Effect of Nitrogen Arc Discharge Plasma Treatment on Physicochemical Properties and Biocompatibility of PLA-Based Scaffolds

The effect of low-temperature arc discharge plasma treatment in a nitrogen atmosphere on the modification of the physicochemical properties of PLA-based scaffolds was studied. In addition, the cellular-mediated immune response when macrophages of three donors interact with the modified surfaces of P...

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Autores principales: Laput, Olesya A., Vasenina, Irina V., Korzhova, Alena G., Bryuzgina, Anastasia A., Khomutova, Ulyana V., Tuyakova, Sitora G., Akhmadeev, Yuriy H., Shugurov, Vladimir V., Bolbasov, Evgeny N., Tverdokhlebov, Sergei I., Chernyavskii, Aleksandr V., Kurzina, Irina A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10458013/
https://www.ncbi.nlm.nih.gov/pubmed/37631437
http://dx.doi.org/10.3390/polym15163381
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author Laput, Olesya A.
Vasenina, Irina V.
Korzhova, Alena G.
Bryuzgina, Anastasia A.
Khomutova, Ulyana V.
Tuyakova, Sitora G.
Akhmadeev, Yuriy H.
Shugurov, Vladimir V.
Bolbasov, Evgeny N.
Tverdokhlebov, Sergei I.
Chernyavskii, Aleksandr V.
Kurzina, Irina A.
author_facet Laput, Olesya A.
Vasenina, Irina V.
Korzhova, Alena G.
Bryuzgina, Anastasia A.
Khomutova, Ulyana V.
Tuyakova, Sitora G.
Akhmadeev, Yuriy H.
Shugurov, Vladimir V.
Bolbasov, Evgeny N.
Tverdokhlebov, Sergei I.
Chernyavskii, Aleksandr V.
Kurzina, Irina A.
author_sort Laput, Olesya A.
collection PubMed
description The effect of low-temperature arc discharge plasma treatment in a nitrogen atmosphere on the modification of the physicochemical properties of PLA-based scaffolds was studied. In addition, the cellular-mediated immune response when macrophages of three donors interact with the modified surfaces of PLA-based scaffolds was investigated. PLA surface carbonization, accompanied by a carbon atomic concentration increase, was revealed to occur because of plasma treatment. Nitrogen plasma significantly influenced the PLA wettability characteristics, namely, the hydrophilicity and lipophilicity were improved, as well as the surface energy being raised. The viability of cells in the presence of the plasma-modified PLA scaffolds was evaluated to be higher than that of the initial cells.
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spelling pubmed-104580132023-08-27 Effect of Nitrogen Arc Discharge Plasma Treatment on Physicochemical Properties and Biocompatibility of PLA-Based Scaffolds Laput, Olesya A. Vasenina, Irina V. Korzhova, Alena G. Bryuzgina, Anastasia A. Khomutova, Ulyana V. Tuyakova, Sitora G. Akhmadeev, Yuriy H. Shugurov, Vladimir V. Bolbasov, Evgeny N. Tverdokhlebov, Sergei I. Chernyavskii, Aleksandr V. Kurzina, Irina A. Polymers (Basel) Article The effect of low-temperature arc discharge plasma treatment in a nitrogen atmosphere on the modification of the physicochemical properties of PLA-based scaffolds was studied. In addition, the cellular-mediated immune response when macrophages of three donors interact with the modified surfaces of PLA-based scaffolds was investigated. PLA surface carbonization, accompanied by a carbon atomic concentration increase, was revealed to occur because of plasma treatment. Nitrogen plasma significantly influenced the PLA wettability characteristics, namely, the hydrophilicity and lipophilicity were improved, as well as the surface energy being raised. The viability of cells in the presence of the plasma-modified PLA scaffolds was evaluated to be higher than that of the initial cells. MDPI 2023-08-11 /pmc/articles/PMC10458013/ /pubmed/37631437 http://dx.doi.org/10.3390/polym15163381 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Laput, Olesya A.
Vasenina, Irina V.
Korzhova, Alena G.
Bryuzgina, Anastasia A.
Khomutova, Ulyana V.
Tuyakova, Sitora G.
Akhmadeev, Yuriy H.
Shugurov, Vladimir V.
Bolbasov, Evgeny N.
Tverdokhlebov, Sergei I.
Chernyavskii, Aleksandr V.
Kurzina, Irina A.
Effect of Nitrogen Arc Discharge Plasma Treatment on Physicochemical Properties and Biocompatibility of PLA-Based Scaffolds
title Effect of Nitrogen Arc Discharge Plasma Treatment on Physicochemical Properties and Biocompatibility of PLA-Based Scaffolds
title_full Effect of Nitrogen Arc Discharge Plasma Treatment on Physicochemical Properties and Biocompatibility of PLA-Based Scaffolds
title_fullStr Effect of Nitrogen Arc Discharge Plasma Treatment on Physicochemical Properties and Biocompatibility of PLA-Based Scaffolds
title_full_unstemmed Effect of Nitrogen Arc Discharge Plasma Treatment on Physicochemical Properties and Biocompatibility of PLA-Based Scaffolds
title_short Effect of Nitrogen Arc Discharge Plasma Treatment on Physicochemical Properties and Biocompatibility of PLA-Based Scaffolds
title_sort effect of nitrogen arc discharge plasma treatment on physicochemical properties and biocompatibility of pla-based scaffolds
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10458013/
https://www.ncbi.nlm.nih.gov/pubmed/37631437
http://dx.doi.org/10.3390/polym15163381
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