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Living-Neuron-Based Autogenerator

We present a novel closed-loop system designed to integrate biological and artificial neurons of the oscillatory type into a unified circuit. The system comprises an electronic circuit based on the FitzHugh-Nagumo model, which provides stimulation to living neurons in acute hippocampal mouse brain s...

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Detalles Bibliográficos
Autores principales: Gerasimova, Svetlana A., Beltyukova, Anna, Fedulina, Anastasia, Matveeva, Maria, Lebedeva, Albina V., Pisarchik, Alexander N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10458024/
https://www.ncbi.nlm.nih.gov/pubmed/37631552
http://dx.doi.org/10.3390/s23167016
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author Gerasimova, Svetlana A.
Beltyukova, Anna
Fedulina, Anastasia
Matveeva, Maria
Lebedeva, Albina V.
Pisarchik, Alexander N.
author_facet Gerasimova, Svetlana A.
Beltyukova, Anna
Fedulina, Anastasia
Matveeva, Maria
Lebedeva, Albina V.
Pisarchik, Alexander N.
author_sort Gerasimova, Svetlana A.
collection PubMed
description We present a novel closed-loop system designed to integrate biological and artificial neurons of the oscillatory type into a unified circuit. The system comprises an electronic circuit based on the FitzHugh-Nagumo model, which provides stimulation to living neurons in acute hippocampal mouse brain slices. The local field potentials generated by the living neurons trigger a transition in the FitzHugh–Nagumo circuit from an excitable state to an oscillatory mode, and in turn, the spikes produced by the electronic circuit synchronize with the living-neuron spikes. The key advantage of this hybrid electrobiological autogenerator lies in its capability to control biological neuron signals, which holds significant promise for diverse neuromorphic applications.
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spelling pubmed-104580242023-08-27 Living-Neuron-Based Autogenerator Gerasimova, Svetlana A. Beltyukova, Anna Fedulina, Anastasia Matveeva, Maria Lebedeva, Albina V. Pisarchik, Alexander N. Sensors (Basel) Article We present a novel closed-loop system designed to integrate biological and artificial neurons of the oscillatory type into a unified circuit. The system comprises an electronic circuit based on the FitzHugh-Nagumo model, which provides stimulation to living neurons in acute hippocampal mouse brain slices. The local field potentials generated by the living neurons trigger a transition in the FitzHugh–Nagumo circuit from an excitable state to an oscillatory mode, and in turn, the spikes produced by the electronic circuit synchronize with the living-neuron spikes. The key advantage of this hybrid electrobiological autogenerator lies in its capability to control biological neuron signals, which holds significant promise for diverse neuromorphic applications. MDPI 2023-08-08 /pmc/articles/PMC10458024/ /pubmed/37631552 http://dx.doi.org/10.3390/s23167016 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Gerasimova, Svetlana A.
Beltyukova, Anna
Fedulina, Anastasia
Matveeva, Maria
Lebedeva, Albina V.
Pisarchik, Alexander N.
Living-Neuron-Based Autogenerator
title Living-Neuron-Based Autogenerator
title_full Living-Neuron-Based Autogenerator
title_fullStr Living-Neuron-Based Autogenerator
title_full_unstemmed Living-Neuron-Based Autogenerator
title_short Living-Neuron-Based Autogenerator
title_sort living-neuron-based autogenerator
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10458024/
https://www.ncbi.nlm.nih.gov/pubmed/37631552
http://dx.doi.org/10.3390/s23167016
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