A granulomatous tissue response is an unusual finding in secondary syphilis. We report the case of a 77-year-old...

Descripción completa

Detalles Bibliográficos
Autores principales: Ambrogio, Francesca, Cazzato, Gerardo, Foti, Caterina, Grandolfo, Mauro, Mennuni, Gisella Biagina, Vena, Gino Antonio, Cassano, Nicoletta, Lettini, Teresa, Castronovi, Cosimo, Ingordo, Vito, Romita, Paolo, Filotico, Raffaele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10457844/
https://www.ncbi.nlm.nih.gov/pubmed/37624014
http://dx.doi.org/10.3390/pathogens12081054
_version_ 1785097022179639296
author Ambrogio, Francesca
Cazzato, Gerardo
Foti, Caterina
Grandolfo, Mauro
Mennuni, Gisella Biagina
Vena, Gino Antonio
Cassano, Nicoletta
Lettini, Teresa
Castronovi, Cosimo
Ingordo, Vito
Romita, Paolo
Filotico, Raffaele
author_facet Ambrogio, Francesca
Cazzato, Gerardo
Foti, Caterina
Grandolfo, Mauro
Mennuni, Gisella Biagina
Vena, Gino Antonio
Cassano, Nicoletta
Lettini, Teresa
Castronovi, Cosimo
Ingordo, Vito
Romita, Paolo
Filotico, Raffaele
author_sort Ambrogio, Francesca
collection PubMed
description The diagnosis of syphilis can be challenging for dermatologists and dermatopathologists. In particular, secondary syphilis can have different clinical and histopathological presentations. A granulomatous tissue response is an unusual finding in secondary syphilis. We report the case of a 77-year-old man who presented with a 4-week history of non-pruritic generalised macules, papules, nodules and plaques. Histopathologically, there was a dense perivascular and periadnexal lympho-histiocytic dermal infiltrate with non-palisading and non-caseifying epithelioid granulomas and abundant plasma cells. The diagnosis of syphilis was confirmed by serology and immunohistochemical detection of Treponema pallidum in the biopsy specimen. A brief overview of the diagnostic role of immunohistochemistry is also provided, with particular emphasis on reported cases of granulomatous secondary syphilis.
format Online
Article
Text
id pubmed-10457844
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-104578442023-08-27 Granulomatous Secondary Syphilis: A Case Report with a Brief Overview of the Diagnostic Role of Immunohistochemistry Ambrogio, Francesca Cazzato, Gerardo Foti, Caterina Grandolfo, Mauro Mennuni, Gisella Biagina Vena, Gino Antonio Cassano, Nicoletta Lettini, Teresa Castronovi, Cosimo Ingordo, Vito Romita, Paolo Filotico, Raffaele Pathogens Case Report The diagnosis of syphilis can be challenging for dermatologists and dermatopathologists. In particular, secondary syphilis can have different clinical and histopathological presentations. A granulomatous tissue response is an unusual finding in secondary syphilis. We report the case of a 77-year-old man who presented with a 4-week history of non-pruritic generalised macules, papules, nodules and plaques. Histopathologically, there was a dense perivascular and periadnexal lympho-histiocytic dermal infiltrate with non-palisading and non-caseifying epithelioid granulomas and abundant plasma cells. The diagnosis of syphilis was confirmed by serology and immunohistochemical detection of Treponema pallidum in the biopsy specimen. A brief overview of the diagnostic role of immunohistochemistry is also provided, with particular emphasis on reported cases of granulomatous secondary syphilis. MDPI 2023-08-18 /pmc/articles/PMC10457844/ /pubmed/37624014 http://dx.doi.org/10.3390/pathogens12081054 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Ambrogio, Francesca
Cazzato, Gerardo
Foti, Caterina
Grandolfo, Mauro
Mennuni, Gisella Biagina
Vena, Gino Antonio
Cassano, Nicoletta
Lettini, Teresa
Castronovi, Cosimo
Ingordo, Vito
Romita, Paolo
Filotico, Raffaele
Granulomatous Secondary Syphilis: A Case Report with a Brief Overview of the Diagnostic Role of Immunohistochemistry
title Granulomatous Secondary Syphilis: A Case Report with a Brief Overview of the Diagnostic Role of Immunohistochemistry
title_full Granulomatous Secondary Syphilis: A Case Report with a Brief Overview of the Diagnostic Role of Immunohistochemistry
title_fullStr Granulomatous Secondary Syphilis: A Case Report with a Brief Overview of the Diagnostic Role of Immunohistochemistry
title_full_unstemmed Granulomatous Secondary Syphilis: A Case Report with a Brief Overview of the Diagnostic Role of Immunohistochemistry
title_short Granulomatous Secondary Syphilis: A Case Report with a Brief Overview of the Diagnostic Role of Immunohistochemistry
title_sort granulomatous secondary syphilis: a case report with a brief overview of the diagnostic role of immunohistochemistry
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10457844/
https://www.ncbi.nlm.nih.gov/pubmed/37624014
http://dx.doi.org/10.3390/pathogens12081054
work_keys_str_mv AT ambrogiofrancesca granulomatoussecondarysyphilisacasereportwithabriefoverviewofthediagnosticroleofimmunohistochemistry
AT cazzatogerardo granulomatoussecondarysyphilisacasereportwithabriefoverviewofthediagnosticroleofimmunohistochemistry
AT foticaterina granulomatoussecondarysyphilisacasereportwithabriefoverviewofthediagnosticroleofimmunohistochemistry
AT grandolfomauro granulomatoussecondarysyphilisacasereportwithabriefoverviewofthediagnosticroleofimmunohistochemistry
AT mennunigisellabiagina granulomatoussecondarysyphilisacasereportwithabriefoverviewofthediagnosticroleofimmunohistochemistry
AT venaginoantonio granulomatoussecondarysyphilisacasereportwithabriefoverviewofthediagnosticroleofimmunohistochemistry
AT cassanonicoletta granulomatoussecondarysyphilisacasereportwithabriefoverviewofthediagnosticroleofimmunohistochemistry
AT lettiniteresa granulomatoussecondarysyphilisacasereportwithabriefoverviewofthediagnosticroleofimmunohistochemistry
AT castronovicosimo granulomatoussecondarysyphilisacasereportwithabriefoverviewofthediagnosticroleofimmunohistochemistry
AT ingordovito granulomatoussecondarysyphilisacasereportwithabriefoverviewofthediagnosticroleofimmunohistochemistry
AT romitapaolo granulomatoussecondarysyphilisacasereportwithabriefoverviewofthediagnosticroleofimmunohistochemistry
AT filoticoraffaele granulomatoussecondarysyphilisacasereportwithabriefoverviewofthediagnosticroleofimmunohistochemistry