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High Levels of Anti-SARS-CoV-2 Receptor-Binding Domain (RBD) Antibodies One Year Post Booster Vaccinations among Hospital Workers in Indonesia: Was the Second Booster Needed?
In August 2022, Indonesia prioritized healthcare workers to receive the second booster dose. We conducted a sequential serosurvey to understand the dynamics of the antibody titers. The first serosurvey, which was conducted in June 2021, 1–6 months after Sinovac vaccination, showed a median antibody...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10457959/ https://www.ncbi.nlm.nih.gov/pubmed/37631868 http://dx.doi.org/10.3390/vaccines11081300 |
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author | Muslimah, Amila Hanifan Tiara, Marita Restie Djauhari, Hofiya Dewantara, Muhammad Hafizh Susandi, Evan Indrati, Agnes Rengga Alisjahbana, Bachti Soeroto, Arto Yuwono Wisaksana, Rudi |
author_facet | Muslimah, Amila Hanifan Tiara, Marita Restie Djauhari, Hofiya Dewantara, Muhammad Hafizh Susandi, Evan Indrati, Agnes Rengga Alisjahbana, Bachti Soeroto, Arto Yuwono Wisaksana, Rudi |
author_sort | Muslimah, Amila Hanifan |
collection | PubMed |
description | In August 2022, Indonesia prioritized healthcare workers to receive the second booster dose. We conducted a sequential serosurvey to understand the dynamics of the antibody titers. The first serosurvey, which was conducted in June 2021, 1–6 months after Sinovac vaccination, showed a median antibody level of 41.4 BAU/mL (interquartile range (IQR): 10–629.4 BAU/mL). The second serosurvey was conducted one month (August 2021) after the first Moderna booster vaccine and showed a median level of 4000 BAU/mL (IQR: 3081–4000 BAU/mL). The last serosurvey was conducted a year (August 2022) after the booster and showed a median level of 4000 BAU/mL (IQR: 4000–4000 BAU/mL). In this last survey, only 39 (11.9%) of healthcare workers had antibody levels below the maximum level of 4000 BAU/mL. Thus, one year after the first booster dose, we did not observe the waning of antibody levels. The average increase was perhaps because of natural infection. Based on these considerations, we believe that a second booster dose was not necessary for this category of subjects at that time. Because vaccine supply is often limited, priority could be given to the general population or other high-risk patient groups with low antibody titers based on serological tests. |
format | Online Article Text |
id | pubmed-10457959 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-104579592023-08-27 High Levels of Anti-SARS-CoV-2 Receptor-Binding Domain (RBD) Antibodies One Year Post Booster Vaccinations among Hospital Workers in Indonesia: Was the Second Booster Needed? Muslimah, Amila Hanifan Tiara, Marita Restie Djauhari, Hofiya Dewantara, Muhammad Hafizh Susandi, Evan Indrati, Agnes Rengga Alisjahbana, Bachti Soeroto, Arto Yuwono Wisaksana, Rudi Vaccines (Basel) Brief Report In August 2022, Indonesia prioritized healthcare workers to receive the second booster dose. We conducted a sequential serosurvey to understand the dynamics of the antibody titers. The first serosurvey, which was conducted in June 2021, 1–6 months after Sinovac vaccination, showed a median antibody level of 41.4 BAU/mL (interquartile range (IQR): 10–629.4 BAU/mL). The second serosurvey was conducted one month (August 2021) after the first Moderna booster vaccine and showed a median level of 4000 BAU/mL (IQR: 3081–4000 BAU/mL). The last serosurvey was conducted a year (August 2022) after the booster and showed a median level of 4000 BAU/mL (IQR: 4000–4000 BAU/mL). In this last survey, only 39 (11.9%) of healthcare workers had antibody levels below the maximum level of 4000 BAU/mL. Thus, one year after the first booster dose, we did not observe the waning of antibody levels. The average increase was perhaps because of natural infection. Based on these considerations, we believe that a second booster dose was not necessary for this category of subjects at that time. Because vaccine supply is often limited, priority could be given to the general population or other high-risk patient groups with low antibody titers based on serological tests. MDPI 2023-07-30 /pmc/articles/PMC10457959/ /pubmed/37631868 http://dx.doi.org/10.3390/vaccines11081300 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Brief Report Muslimah, Amila Hanifan Tiara, Marita Restie Djauhari, Hofiya Dewantara, Muhammad Hafizh Susandi, Evan Indrati, Agnes Rengga Alisjahbana, Bachti Soeroto, Arto Yuwono Wisaksana, Rudi High Levels of Anti-SARS-CoV-2 Receptor-Binding Domain (RBD) Antibodies One Year Post Booster Vaccinations among Hospital Workers in Indonesia: Was the Second Booster Needed? |
title | High Levels of Anti-SARS-CoV-2 Receptor-Binding Domain (RBD) Antibodies One Year Post Booster Vaccinations among Hospital Workers in Indonesia: Was the Second Booster Needed? |
title_full | High Levels of Anti-SARS-CoV-2 Receptor-Binding Domain (RBD) Antibodies One Year Post Booster Vaccinations among Hospital Workers in Indonesia: Was the Second Booster Needed? |
title_fullStr | High Levels of Anti-SARS-CoV-2 Receptor-Binding Domain (RBD) Antibodies One Year Post Booster Vaccinations among Hospital Workers in Indonesia: Was the Second Booster Needed? |
title_full_unstemmed | High Levels of Anti-SARS-CoV-2 Receptor-Binding Domain (RBD) Antibodies One Year Post Booster Vaccinations among Hospital Workers in Indonesia: Was the Second Booster Needed? |
title_short | High Levels of Anti-SARS-CoV-2 Receptor-Binding Domain (RBD) Antibodies One Year Post Booster Vaccinations among Hospital Workers in Indonesia: Was the Second Booster Needed? |
title_sort | high levels of anti-sars-cov-2 receptor-binding domain (rbd) antibodies one year post booster vaccinations among hospital workers in indonesia: was the second booster needed? |
topic | Brief Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10457959/ https://www.ncbi.nlm.nih.gov/pubmed/37631868 http://dx.doi.org/10.3390/vaccines11081300 |
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