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Rice Bran Extract Suppresses High-Fat Diet-Induced Hyperlipidemia and Hepatosteatosis through Targeting AMPK and STAT3 Signaling
Rice bran, a by-product of rice milling, is abundant in bioactive molecules and is highly recognized for its health-promoting properties, particularly in improving metabolic conditions. Building on this knowledge, we aimed to optimize the extraction conditions to maximize the functional efficacy of...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10457887/ https://www.ncbi.nlm.nih.gov/pubmed/37630819 http://dx.doi.org/10.3390/nu15163630 |
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author | Son, Joe Eun Jo, Jay-Young Kim, San Park, Min Ju Lee, Yerin Park, Seong Shil Park, Shin Young Jung, Su Myung Jung, Sung Keun Kim, Ji Yeon Byun, Sanguine |
author_facet | Son, Joe Eun Jo, Jay-Young Kim, San Park, Min Ju Lee, Yerin Park, Seong Shil Park, Shin Young Jung, Su Myung Jung, Sung Keun Kim, Ji Yeon Byun, Sanguine |
author_sort | Son, Joe Eun |
collection | PubMed |
description | Rice bran, a by-product of rice milling, is abundant in bioactive molecules and is highly recognized for its health-promoting properties, particularly in improving metabolic conditions. Building on this knowledge, we aimed to optimize the extraction conditions to maximize the functional efficacy of rice bran extract (RBE) and further validate its impact on lipid metabolism. We found that the optimized RBE (ORBE) significantly suppressed high-fat diet-induced weight gain, hyperlipidemia, and hepatosteatosis in mouse models. ORBE treatment not only suppressed lipid uptake in vivo, but also reduced lipid accumulation in HepG2 cells. Importantly, we discovered that ORBE administration resulted in activation of AMPK and inhibition of STAT3, which are both crucial players in lipid metabolism in the liver. Collectively, ORBE potentially offers promise as a dietary intervention strategy against hyperlipidemia and hepatosteatosis. This study underlines the value of optimized extraction conditions in enhancing the functional efficacy of rice bran. |
format | Online Article Text |
id | pubmed-10457887 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-104578872023-08-27 Rice Bran Extract Suppresses High-Fat Diet-Induced Hyperlipidemia and Hepatosteatosis through Targeting AMPK and STAT3 Signaling Son, Joe Eun Jo, Jay-Young Kim, San Park, Min Ju Lee, Yerin Park, Seong Shil Park, Shin Young Jung, Su Myung Jung, Sung Keun Kim, Ji Yeon Byun, Sanguine Nutrients Article Rice bran, a by-product of rice milling, is abundant in bioactive molecules and is highly recognized for its health-promoting properties, particularly in improving metabolic conditions. Building on this knowledge, we aimed to optimize the extraction conditions to maximize the functional efficacy of rice bran extract (RBE) and further validate its impact on lipid metabolism. We found that the optimized RBE (ORBE) significantly suppressed high-fat diet-induced weight gain, hyperlipidemia, and hepatosteatosis in mouse models. ORBE treatment not only suppressed lipid uptake in vivo, but also reduced lipid accumulation in HepG2 cells. Importantly, we discovered that ORBE administration resulted in activation of AMPK and inhibition of STAT3, which are both crucial players in lipid metabolism in the liver. Collectively, ORBE potentially offers promise as a dietary intervention strategy against hyperlipidemia and hepatosteatosis. This study underlines the value of optimized extraction conditions in enhancing the functional efficacy of rice bran. MDPI 2023-08-18 /pmc/articles/PMC10457887/ /pubmed/37630819 http://dx.doi.org/10.3390/nu15163630 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Son, Joe Eun Jo, Jay-Young Kim, San Park, Min Ju Lee, Yerin Park, Seong Shil Park, Shin Young Jung, Su Myung Jung, Sung Keun Kim, Ji Yeon Byun, Sanguine Rice Bran Extract Suppresses High-Fat Diet-Induced Hyperlipidemia and Hepatosteatosis through Targeting AMPK and STAT3 Signaling |
title | Rice Bran Extract Suppresses High-Fat Diet-Induced Hyperlipidemia and Hepatosteatosis through Targeting AMPK and STAT3 Signaling |
title_full | Rice Bran Extract Suppresses High-Fat Diet-Induced Hyperlipidemia and Hepatosteatosis through Targeting AMPK and STAT3 Signaling |
title_fullStr | Rice Bran Extract Suppresses High-Fat Diet-Induced Hyperlipidemia and Hepatosteatosis through Targeting AMPK and STAT3 Signaling |
title_full_unstemmed | Rice Bran Extract Suppresses High-Fat Diet-Induced Hyperlipidemia and Hepatosteatosis through Targeting AMPK and STAT3 Signaling |
title_short | Rice Bran Extract Suppresses High-Fat Diet-Induced Hyperlipidemia and Hepatosteatosis through Targeting AMPK and STAT3 Signaling |
title_sort | rice bran extract suppresses high-fat diet-induced hyperlipidemia and hepatosteatosis through targeting ampk and stat3 signaling |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10457887/ https://www.ncbi.nlm.nih.gov/pubmed/37630819 http://dx.doi.org/10.3390/nu15163630 |
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