Cargando…

Living-Neuron-Based Autogenerator

We present a novel closed-loop system designed to integrate biological and artificial neurons of the oscillatory type into a unified circuit. The system comprises an electronic circuit based on the FitzHugh-Nagumo model, which provides stimulation to living neurons in acute hippocampal mouse brain s...

Descripción completa

Detalles Bibliográficos
Autores principales: Gerasimova, Svetlana A., Beltyukova, Anna, Fedulina, Anastasia, Matveeva, Maria, Lebedeva, Albina V., Pisarchik, Alexander N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10458024/
https://www.ncbi.nlm.nih.gov/pubmed/37631552
http://dx.doi.org/10.3390/s23167016
Descripción
Sumario:We present a novel closed-loop system designed to integrate biological and artificial neurons of the oscillatory type into a unified circuit. The system comprises an electronic circuit based on the FitzHugh-Nagumo model, which provides stimulation to living neurons in acute hippocampal mouse brain slices. The local field potentials generated by the living neurons trigger a transition in the FitzHugh–Nagumo circuit from an excitable state to an oscillatory mode, and in turn, the spikes produced by the electronic circuit synchronize with the living-neuron spikes. The key advantage of this hybrid electrobiological autogenerator lies in its capability to control biological neuron signals, which holds significant promise for diverse neuromorphic applications.