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Biochemical, Antioxidant Properties and Antimicrobial Activity of Steno-Endemic Origanum onites
Origanum onites (Lamiaceae) is an Eastern Mediterranean plant that is widely used in Turkish traditional medicine. This study aimed to investigate the biochemical composition, antimicrobial activity, and antioxidant potential of O. onites. In this study, the biochemical composition of the O. onites...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10457892/ https://www.ncbi.nlm.nih.gov/pubmed/37630547 http://dx.doi.org/10.3390/microorganisms11081987 |
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author | Canli, Kerem Bozyel, Mustafa Eray Turu, Dilay Benek, Atakan Simsek, Ozcan Altuner, Ergin Murat |
author_facet | Canli, Kerem Bozyel, Mustafa Eray Turu, Dilay Benek, Atakan Simsek, Ozcan Altuner, Ergin Murat |
author_sort | Canli, Kerem |
collection | PubMed |
description | Origanum onites (Lamiaceae) is an Eastern Mediterranean plant that is widely used in Turkish traditional medicine. This study aimed to investigate the biochemical composition, antimicrobial activity, and antioxidant potential of O. onites. In this study, the biochemical composition of the O. onites ethanol extract (OOEt) was analyzed using GC-MS. The antimicrobial activity was investigated using a disk diffusion test and determining minimum inhibitory concentrations (MIC) against 30 microorganism strains, including 28 bacteria (some multidrug-resistant) and 2 fungi. Additionally, the antioxidant activity was evaluated using the DPPH method. The main component identified was carvacrol. OOEt demonstrated antimicrobial activity against a wide range of tested microorganism strains. OOEt displayed the highest activity against E. faecium (a Gram-positive bacterium) at 100 µL with a 52 mm inhibition zone. Additionally, P. aeruginosa DSMZ 50071 and P. fluorescens P1, which are Gram-negative bacteria, were the most sensitive strains with a 24 mm inhibition zone in 100 µL of OOEt. The data obtained from A. baumannii (a multidrug-resistant strain) is particularly striking, as higher activity was observed compared to all positive controls. All tested fungal strains showed more effective results than positive controls. The antioxidant activity of OOEt was found to be stronger than that of the positive control, ascorbic acid. This study determined that O. onites has significant antimicrobial and antioxidant potential. |
format | Online Article Text |
id | pubmed-10457892 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-104578922023-08-27 Biochemical, Antioxidant Properties and Antimicrobial Activity of Steno-Endemic Origanum onites Canli, Kerem Bozyel, Mustafa Eray Turu, Dilay Benek, Atakan Simsek, Ozcan Altuner, Ergin Murat Microorganisms Article Origanum onites (Lamiaceae) is an Eastern Mediterranean plant that is widely used in Turkish traditional medicine. This study aimed to investigate the biochemical composition, antimicrobial activity, and antioxidant potential of O. onites. In this study, the biochemical composition of the O. onites ethanol extract (OOEt) was analyzed using GC-MS. The antimicrobial activity was investigated using a disk diffusion test and determining minimum inhibitory concentrations (MIC) against 30 microorganism strains, including 28 bacteria (some multidrug-resistant) and 2 fungi. Additionally, the antioxidant activity was evaluated using the DPPH method. The main component identified was carvacrol. OOEt demonstrated antimicrobial activity against a wide range of tested microorganism strains. OOEt displayed the highest activity against E. faecium (a Gram-positive bacterium) at 100 µL with a 52 mm inhibition zone. Additionally, P. aeruginosa DSMZ 50071 and P. fluorescens P1, which are Gram-negative bacteria, were the most sensitive strains with a 24 mm inhibition zone in 100 µL of OOEt. The data obtained from A. baumannii (a multidrug-resistant strain) is particularly striking, as higher activity was observed compared to all positive controls. All tested fungal strains showed more effective results than positive controls. The antioxidant activity of OOEt was found to be stronger than that of the positive control, ascorbic acid. This study determined that O. onites has significant antimicrobial and antioxidant potential. MDPI 2023-08-02 /pmc/articles/PMC10457892/ /pubmed/37630547 http://dx.doi.org/10.3390/microorganisms11081987 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Canli, Kerem Bozyel, Mustafa Eray Turu, Dilay Benek, Atakan Simsek, Ozcan Altuner, Ergin Murat Biochemical, Antioxidant Properties and Antimicrobial Activity of Steno-Endemic Origanum onites |
title | Biochemical, Antioxidant Properties and Antimicrobial Activity of Steno-Endemic Origanum onites |
title_full | Biochemical, Antioxidant Properties and Antimicrobial Activity of Steno-Endemic Origanum onites |
title_fullStr | Biochemical, Antioxidant Properties and Antimicrobial Activity of Steno-Endemic Origanum onites |
title_full_unstemmed | Biochemical, Antioxidant Properties and Antimicrobial Activity of Steno-Endemic Origanum onites |
title_short | Biochemical, Antioxidant Properties and Antimicrobial Activity of Steno-Endemic Origanum onites |
title_sort | biochemical, antioxidant properties and antimicrobial activity of steno-endemic origanum onites |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10457892/ https://www.ncbi.nlm.nih.gov/pubmed/37630547 http://dx.doi.org/10.3390/microorganisms11081987 |
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