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Rice Bran Extract Suppresses High-Fat Diet-Induced Hyperlipidemia and Hepatosteatosis through Targeting AMPK and STAT3 Signaling

Rice bran, a by-product of rice milling, is abundant in bioactive molecules and is highly recognized for its health-promoting properties, particularly in improving metabolic conditions. Building on this knowledge, we aimed to optimize the extraction conditions to maximize the functional efficacy of...

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Autores principales: Son, Joe Eun, Jo, Jay-Young, Kim, San, Park, Min Ju, Lee, Yerin, Park, Seong Shil, Park, Shin Young, Jung, Su Myung, Jung, Sung Keun, Kim, Ji Yeon, Byun, Sanguine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10457887/
https://www.ncbi.nlm.nih.gov/pubmed/37630819
http://dx.doi.org/10.3390/nu15163630
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author Son, Joe Eun
Jo, Jay-Young
Kim, San
Park, Min Ju
Lee, Yerin
Park, Seong Shil
Park, Shin Young
Jung, Su Myung
Jung, Sung Keun
Kim, Ji Yeon
Byun, Sanguine
author_facet Son, Joe Eun
Jo, Jay-Young
Kim, San
Park, Min Ju
Lee, Yerin
Park, Seong Shil
Park, Shin Young
Jung, Su Myung
Jung, Sung Keun
Kim, Ji Yeon
Byun, Sanguine
author_sort Son, Joe Eun
collection PubMed
description Rice bran, a by-product of rice milling, is abundant in bioactive molecules and is highly recognized for its health-promoting properties, particularly in improving metabolic conditions. Building on this knowledge, we aimed to optimize the extraction conditions to maximize the functional efficacy of rice bran extract (RBE) and further validate its impact on lipid metabolism. We found that the optimized RBE (ORBE) significantly suppressed high-fat diet-induced weight gain, hyperlipidemia, and hepatosteatosis in mouse models. ORBE treatment not only suppressed lipid uptake in vivo, but also reduced lipid accumulation in HepG2 cells. Importantly, we discovered that ORBE administration resulted in activation of AMPK and inhibition of STAT3, which are both crucial players in lipid metabolism in the liver. Collectively, ORBE potentially offers promise as a dietary intervention strategy against hyperlipidemia and hepatosteatosis. This study underlines the value of optimized extraction conditions in enhancing the functional efficacy of rice bran.
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spelling pubmed-104578872023-08-27 Rice Bran Extract Suppresses High-Fat Diet-Induced Hyperlipidemia and Hepatosteatosis through Targeting AMPK and STAT3 Signaling Son, Joe Eun Jo, Jay-Young Kim, San Park, Min Ju Lee, Yerin Park, Seong Shil Park, Shin Young Jung, Su Myung Jung, Sung Keun Kim, Ji Yeon Byun, Sanguine Nutrients Article Rice bran, a by-product of rice milling, is abundant in bioactive molecules and is highly recognized for its health-promoting properties, particularly in improving metabolic conditions. Building on this knowledge, we aimed to optimize the extraction conditions to maximize the functional efficacy of rice bran extract (RBE) and further validate its impact on lipid metabolism. We found that the optimized RBE (ORBE) significantly suppressed high-fat diet-induced weight gain, hyperlipidemia, and hepatosteatosis in mouse models. ORBE treatment not only suppressed lipid uptake in vivo, but also reduced lipid accumulation in HepG2 cells. Importantly, we discovered that ORBE administration resulted in activation of AMPK and inhibition of STAT3, which are both crucial players in lipid metabolism in the liver. Collectively, ORBE potentially offers promise as a dietary intervention strategy against hyperlipidemia and hepatosteatosis. This study underlines the value of optimized extraction conditions in enhancing the functional efficacy of rice bran. MDPI 2023-08-18 /pmc/articles/PMC10457887/ /pubmed/37630819 http://dx.doi.org/10.3390/nu15163630 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Son, Joe Eun
Jo, Jay-Young
Kim, San
Park, Min Ju
Lee, Yerin
Park, Seong Shil
Park, Shin Young
Jung, Su Myung
Jung, Sung Keun
Kim, Ji Yeon
Byun, Sanguine
Rice Bran Extract Suppresses High-Fat Diet-Induced Hyperlipidemia and Hepatosteatosis through Targeting AMPK and STAT3 Signaling
title Rice Bran Extract Suppresses High-Fat Diet-Induced Hyperlipidemia and Hepatosteatosis through Targeting AMPK and STAT3 Signaling
title_full Rice Bran Extract Suppresses High-Fat Diet-Induced Hyperlipidemia and Hepatosteatosis through Targeting AMPK and STAT3 Signaling
title_fullStr Rice Bran Extract Suppresses High-Fat Diet-Induced Hyperlipidemia and Hepatosteatosis through Targeting AMPK and STAT3 Signaling
title_full_unstemmed Rice Bran Extract Suppresses High-Fat Diet-Induced Hyperlipidemia and Hepatosteatosis through Targeting AMPK and STAT3 Signaling
title_short Rice Bran Extract Suppresses High-Fat Diet-Induced Hyperlipidemia and Hepatosteatosis through Targeting AMPK and STAT3 Signaling
title_sort rice bran extract suppresses high-fat diet-induced hyperlipidemia and hepatosteatosis through targeting ampk and stat3 signaling
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10457887/
https://www.ncbi.nlm.nih.gov/pubmed/37630819
http://dx.doi.org/10.3390/nu15163630
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