Cargando…

High Levels of Anti-SARS-CoV-2 Receptor-Binding Domain (RBD) Antibodies One Year Post Booster Vaccinations among Hospital Workers in Indonesia: Was the Second Booster Needed?

In August 2022, Indonesia prioritized healthcare workers to receive the second booster dose. We conducted a sequential serosurvey to understand the dynamics of the antibody titers. The first serosurvey, which was conducted in June 2021, 1–6 months after Sinovac vaccination, showed a median antibody...

Descripción completa

Detalles Bibliográficos
Autores principales: Muslimah, Amila Hanifan, Tiara, Marita Restie, Djauhari, Hofiya, Dewantara, Muhammad Hafizh, Susandi, Evan, Indrati, Agnes Rengga, Alisjahbana, Bachti, Soeroto, Arto Yuwono, Wisaksana, Rudi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10457959/
https://www.ncbi.nlm.nih.gov/pubmed/37631868
http://dx.doi.org/10.3390/vaccines11081300
_version_ 1785097049895600128
author Muslimah, Amila Hanifan
Tiara, Marita Restie
Djauhari, Hofiya
Dewantara, Muhammad Hafizh
Susandi, Evan
Indrati, Agnes Rengga
Alisjahbana, Bachti
Soeroto, Arto Yuwono
Wisaksana, Rudi
author_facet Muslimah, Amila Hanifan
Tiara, Marita Restie
Djauhari, Hofiya
Dewantara, Muhammad Hafizh
Susandi, Evan
Indrati, Agnes Rengga
Alisjahbana, Bachti
Soeroto, Arto Yuwono
Wisaksana, Rudi
author_sort Muslimah, Amila Hanifan
collection PubMed
description In August 2022, Indonesia prioritized healthcare workers to receive the second booster dose. We conducted a sequential serosurvey to understand the dynamics of the antibody titers. The first serosurvey, which was conducted in June 2021, 1–6 months after Sinovac vaccination, showed a median antibody level of 41.4 BAU/mL (interquartile range (IQR): 10–629.4 BAU/mL). The second serosurvey was conducted one month (August 2021) after the first Moderna booster vaccine and showed a median level of 4000 BAU/mL (IQR: 3081–4000 BAU/mL). The last serosurvey was conducted a year (August 2022) after the booster and showed a median level of 4000 BAU/mL (IQR: 4000–4000 BAU/mL). In this last survey, only 39 (11.9%) of healthcare workers had antibody levels below the maximum level of 4000 BAU/mL. Thus, one year after the first booster dose, we did not observe the waning of antibody levels. The average increase was perhaps because of natural infection. Based on these considerations, we believe that a second booster dose was not necessary for this category of subjects at that time. Because vaccine supply is often limited, priority could be given to the general population or other high-risk patient groups with low antibody titers based on serological tests.
format Online
Article
Text
id pubmed-10457959
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-104579592023-08-27 High Levels of Anti-SARS-CoV-2 Receptor-Binding Domain (RBD) Antibodies One Year Post Booster Vaccinations among Hospital Workers in Indonesia: Was the Second Booster Needed? Muslimah, Amila Hanifan Tiara, Marita Restie Djauhari, Hofiya Dewantara, Muhammad Hafizh Susandi, Evan Indrati, Agnes Rengga Alisjahbana, Bachti Soeroto, Arto Yuwono Wisaksana, Rudi Vaccines (Basel) Brief Report In August 2022, Indonesia prioritized healthcare workers to receive the second booster dose. We conducted a sequential serosurvey to understand the dynamics of the antibody titers. The first serosurvey, which was conducted in June 2021, 1–6 months after Sinovac vaccination, showed a median antibody level of 41.4 BAU/mL (interquartile range (IQR): 10–629.4 BAU/mL). The second serosurvey was conducted one month (August 2021) after the first Moderna booster vaccine and showed a median level of 4000 BAU/mL (IQR: 3081–4000 BAU/mL). The last serosurvey was conducted a year (August 2022) after the booster and showed a median level of 4000 BAU/mL (IQR: 4000–4000 BAU/mL). In this last survey, only 39 (11.9%) of healthcare workers had antibody levels below the maximum level of 4000 BAU/mL. Thus, one year after the first booster dose, we did not observe the waning of antibody levels. The average increase was perhaps because of natural infection. Based on these considerations, we believe that a second booster dose was not necessary for this category of subjects at that time. Because vaccine supply is often limited, priority could be given to the general population or other high-risk patient groups with low antibody titers based on serological tests. MDPI 2023-07-30 /pmc/articles/PMC10457959/ /pubmed/37631868 http://dx.doi.org/10.3390/vaccines11081300 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Brief Report
Muslimah, Amila Hanifan
Tiara, Marita Restie
Djauhari, Hofiya
Dewantara, Muhammad Hafizh
Susandi, Evan
Indrati, Agnes Rengga
Alisjahbana, Bachti
Soeroto, Arto Yuwono
Wisaksana, Rudi
High Levels of Anti-SARS-CoV-2 Receptor-Binding Domain (RBD) Antibodies One Year Post Booster Vaccinations among Hospital Workers in Indonesia: Was the Second Booster Needed?
title High Levels of Anti-SARS-CoV-2 Receptor-Binding Domain (RBD) Antibodies One Year Post Booster Vaccinations among Hospital Workers in Indonesia: Was the Second Booster Needed?
title_full High Levels of Anti-SARS-CoV-2 Receptor-Binding Domain (RBD) Antibodies One Year Post Booster Vaccinations among Hospital Workers in Indonesia: Was the Second Booster Needed?
title_fullStr High Levels of Anti-SARS-CoV-2 Receptor-Binding Domain (RBD) Antibodies One Year Post Booster Vaccinations among Hospital Workers in Indonesia: Was the Second Booster Needed?
title_full_unstemmed High Levels of Anti-SARS-CoV-2 Receptor-Binding Domain (RBD) Antibodies One Year Post Booster Vaccinations among Hospital Workers in Indonesia: Was the Second Booster Needed?
title_short High Levels of Anti-SARS-CoV-2 Receptor-Binding Domain (RBD) Antibodies One Year Post Booster Vaccinations among Hospital Workers in Indonesia: Was the Second Booster Needed?
title_sort high levels of anti-sars-cov-2 receptor-binding domain (rbd) antibodies one year post booster vaccinations among hospital workers in indonesia: was the second booster needed?
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10457959/
https://www.ncbi.nlm.nih.gov/pubmed/37631868
http://dx.doi.org/10.3390/vaccines11081300
work_keys_str_mv AT muslimahamilahanifan highlevelsofantisarscov2receptorbindingdomainrbdantibodiesoneyearpostboostervaccinationsamonghospitalworkersinindonesiawasthesecondboosterneeded
AT tiaramaritarestie highlevelsofantisarscov2receptorbindingdomainrbdantibodiesoneyearpostboostervaccinationsamonghospitalworkersinindonesiawasthesecondboosterneeded
AT djauharihofiya highlevelsofantisarscov2receptorbindingdomainrbdantibodiesoneyearpostboostervaccinationsamonghospitalworkersinindonesiawasthesecondboosterneeded
AT dewantaramuhammadhafizh highlevelsofantisarscov2receptorbindingdomainrbdantibodiesoneyearpostboostervaccinationsamonghospitalworkersinindonesiawasthesecondboosterneeded
AT susandievan highlevelsofantisarscov2receptorbindingdomainrbdantibodiesoneyearpostboostervaccinationsamonghospitalworkersinindonesiawasthesecondboosterneeded
AT indratiagnesrengga highlevelsofantisarscov2receptorbindingdomainrbdantibodiesoneyearpostboostervaccinationsamonghospitalworkersinindonesiawasthesecondboosterneeded
AT alisjahbanabachti highlevelsofantisarscov2receptorbindingdomainrbdantibodiesoneyearpostboostervaccinationsamonghospitalworkersinindonesiawasthesecondboosterneeded
AT soerotoartoyuwono highlevelsofantisarscov2receptorbindingdomainrbdantibodiesoneyearpostboostervaccinationsamonghospitalworkersinindonesiawasthesecondboosterneeded
AT wisaksanarudi highlevelsofantisarscov2receptorbindingdomainrbdantibodiesoneyearpostboostervaccinationsamonghospitalworkersinindonesiawasthesecondboosterneeded